Historical and new insights into pathogenesis of type 1 diabetes

por Wong, F. S., Tree, T. I.
Publicado 2019

Regulatory T cell dysfunction in type 1 diabetes: what’s broken and how can we fix it?

por Hull, Caroline M., Peakman, Mark, Tree, Timothy I. M.
Publicado 2017

Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials

por Arif, Sefina, Domingo-Vila, Clara, Pollock, Emily, Christakou, Eleni, Williams, Evangelia, Tree, Timothy I. M.
Publicado 2023

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

por Tree, Timothy I.M., Lawson, Jennifer, Edwards, Hannah, Skowera, Ania, Arif, Sefina, Roep, Bart O., Peakman, Mark
Publicado 2010

Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner

por Carty, Fiona, Corbett, Jennifer M., Cunha, João Paulo M. C. M., Reading, James L., Tree, Timothy I. M., Ting, Anthony E., Stubblefield, Samantha R., English, Karen
Publicado 2018

Persistent C‐peptide is associated with reduced hypoglycaemia but not HbA(1c) in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical p...

por Marren, S. M., Hammersley, S., McDonald, T. J., Shields, B. M., Knight, B. A., Hill, A., Bolt, R., Tree, T. I., Roep, B. O., Hattersley, A. T., Jones, A. G., Oram, R. A.
Publicado 2019

Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells

por Johnson, Matthew B., Patel, Kashyap A., De Franco, Elisa, Hagopian, William, Killian, Michael, McDonald, Timothy J., Tree, Timothy I. M., Domingo-Vila, Clara, Hudson, Michelle, Hammersley, Suzanne, Dobbs, Rebecca, Ellard, Sian, Flanagan, Sarah E., Hattersley, Andrew T., Oram, Richard A.
Publicado 2020

Low-dose IL-2 reduces IL-21(+) T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

por Zhang, Jia-Yuan, Hamey, Fiona, Trzupek, Dominik, Mickunas, Marius, Lee, Mercede, Godfrey, Leila, Yang, Jennie H. M., Pekalski, Marcin L., Kennet, Jane, Waldron-Lynch, Frank, Evans, Mark L., Tree, Timothy I. M., Wicker, Linda S., Todd, John A., Ferreira, Ricardo C.
Publicado 2022

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

por Marwaha, Ashish K, Chow, Samuel, Pesenacker, Anne M, Cook, Laura, Sun, Annika, Long, S Alice, Yang, Jennie H M, Ward-Hartstonge, Kirsten A, Williams, Evangelia, Domingo-Vila, Clara, Halani, Khalif, Harris, Kristina M, Tree, Timothy I M, Levings, Megan K, Elliott, Thomas, Tan, Rusung, Dutz, Jan P
Publicado 2021

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp(620) Risk Allele Drive the Expansion of FOXP3(+) Regulatory T Cells and PD-1 Expression

por Ferreira, Ricardo C., Castro Dopico, Xaquin, Oliveira, João J., Rainbow, Daniel B., Yang, Jennie H., Trzupek, Dominik, Todd, Sarah A., McNeill, Mhairi, Steri, Maristella, Orrù, Valeria, Fiorillo, Edoardo, Crouch, Daniel J. M., Pekalski, Marcin L., Cucca, Francesco, Tree, Tim I., Vyse, Tim J., Wicker, Linda S., Todd, John A.
Publicado 2019

Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans

por Hanna, Stephanie J., Thayer, Terri C., Robinson, Emma J. S., Vinh, Ngoc-Nga, Williams, Nigel, Landry, Laurie G., Andrews, Robert, Siah, Qi Zhuang, Leete, Pia, Wyatt, Rebecca, McAteer, Martina A., Nakayama, Maki, Wong, F. Susan, Yang, Jennie H. M., Tree, Timothy I. M., Ludvigsson, Johnny, Dayan, Colin M., Tatovic, Danijela
Publicado 2023

Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry

por Yang, Jennie H. M., Khatri, Leena, Mickunas, Marius, Williams, Evangelia, Tatovic, Danijela, Alhadj Ali, Mohammad, Young, Philippa, Moyle, Penelope, Sahni, Vishal, Wang, Ryan, Kaur, Rejbinder, Tannahill, Gillian M., Beaton, Andrew R., Gerlag, Danielle M., Savage, Caroline O. S., Napolitano Rosen, Antonella, Waldron-Lynch, Frank, Dayan, Colin M., Tree, Timothy I. M.
Publicado 2019

The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study

por Mahil, Satveer K, Bechman, Katie, Raharja, Antony, Domingo-Vila, Clara, Baudry, David, Brown, Matthew A, Cope, Andrew P, Dasandi, Tejus, Graham, Carl, Lechmere, Thomas, Malim, Michael H, Meynell, Freya, Pollock, Emily, Seow, Jeffery, Sychowska, Kamila, Barker, Jonathan N, Norton, Sam, Galloway, James B, Doores, Katie J, Tree, Timothy I M, Smith, Catherine H
Publicado 2021

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

por Todd, John A., Evangelou, Marina, Cutler, Antony J., Pekalski, Marcin L., Walker, Neil M., Stevens, Helen E., Porter, Linsey, Smyth, Deborah J., Rainbow, Daniel B., Ferreira, Ricardo C., Esposito, Laura, Hunter, Kara M. D., Loudon, Kevin, Irons, Kathryn, Yang, Jennie H., Bell, Charles J. M., Schuilenburg, Helen, Heywood, James, Challis, Ben, Neupane, Sankalpa, Clarke, Pamela, Coleman, Gillian, Dawson, Sarah, Goymer, Donna, Anselmiova, Katerina, Kennet, Jane, Brown, Judy, Caddy, Sarah L., Lu, Jia, Greatorex, Jane, Goodfellow, Ian, Wallace, Chris, Tree, Tim I., Evans, Mark, Mander, Adrian P., Bond, Simon, Wicker, Linda S., Waldron-Lynch, Frank
Publicado 2016