Functional studies of GWAS variants are gaining momentum

por Lichou, Florence, Trynka, Gosia
Publicado 2020

From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases

por Cano-Gamez, Eddie, Trynka, Gosia
Publicado 2020

Immunogenomic approaches to understand the function of immune disease variants

por Glinos, Dafni A., Soskic, Blagoje, Trynka, Gosia
Publicado 2017

Tissue-Specific Enrichment of Lymphoma Risk Loci in Regulatory Elements

por Hayes, James E., Trynka, Gosia, Vijai, Joseph, Offit, Kenneth, Raychaudhuri, Soumya, Klein, Robert J.
Publicado 2015

Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation

por Glinos, Dafni A., Soskic, Blagoje, Williams, Cayman, Kennedy, Alan, Jostins, Luke, Sansom, David M., Trynka, Gosia
Publicado 2020

Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia

por Washer, Sam J., Perez-Alcantara, Marta, Chen, Yixi, Steer, Juliette, James, William S., Trynka, Gosia, Bassett, Andrew R., Cowley, Sally A.
Publicado 2022

Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci

por Trynka, Gosia, Westra, Harm-Jan, Slowikowski, Kamil, Hu, Xinli, Xu, Han, Stranger, Barbara E., Klein, Robert J., Han, Buhm, Raychaudhuri, Soumya
Publicado 2015

Potential Celiac Patients: A Model of Celiac Disease Pathogenesis

por Sperandeo, Maria Pia, Tosco, Antonella, Izzo, Valentina, Tucci, Francesca, Troncone, Riccardo, Auricchio, Renata, Romanos, Jihane, Trynka, Gosia, Auricchio, Salvatore, Jabri, Bana, Greco, Luigi
Publicado 2011

Evaluation of European coeliac disease risk variants in a north Indian population

por Senapati, Sabyasachi, Gutierrez-Achury, Javier, Sood, Ajit, Midha, Vandana, Szperl, Agata, Romanos, Jihane, Zhernakova, Alexandra, Franke, Lude, Alonso, Santos, Thelma, B K, Wijmenga, Cisca, Trynka, Gosia
Publicado 2015

Complex nature of SNP genotype effects on gene expression in primary human leucocytes

por Heap, Graham A, Trynka, Gosia, Jansen, Ritsert C, Bruinenberg, Marcel, Swertz, Morris A, Dinesen, Lotte C, Hunt, Karen A, Wijmenga, Cisca, vanHeel, David A, Franke, Lude
Publicado 2009

The influence of a short-term gluten-free diet on the human gut microbiome

por Bonder, Marc Jan, Tigchelaar, Ettje F., Cai, Xianghang, Trynka, Gosia, Cenit, Maria C., Hrdlickova, Barbara, Zhong, Huanzi, Vatanen, Tommi, Gevers, Dirk, Wijmenga, Cisca, Wang, Yang, Zhernakova, Alexandra
Publicado 2016

Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

por Gutierrez-Achury, Javier, Zhernakova, Alexandra, Pulit, Sara L., Trynka, Gosia, Hunt, Karen A., Romanos, Jihane, Raychaudhuri, Soumya, van Heel, David A., Wijmenga, Cisca, de Bakker, Paul I.W.
Publicado 2015

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells

por Lynall, Mary-Ellen, Soskic, Blagoje, Hayhurst, James, Schwartzentruber, Jeremy, Levey, Daniel F., Pathak, Gita A., Polimanti, Renato, Gelernter, Joel, Stein, Murray B., Trynka, Gosia, Clatworthy, Menna R., Bullmore, Ed
Publicado 2022

Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases

por Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Rowan, Wendy C., Nakic, Nikolina, Esparza-Gordillo, Jorge, Bossini-Castillo, Lara, Tough, David F., Larminie, Christopher GC, Bronson, Paola G., Willé, David, Trynka, Gosia
Publicado 2019

Variants in Neuropeptide Y Receptor 1 and 5 Are Associated with Nutrient-Specific Food Intake and Are Under Recent Selection in Europeans

por Elbers, Clara C., de Kovel, Carolien G. F., van der Schouw, Yvonne T., Meijboom, Juliaan R., Bauer, Florianne, Grobbee, Diederick E., Trynka, Gosia, van Vliet-Ostaptchouk, Jana V., Wijmenga, Cisca, Onland-Moret, N. Charlotte
Publicado 2009

Coloc-stats: a unified web interface to perform colocalization analysis of genomic features

por Simovski, Boris, Kanduri, Chakravarthi, Gundersen, Sveinung, Titov, Dmytro, Domanska, Diana, Bock, Christoph, Bossini-Castillo, Lara, Chikina, Maria, Favorov, Alexander, Layer, Ryan M, Mironov, Andrey A, Quinlan, Aaron R, Sheffield, Nathan C, Trynka, Gosia, Sandve, Geir K
Publicado 2018

Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4(+) Effector Memory T Cells

por Hu, Xinli, Kim, Hyun, Raj, Towfique, Brennan, Patrick J., Trynka, Gosia, Teslovich, Nikola, Slowikowski, Kamil, Chen, Wei-Min, Onengut, Suna, Baecher-Allan, Clare, De Jager, Philip L., Rich, Stephen S., Stranger, Barbara E., Brenner, Michael B., Raychaudhuri, Soumya
Publicado 2014

Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4(+) T cells to cytokines

por Cano-Gamez, Eddie, Soskic, Blagoje, Roumeliotis, Theodoros I., So, Ernest, Smyth, Deborah J., Baldrighi, Marta, Willé, David, Nakic, Nikolina, Esparza-Gordillo, Jorge, Larminie, Christopher G. C., Bronson, Paola G., Tough, David F., Rowan, Wendy C., Choudhary, Jyoti S., Trynka, Gosia
Publicado 2020

Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity

por Gutierrez-Achury, Javier, Romanos, Jihane, Bakker, Sjoerd F., Kumar, Vinod, de Haas, Esther C., Trynka, Gosia, Ricaño-Ponce, Isis, Steck, Andrea, Chen, Wei-Min, Onengut-Gumuscu, Suna, Simsek, Suat, Rewers, Marian, Mulder, Chris J., Liu, Ed, Rich, Stephen S., Wijmenga, Cisca
Publicado 2015

Immune disease variants modulate gene expression in regulatory CD4(+) T cells

por Bossini-Castillo, Lara, Glinos, Dafni A., Kunowska, Natalia, Golda, Gosia, Lamikanra, Abigail A., Spitzer, Michaela, Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Cattermole, Claire, Alasoo, Kaur, Mann, Alice, Kundu, Kousik, Lorenc, Anna, Soranzo, Nicole, Dunham, Ian, Roberts, David J., Trynka, Gosia
Publicado 2022