Engineering Strategies to Overcome the Stability–Function Trade-Off in Proteins

por Teufl, Magdalena, Zajc, Charlotte U., Traxlmayr, Michael W.
Publicado 2022

Engineered IgG1‐Fc – one fragment to bind them all

por Lobner, Elisabeth, Traxlmayr, Michael W., Obinger, Christian, Hasenhindl, Christoph
Publicado 2016

Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast

por Traxlmayr, Michael W., Faissner, Maximilian, Stadlmayr, Gerhard, Hasenhindl, Christoph, Antes, Bernhard, Rüker, Florian, Obinger, Christian
Publicado 2012

Construction of pH-sensitive Her2-binding IgG1-Fc by directed evolution

por Traxlmayr, Michael W, Lobner, Elisabeth, Hasenhindl, Christoph, Stadlmayr, Gerhard, Oostenbrink, Chris, Rüker, Florian, Obinger, Christian
Publicado 2014

Driving CARs with alternative navigation tools – the potential of engineered binding scaffolds

por Zajc, Charlotte U., Salzer, Benjamin, Taft, Joseph M., Reddy, Sai T., Lehner, Manfred, Traxlmayr, Michael W.
Publicado 2020

Stability assessment on a library scale: a rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc

por Hasenhindl, Christoph, Traxlmayr, Michael W., Wozniak-Knopp, Gordana, Jones, Phil C., Stadlmayr, Gerhard, Rüker, Florian, Obinger, Christian
Publicado 2013

Identification of Activating Mutations in the Transmembrane and Extracellular Domains of EGFR

por Wagner, Anja, Galicia-Andrés, Edgar, Teufl, Magdalena, Gold, Lukas, Obinger, Christian, Sykacek, Peter, Oostenbrink, Chris, Traxlmayr, Michael W.
Publicado 2022

Creating stable stem regions for loop elongation in Fcabs — Insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations

por Hasenhindl, Christoph, Lai, Balder, Delgado, Javier, Traxlmayr, Michael W., Stadlmayr, Gerhard, Rüker, Florian, Serrano, Luis, Oostenbrink, Chris, Obinger, Christian
Publicado 2014

Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 Å crystal structure of the complex

por Lobner, Elisabeth, Humm, Anne-Sophie, Mlynek, Georg, Kubinger, Konstantin, Kitzmüller, Michael, Traxlmayr, Michael W., Djinović-Carugo, Kristina, Obinger, Christian
Publicado 2017

Construction of a Stability Landscape of the CH3 Domain of Human IgG1 by Combining Directed Evolution with High Throughput Sequencing

por Traxlmayr, Michael W., Hasenhindl, Christoph, Hackl, Matthias, Stadlmayr, Gerhard, Rybka, Jakub D., Borth, Nicole, Grillari, Johannes, Rüker, Florian, Obinger, Christian
Publicado 2012

An engineered protein antagonist of K-Ras/B-Raf interaction

por Kauke, Monique J., Traxlmayr, Michael W., Parker, Jillian A., Kiefer, Jonathan D., Knihtila, Ryan, McGee, John, Verdine, Greg, Mattos, Carla, Wittrup, K. Dane
Publicado 2017

Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library

por Traxlmayr, Michael W., Kiefer, Jonathan D., Srinivas, Raja R., Lobner, Elisabeth, Tisdale, Alison W., Mehta, Naveen K., Yang, Nicole J., Tidor, Bruce, Wittrup, K. Dane
Publicado 2016

Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients

por Laurent, Elisabeth, Sieber, Anna, Salzer, Benjamin, Wachernig, Anna, Seigner, Jacqueline, Lehner, Manfred, Geyeregger, René, Kratzer, Bernhard, Jäger, Ulrich, Kunert, Renate, Pickl, Winfried F., Traxlmayr, Michael W.
Publicado 2021

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins

por Yang, Nicole J., Kauke, Monique J., Sun, Fangdi, Yang, Lucy F., Maass, Katie F., Traxlmayr, Michael W., Yu, Yao, Xu, Yingda, Langer, Robert S., Anderson, Daniel G., Wittrup, K. Dane
Publicado 2017

Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential

por Paumann-Page, Martina, Kienzl, Nikolaus F., Motwani, Jyoti, Bathish, Boushra, Paton, Louise N., Magon, Nicholas J., Sevcnikar, Benjamin, Furtmüller, Paul G., Traxlmayr, Michael W., Obinger, Christian, Eccles, Mike R., Winterbourn, Christine C.
Publicado 2021

A conformation-specific ON-switch for controlling CAR T cells with an orally available drug

por Zajc, Charlotte U., Dobersberger, Markus, Schaffner, Irene, Mlynek, Georg, Pühringer, Dominic, Salzer, Benjamin, Djinović-Carugo, Kristina, Steinberger, Peter, De Sousa Linhares, Annika, Yang, Nicole J., Obinger, Christian, Holter, Wolfgang, Traxlmayr, Michael W., Lehner, Manfred
Publicado 2020

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

por Salzer, Benjamin, Schueller, Christina M., Zajc, Charlotte U., Peters, Timo, Schoeber, Michael A., Kovacic, Boris, Buri, Michelle C., Lobner, Elisabeth, Dushek, Omer, Huppa, Johannes B., Obinger, Christian, Putz, Eva M., Holter, Wolfgang, Traxlmayr, Michael W., Lehner, Manfred
Publicado 2020