Safety, Tolerability, and Pharmacokinetics of the β‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitor Verubecestat (MK‐8931) in Healthy Elderly Male and Female Subjects...

por Forman, Mark, Palcza, John, Tseng, Jack, Stone, Julie A., Walker, Brittany, Swearingen, Dennis, Troyer, Matthew D., Dockendorf, Marissa F.
Publicado 2019

A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls

por Vissers, Maurits F. J. M., Troyer, Matthew D., Thijssen, Eva, Pereira, Diana R., Heuberger, | Jules A. A. C., Groeneveld, Geert Jan, Huntwork‐Rodriguez, Sarah
Publicado 2023

Asenapine pharmacokinetics and tolerability in a pediatric population

por Dogterom, Peter, Riesenberg, Robert, de Greef, Rik, Dennie, Justin, Johnson, Martin, Pilla Reddy, Venkatesh, Miltenburg, André MM, Findling, Robert L, Jakate, Abhijeet, Carrothers, Timothy J, Troyer, Matthew D
Publicado 2018

On-the-road driving performance the morning after bedtime use of suvorexant 15 and 30 mg in healthy elderly

por Vermeeren, Annemiek, Vets, Eva, Vuurman, Eric F.P.M., Van Oers, Anita C.M., Jongen, Stefan, Laethem, Tine, Heirman, Ingeborg, Bautmans, An, Palcza, John, Li, Xiadong, Troyer, Matthew D., Wrishko, Rebecca, McCrea, Jacqueline, Sun, Hong
Publicado 2016

Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients

por Bhalla, Akhil, Ravi, Ritesh, Fang, Meng, Arguello, Annie, Davis, Sonnet S., Chiu, Chi-Lu, Blumenfeld, Jessica R., Nguyen, Hoang N., Earr, Timothy K., Wang, Junhua, Astarita, Giuseppe, Zhu, Yuda, Fiore, Damian, Scearce-Levie, Kimberly, Diaz, Dolores, Cahan, Heather, Troyer, Matthew D., Harris, Jeffrey M., Escolar, Maria L.
Publicado 2020

Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib...

por Vissers, Maurits F. J. M., Heuberger, Jules A. A. C., Groeneveld, Geert Jan, Oude Nijhuis, Jerome, De Deyn, Peter Paul, Hadi, Salah, Harris, Jeffrey, Tsai, Richard M., Cruz‐Herranz, Andres, Huang, Fen, Tong, Vincent, Erickson, Rebecca, Zhu, Yuda, Scearce‐Levie, Kimberly, Hsiao‐Nakamoto, Jennifer, Tang, Xinyan, Chang, Megan, Fox, Brian M., Estrada, Anthony A., Pomponio, Robert J., Alonso‐Alonso, Miguel, Zilberstein, Moshe, Atassi, Nazem, Troyer, Matthew D., Ho, Carole
Publicado 2022

Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme

por Arguello, Annie, Mahon, Cathal S., Calvert, Meredith E.K., Chan, Darren, Dugas, Jason C., Pizzo, Michelle E., Thomsen, Elliot R., Chau, Roni, Damo, Lorna A., Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N., Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C., Wang, Junhua, Dennis, Mark S., Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R., Lewcock, Joseph W., Sanchez, Pascal E., Troyer, Matthew D., Harris, Jeffrey M., Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J., Thorne, Robert G., Henry, Anastasia G., Kariolis, Mihalis S.
Publicado 2022