Granzymes: a family of lymphocyte granule serine proteases

por Trapani, Joseph A
Publicado 2001

Perforinopathy: A Spectrum of Human Immune Disease Caused by Defective Perforin Delivery or Function

por Voskoboinik, Ilia, Trapani, Joseph A.
Publicado 2013

A novel role for granzymes in anti-tumor immunity

por Hoves, Sabine, Sutton, Vivien R., Trapani, Joseph A.
Publicado 2012

Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy

por Nüssing, Simone, Trapani, Joseph A., Parish, Ian A.
Publicado 2020

Challenges of PD-L1 testing in non-small cell lung cancer and beyond

por Wang, Minyu, Wang, Sen, Trapani, Joseph A., Neeson, Paul J.
Publicado 2020

Therapeutic strategies to remodel immunologically cold tumors

por Wang, Minyu, Wang, Sen, Desai, Jayesh, Trapani, Joseph A, Neeson, Paul J
Publicado 2020

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

por Street, Shayna E.A., Trapani, Joseph A., MacGregor, Duncan, Smyth, Mark J.
Publicado 2002

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization

por Shi, Lianfa, Mai, Sabine, Israels, Sara, Browne, Kylie, Trapani, Joseph A., Greenberg, Arnold H.
Publicado 1997

Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer

por Brasacchio, Daniella, Busuttil, Rita A., Noori, Tahereh, Johnstone, Ricky W., Boussioutas, Alex, Trapani, Joseph A.
Publicado 2018

Lipid specificity of the immune effector perforin

por Hodel, Adrian W., Rudd-Schmidt, Jesse A., Trapani, Joseph A., Voskoboinik, Ilia, Hoogenboom, Bart W.
Publicado 2020

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

por D’Angelo, Michael E, Dunstone, Michelle A, Whisstock, James C, Trapani, Joseph A, Bird, Phillip I
Publicado 2012

B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis

por Hagn, Magdalena, Panikkar, Archana, Smith, Corey, Balfour Jr, Henry H, Khanna, Rajiv, Voskoboinik, Ilia, Trapani, Joseph A
Publicado 2015

The pore conformation of lymphocyte perforin

por Ivanova, Marina E., Lukoyanova, Natalya, Malhotra, Sony, Topf, Maya, Trapani, Joseph A., Voskoboinik, Ilia, Saibil, Helen R.
Publicado 2022

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma

por Smyth, Mark J., Thia, Kevin Y.T., Street, Shayna E.A., MacGregor, Duncan, Godfrey, Dale I., Trapani, Joseph A.
Publicado 2000

Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity

por Spicer, Julie A., Huttunen, Kristiina M., Jose, Jiney, Dimitrov, Ivo, Akhlaghi, Hedieh, Sutton, Vivien R., Voskoboinik, Ilia, Trapani, Joseph
Publicado 2022

Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

por Waterhouse, Nigel J., Sutton, Vivien R., Sedelies, Karin A, Ciccone, Annette, Jenkins, Misty, Turner, Stephen J., Bird, Phillip I., Trapani, Joseph A.
Publicado 2006

Residual active granzyme B in cathepsin C–null lymphocytes is sufficient for perforin-dependent target cell apoptosis

por Sutton, Vivien R., Waterhouse, Nigel J., Browne, Kylie A., Sedelies, Karin, Ciccone, Annette, Anthony, Desiree, Koskinen, Aulikki, Mullbacher, Arno, Trapani, Joseph A.
Publicado 2007

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

por Sutton, Vivien R., Davis, Joanne E., Cancilla, Michael, Johnstone, Ricky W., Ruefli, Astrid A., Sedelies, Karin, Browne, Kylie A., Trapani, Joseph A.
Publicado 2000

Granzyme B Is Dispensable in the Development of Diabetes in Non-Obese Diabetic Mice

por Mollah, Zia U., Graham, Kate L., Krishnamurthy, Balasubramanian, Trivedi, Prerak, Brodnicki, Thomas C., Trapani, Joseph A., Kay, Thomas W., Thomas, Helen E.
Publicado 2012

Enhancing the Potential of Immunotherapy in Paediatric Sarcomas: Breaking the Immunosuppressive Barrier with Receptor Tyrosine Kinase Inhibitors

por Fleuren, Emmy D. G., Terry, Rachael L., Meyran, Deborah, Omer, Natacha, Trapani, Joseph A., Haber, Michelle, Neeson, Paul J., Ekert, Paul G.
Publicado 2021