Targeting Cartilage Degradation in Osteoarthritis

por McClurg, Oliver, Tinson, Ryan, Troeberg, Linda
Publicado 2021

The Extracellular Matrix of Articular Cartilage Controls the Bioavailability of Pericellular Matrix-Bound Growth Factors to Drive Tissue Homeostasis and Repair

por Vincent, Tonia L., McClurg, Oliver, Troeberg, Linda
Publicado 2022

Editorial: Proteoglycans and Glycosaminoglycan Modification in Immune Regulation and Inflammation

por Reijmers, Rogier M., Troeberg, Linda, Lord, Megan S., Petrey, Aaron C.
Publicado 2020

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity

por Lo Cicero, Alessandra, Majkowska, Iwona, Nagase, Hideaki, Di Liegro, Italia, Troeberg, Linda
Publicado 2012

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

por Troeberg, Linda, Mulloy, Barbara, Ghosh, Peter, Lee, Meng-Huee, Murphy, Gillian, Nagase, Hideaki
Publicado 2012

Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity

por Doherty, Christine M., Visse, Robert, Dinakarpandian, Deendayal, Strickland, Dudley K., Nagase, Hideaki, Troeberg, Linda
Publicado 2016

Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity

por Fowkes, Milan M., Troeberg, Linda, Brennan, Paul E., Vincent, Tonia L., Meldal, Morten, Lim, Ngee H.
Publicado 2023

Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3

por Chanalaris, Anastasios, Doherty, Christine, Marsden, Brian D., Bambridge, Gabriel, Wren, Stephen P., Nagase, Hideaki, Troeberg, Linda
Publicado 2017

Inhibition of Shedding of Low‐Density Lipoprotein Receptor–Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

por Yamamoto, Kazuhiro, Santamaria, Salvatore, Botkjaer, Kenneth A., Dudhia, Jayesh, Troeberg, Linda, Itoh, Yoshifumi, Murphy, Gillian, Nagase, Hideaki
Publicado 2017

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor

por Scilabra, Simone D., Pigoni, Martina, Pravatá, Veronica, Schätzl, Tobias, Müller, Stephan A., Troeberg, Linda, Lichtenthaler, Stefan F.
Publicado 2018

TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1

por Carreca, Anna P., Pravatà, Veronica M., Markham, Matthew, Bonelli, Simone, Murphy, Gillian, Nagase, Hideaki, Troeberg, Linda, Scilabra, Simone D.
Publicado 2020

ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α(2)δ Subunits, and Enables Calcium Current Enhancement

por Kadurin, Ivan, Dahimene, Shehrazade, Page, Karen M, Ellaway, Joseph I J, Chaggar, Kanchan, Troeberg, Linda, Nagase, Hideaki, Dolphin, Annette C
Publicado 2022

Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics

por Calligaris, Matteo, Yang, Chun Y., Bonelli, Simone, Spanò, Donatella Pia, Müller, Stephan A., Lichtenthaler, Stefan F., Troeberg, Linda, Scilabra, Simone D.
Publicado 2023

Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3

por Troeberg, Linda, Lazenbatt, Christopher, Anower-E-Khuda, Md. Ferdous, Freeman, Craig, Federov, Oleg, Habuchi, Hiroko, Habuchi, Osami, Kimata, Koji, Nagase, Hideaki
Publicado 2014

Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State

por Yang, Chun-Yao, Bonelli, Simone, Calligaris, Matteo, Carreca, Anna Paola, Müller, Stephan A., Lichtenthaler, Stefan F., Troeberg, Linda, Scilabra, Simone D.
Publicado 2022

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

por Yamamoto, Kazuhiro, Okano, Hiroshi, Miyagawa, Wakako, Visse, Robert, Shitomi, Yasuyuki, Santamaria, Salvatore, Dudhia, Jayesh, Troeberg, Linda, Strickland, Dudley K., Hirohata, Satoshi, Nagase, Hideaki
Publicado 2016

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells

por Mohammed, Rebar N., Wehenkel, Sophie C., Galkina, Elena V., Yates, Emma-Kate, Preece, Graham, Newman, Andrew, Watson, H. Angharad, Ohme, Julia, Bridgeman, John S., Durairaj, Ruban R. P., Moon, Owen R., Ladell, Kristin, Miners, Kelly L., Dolton, Garry, Troeberg, Linda, Kashiwagi, Masahide, Murphy, Gillian, Nagase, Hideaki, Price, David A., Matthews, R. James, Knäuper, Vera, Ager, Ann
Publicado 2019

Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method

por Paskins, Zoe, Farmer, Clare E, Manning, Fay, Andersson, David A, Barlow, Tim, Bishop, Felicity L, Brown, Christopher A, Clark, Amanda, Clark, Emma M, Dulake, Debra, Gulati, Malvika, Le Maitre, Christine L, Jones, Richard K, Loughlin, John, Mason, Deborah J, McCarron, Maura, Millar, Neil L, Pandit, Hemant, Peat, George, Richardson, Stephen M, Salt, Emma J, Taylor, E Jane, Troeberg, Linda, Wilcox, Ruth K, Wise, Elspeth, Wilkinson, Colin, Watt, Fiona E
Publicado 2022