Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease

por Avrutsky, Maria I., Troy, Carol M.
Publicado 2021

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

por Tamayev, Robert, Akpan, Nsikan, Arancio, Ottavio, Troy, Carol M, D’Adamio, Luciano
Publicado 2012

Caspase-2 is required for dendritic spine and behavioral alterations in J20 APP transgenic mice

por Pozueta, Julio, Lefort, Roger, Ribe, Elena M., Troy, Carol M., Aran-cio, Ottavio, Shelanski, Michael
Publicado 2013

Noninvasive Ophthalmic Imaging Measures Retinal Degeneration and Vision Deficits in Ndufs4(−/−) Mouse Model of Mitochondrial Complex I Deficiency

por Avrutsky, Maria I., Lawson, Jacqueline M., Smart, Jade E., Chen, Claire W., Troy, Carol M.
Publicado 2022

Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion

por Avrutsky, Maria I., Chen, Claire W., Lawson, Jacqueline M., Snipas, Scott J., Salvesen, Guy S., Troy, Carol M.
Publicado 2023

Neuronal caspase 2 activity and function requires RAIDD, but not PIDD

por Ribe, Elena M., Jean, Ying Y., Goldstein, Rebecca L., Manzl, Claudia, Stefanis, Leonidas, Villunger, Andreas, Troy, Carol M.
Publicado 2012

Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline

por Colón Ortiz, Crystal, Neal, Albertine M., Avrutsky, Maria I., Choi, Monica, Smart, Jade, Lawson, Jacqueline, Troy, Carol M.
Publicado 2022

Correction: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline

por Colón Ortiz, Crystal, Neal, Albertine M., Avrutsky, Maria I., Choi, Monica, Smart, Jade, Lawson, Jacqueline, Troy, Carol M.
Publicado 2022

Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice

por Montroull, Laura E., Rothbard, Deborah E., Kanal, Hur D., D’Mello, Veera, Dodson, Vincent, Troy, Carol M., Zanin, Juan P., Levison, Steven W., Friedman, Wilma J.
Publicado 2020

Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

por Avrutsky, Maria I., Ortiz, Crystal Colón, Johnson, Kendra V., Potenski, Anna M., Chen, Claire W., Lawson, Jacqueline M., White, Alexandra J., Yuen, Stephanie K., Morales, Fatima N., Canepa, Elisa, Snipas, Scott, Salvesen, Guy S., Jean, Ying Y., Troy, Carol M.
Publicado 2020

Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

por Avrutsky, Maria I., Ortiz, Crystal Colón, Johnson, Kendra V., Potenski, Anna M., Chen, Claire W., Lawson, Jacqueline M., White, Alexandra J., Yuen, Stephanie K., Morales, Fatima N., Canepa, Elisa, Snipas, Scott, Salvesen, Guy S., Jean, Ying Y., Troy, Carol M.
Publicado 2020

Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics

por Bosc, Elodie, Anastasie, Julie, Soualmia, Feryel, Coric, Pascale, Kim, Ju Youn, Wang, Lily Q., Lacin, Gullen, Zhao, Kaitao, Patel, Ronak, Duplus, Eric, Tixador, Philippe, Sproul, Andrew A., Brugg, Bernard, Reboud-Ravaux, Michelle, Troy, Carol M., Shelanski, Michael L., Bouaziz, Serge, Karin, Michael, El Amri, Chahrazade, Jacotot, Etienne D.
Publicado 2022

Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant

por Di Donato, Nataliya, Jean, Ying Y., Maga, A. Murat, Krewson, Briana D., Shupp, Alison B., Avrutsky, Maria I., Roy, Achira, Collins, Sarah, Olds, Carissa, Willert, Rebecca A., Czaja, Agnieszka M., Johnson, Rachel, Stover, Jessi A., Gottlieb, Steven, Bartholdi, Deborah, Rauch, Anita, Goldstein, Amy, Boyd-Kyle, Victoria, Aldinger, Kimberly A., Mirzaa, Ghayda M., Nissen, Anke, Brigatti, Karlla W., Puffenberger, Erik G., Millen, Kathleen J., Strauss, Kevin A., Dobyns, William B., Troy, Carol M., Jinks, Robert N.
Publicado 2016

Apoptotic cell death in disease—Current understanding of the NCCD 2023

por Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco E., Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K. -M., Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravichandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S., Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, Galluzzi, Lorenzo
Publicado 2023