First‐in‐Human Studies of Pharmacokinetics and Safety of Utreloxastat (PTC857), a Novel 15‐Lipooxygenase Inhibitor for the Treatment of Amyotrophic Lateral Sclerosis

por Gao, Lan, Giannousis, Peter, Thoolen, Martin, Kaushik, Diksha, Latham, Joey, Tansy, Aaron, Ma, Jiyuan, Johnston, Mayzie, Dali, Mandar, Golden, Lee, Klein, Matthew, Kong, Ronald, Trimmer, Jeffrey
Publicado 2022

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

por Hinman, Andrew, Holst, Charles R., Latham, Joey C., Bruegger, Joel J., Ulas, Gözde, McCusker, Kevin P., Amagata, Akiko, Davis, Dana, Hoff, Kevin G., Kahn-Kirby, Amanda H., Kim, Virna, Kosaka, Yuko, Lee, Edgar, Malone, Stephanie A., Mei, Janet J., Richards, Steve James, Rivera, Veronica, Miller, Guy, Trimmer, Jeffrey K., Shrader, William D.
Publicado 2018

Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy

por Kahn-Kirby, Amanda H., Amagata, Akiko, Maeder, Celine I., Mei, Janet J., Sideris, Steve, Kosaka, Yuko, Hinman, Andrew, Malone, Stephanie A., Bruegger, Joel J., Wang, Leslie, Kim, Virna, Shrader, William D., Hoff, Kevin G., Latham, Joey C., Ashley, Euan A., Wheeler, Matthew T., Bertini, Enrico, Carrozzo, Rosalba, Martinelli, Diego, Dionisi-Vici, Carlo, Chapman, Kimberly A., Enns, Gregory M., Gahl, William, Wolfe, Lynne, Saneto, Russell P., Johnson, Simon C., Trimmer, Jeffrey K., Klein, Matthew B., Holst, Charles R.
Publicado 2019