(13)C tracer analysis reveals the landscape of metabolic checkpoints in human CD8(+) T cell differentiation and exhaustion

por Kirchmair, Alexander, Nemati, Niloofar, Lamberti, Giorgia, Trefny, Marcel, Krogsdam, Anne, Siller, Anita, Hörtnagl, Paul, Schumacher, Petra, Sopper, Sieghart, Sandbichler, Adolf, Zippelius, Alfred, Ghesquière, Bart, Trajanoski, Zlatko
Publicado 2023

Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity

por Fernandez-Rodriguez, Laura, Cianciaruso, Chiara, Bill, Ruben, Trefny, Marcel P, Klar, Richard, Kirchhammer, Nicole, Buchi, Mélanie, Festag, Julia, Michel, Sven, Kohler, Rainer H, Jones, Elham, Maaske, Andre, vom Berg, Johannes, Kobold, Sebastian, Kashyap, Abhishek S, Jaschinski, Frank, Dixon, Karen O, Pittet, Mikael J, Zippelius, Alfred
Publicado 2023

GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses

por Kashyap, Abhishek S., Fernandez-Rodriguez, Laura, Zhao, Yun, Monaco, Gianni, Trefny, Marcel P., Yoshida, Naohiro, Martin, Kea, Sharma, Ashwani, Olieric, Natacha, Shah, Pankaj, Stanczak, Michal, Kirchhammer, Nicole, Park, Sung-Moo, Wieckowski, Sebastien, Laubli, Heinz, Zagani, Rachid, Kasenda, Benjamin, Steinmetz, Michel O., Reinecker, Hans-Christian, Zippelius, Alfred
Publicado 2019

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

por Wang, Haiping, Franco, Fabien, Tsui, Yao-Chen, Xie, Xin, Trefny, Marcel P., Zappasodi, Roberta, Mohmood, Syed Raza, Fernández-García, Juan, Tsai, Chin-Hsien, Schulze, Isabell, Picard, Florence, Meylan, Etienne, Silverstein, Roy, Goldberg, Ira, Fendt, Sarah-Maria, Wolchok, Jedd D., Merghoub, Taha, Jandus, Camilla, Zippelius, Alfred, Ho, Ping-Chih
Publicado 2020

N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer

por Auf der Maur, Priska, Trefny, Marcel P., Baumann, Zora, Vulin, Milica, Correia, Ana Luisa, Diepenbruck, Maren, Kramer, Nicolas, Volkmann, Katrin, Preca, Bogdan-Tiberius, Ramos, Pedro, Leroy, Cedric, Eichlisberger, Tobias, Buczak, Katarzyna, Zilli, Federica, Okamoto, Ryoko, Rad, Roland, Jensen, Michael Rugaard, Fritsch, Christine, Zippelius, Alfred, Stadler, Michael B., Bentires-Alj, Mohamed
Publicado 2023

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

por Stanczak, Michal A., Mantuano, Natalia Rodrigues, Kirchhammer, Nicole, Sanin, David E., Jacob, Francis, Coelho, Ricardo, Everest-Dass, Arun V., Wang, Jinyu, Trefny, Marcel P., Monaco, Gianni, Bärenwaldt, Anne, Gray, Melissa A., Petrone, Adam, Kashyap, Abhishek S., Glatz, Katharina, Kasenda, Benjamin, Normington, Karl, Broderick, James, Peng, Li, Pearce, Oliver M.T., Pearce, Erika L., Bertozzi, Carolyn R., Zippelius, Alfred, Läubli, Heinz
Publicado 2022

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

por Trefny, Marcel P., Kirchhammer, Nicole, Auf der Maur, Priska, Natoli, Marina, Schmid, Dominic, Germann, Markus, Fernandez Rodriguez, Laura, Herzig, Petra, Lötscher, Jonas, Akrami, Maryam, Stinchcombe, Jane C., Stanczak, Michal A., Zingg, Andreas, Buchi, Melanie, Roux, Julien, Marone, Romina, Don, Leyla, Lardinois, Didier, Wiese, Mark, Jeker, Lukas T., Bentires-Alj, Mohamed, Rossy, Jérémie, Thommen, Daniela S., Griffiths, Gillian M., Läubli, Heinz, Hess, Christoph, Zippelius, Alfred
Publicado 2023