Superior reductions in hepatic steatosis and fibrosis with co-administration of a glucagon-like peptide-1 receptor agonist and obeticholic acid in mice

por Jouihan, Hani, Will, Sarah, Guionaud, Silvia, Boland, Michelle L., Oldham, Stephanie, Ravn, Peter, Celeste, Anthony, Trevaskis, James L.
Publicado 2017

A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling

por Butler, Andrew A., Girardet, Clemence, Mavrikaki, Maria, Trevaskis, James L., Macarthur, Heather, Marks, Daniel L., Farr, Susan A.
Publicado 2017

A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice

por Hornigold, David C., Roth, Emma, Howard, Victor, Will, Sarah, Oldham, Stephanie, Coghlan, Matthew P., Blouet, Clemence, Trevaskis, James L.
Publicado 2018

Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction

por Boland, Michelle L, Oldham, Stephanie, Boland, Brandon B, Will, Sarah, Lapointe, Jean-Martin, Guionaud, Silvia, Rhodes, Christopher J, Trevaskis, James L
Publicado 2018

Lack of an association between clinical INSTI-related body weight gain and direct interference with MC4 receptor (MC4R), a key central regulator of body weight

por McMahon, Carrie, Trevaskis, James L., Carter, Christoph, Holsapple, Kevin, White, Kirsten, Das, Moupali, Collins, Sean, Martin, Hal, Burns-Naas, Leigh Ann
Publicado 2020

The PYY/Y2R-Deficient Mouse Responds Normally to High-Fat Diet and Gastric Bypass Surgery

por Boland, Brandon, Mumphrey, Michael B., Hao, Zheng, Gill, Benji, Townsend, R. Leigh, Yu, Sangho, Münzberg, Heike, Morrison, Christopher D., Trevaskis, James L., Berthoud, Hans-Rudolf
Publicado 2019

Targeting lipid biosynthesis pathways for hepatitis B virus cure

por Hyrina, Anastasia, Burdette, Dara, Song, Zhijuan, Ramirez, Ricardo, Okesli-Armlovich, Ayse, Vijayakumar, Archana, Bates, Jamie, Trevaskis, James L., Fletcher, Simon P., Lee, William A., Holdorf, Meghan M.
Publicado 2022

Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis

por Vijayakumar, Archana, Okesli‐Armlovich, Ayse, Wang, Ting, Olson, Isabel, Seung, Minji, Kusam, Saritha, Hollenback, David, Mahadevan, Sangeetha, Marchand, Bruno, Toteva, Maria, Breckenridge, David G., Trevaskis, James L., Bates, Jamie
Publicado 2022

Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy

por Valdecantos, M. Pilar, Ruiz, Laura, Pardo, Virginia, Castro-Sanchez, Luis, García-Monzón, Carmelo, Lanzón, Borja, Rupérez, Javier, Barbas, Coral, Naylor, Jaqueline, Trevaskis, James L., Grimsby, Joseph, Rondinone, Cristina M., Valverde, Ángela M.
Publicado 2018

Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice

por Boland, Brandon B., Mumphrey, Michael B., Hao, Zheng, Townsend, R. Leigh, Gill, Benji, Oldham, Stephanie, Will, Sarah, Morrison, Christopher D., Yu, Sangho, Münzberg, Heike, Rhodes, Christopher J., Trevaskis, James L., Berthoud, Hans-Rudolf
Publicado 2019

Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy

por Roth, Emma, Benoit, Simon, Quentin, Baptiste, Lam, Brian, Will, Sarah, Ma, Marcella, Heeley, Nick, Darwish, Tamana, Shrestha, Yashaswi, Gribble, Fiona, Reimann, Frank, Pshenichnaya, Irina, Yeo, Giles, Baker, David J., Trevaskis, James L., Blouet, Clemence
Publicado 2020

Rapid Development of Non-Alcoholic Steatohepatitis in Psammomys obesus (Israeli Sand Rat)

por Spolding, Briana, Connor, Timothy, Wittmer, Carrie, Abreu, Lelia L. F., Kaspi, Antony, Ziemann, Mark, Kaur, Gunveen, Cooper, Adrian, Morrison, Shona, Lee, Scott, Sinclair, Andrew, Gibert, Yann, Trevaskis, James L., Roth, Jonathon D., El-Osta, Assam, Standish, Richard, Walder, Ken
Publicado 2014

Improved Glucose Control and Reduced Body Weight in Rodents with Dual Mechanism of Action Peptide Hybrids

por Trevaskis, James L., Mack, Christine M., Sun, Chengzao, Soares, Christopher J., D’Souza, Lawrence J., Levy, Odile E., Lewis, Diane Y., Jodka, Carolyn M., Tatarkiewicz, Krystyna, Gedulin, Bronislava, Gupta, Swati, Wittmer, Carrie, Hanley, Michael, Forood, Bruce, Parkes, David G., Ghosh, Soumitra S.
Publicado 2013

Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source

por Boland, Michelle L, Oró, Denise, Tølbøl, Kirstine S, Thrane, Sebastian T, Nielsen, Jens Christian, Cohen, Taylor S, Tabor, David E, Fernandes, Fiona, Tovchigrechko, Andrey, Veidal, Sanne S, Warrener, Paul, Sellman, Bret R, Jelsing, Jacob, Feigh, Michael, Vrang, Niels, Trevaskis, James L, Hansen, Henrik H
Publicado 2019

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

por Hansen, Henrik H., Ægidius, Helene M., Oró, Denise, Evers, Simon S., Heebøll, Sara, Eriksen, Peter Lykke, Thomsen, Karen Louise, Bengtsson, Anja, Veidal, Sanne S., Feigh, Michel, Suppli, Malte P., Knop, Filip K., Grønbæk, Henning, Miranda, Diego, Trevaskis, James L., Vrang, Niels, Jelsing, Jacob, Rigbolt, Kristoffer T. G.
Publicado 2020

Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.

por Boland, Michelle L., Laker, Rhianna C., Mather, Karly, Nawrocki, Arkadiusz, Oldham, Stephanie, Boland, Brandon B., Lewis, Hilary, Conway, James, Naylor, Jacqueline, Guionaud, Silvia, Feigh, Michael, Veidal, Sanne S., Lantier, Louise, McGuinness, Owen P., Grimsby, Joseph, Rondinone, Cristina M., Jermutus, Lutz, Larsen, Martin R., Trevaskis, James L., Rhodes, Christopher J.
Publicado 2020

Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment

por Chodorge, Matthieu, Celeste, Anthony J., Grimsby, Joseph, Konkar, Anish, Davidsson, Pia, Fairman, David, Jenkinson, Lesley, Naylor, Jacqueline, White, Nicholas, Seaman, Jonathan C., Dickson, Karen, Kemp, Benjamin, Spooner, Jennifer, Rossy, Emmanuel, Hornigold, David C., Trevaskis, James L., Bond, Nicholas J., London, Timothy B., Buchanan, Andrew, Vaughan, Tristan, Rondinone, Cristina M., Osbourn, Jane K.
Publicado 2018

Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding

por Cheng, Wenwen, Gonzalez, Ian, Pan, Warren, Tsang, Anthony H., Adams, Jessica, Ndoka, Ermelinda, Gordian, Desiree, Khoury, Basma, Roelofs, Karen, Evers, Simon S., MacKinnon, Andrew, Wu, Shuangcheng, Frikke-Schmidt, Henriette, Flak, Jonathan N., Trevaskis, James L., Rhodes, Christopher J., Fukada, So-ichiro, Seeley, Randy J., Sandoval, Darleen A., Olson, David P., Blouet, Clemence, Myers, Martin G.
Publicado 2020

Peptide-YY(3-36)/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergis...

por Boland, Brandon B., Laker, Rhianna C., O'Brien, Siobhan, Sitaula, Sadichha, Sermadiras, Isabelle, Nielsen, Jens Christian, Barkholt, Pernille, Roostalu, Urmas, Hecksher-Sørensen, Jacob, Sejthen, Sara Rubek, Thorbek, Ditte Dencker, Suckow, Arthur, Burmeister, Nicole, Oldham, Stephanie, Will, Sarah, Howard, Victor G., Gill, Benji M., Newton, Philip, Naylor, Jacqueline, Hornigold, David C., Austin, Jotham, Lantier, Louise, McGuinness, Owen P., Trevaskis, James L., Grimsby, Joseph S., Rhodes, Christopher J.
Publicado 2021