Unveiling the noncanonical activation mechanism of CDKs: insights from recent structural studies

por Li, Tao, Tang, Hui-Chi, Tsai, Kuang-Lei
Publicado 2023

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

por Tsai, Kuang-Lei, Sato, Shigeo, Tomomori-Sato, Chieri, Conaway, Ronald C., Conaway, Joan W., Asturias, Francisco J.
Publicado 2013

Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification

por Tsai, Kuang-Lei, Sun, Yuh-Ju, Huang, Cheng-Yang, Yang, Jer-Yen, Hung, Mien-Chie, Hsiao, Chwan-Deng
Publicado 2007

The crystal structure of a replicative hexameric helicase DnaC and its complex with single-stranded DNA

por Lo, Yu-Hua, Tsai, Kuang-Lei, Sun, Yuh-Ju, Chen, Wei-Ti, Huang, Cheng-Yang, Hsiao, Chwan-Deng
Publicado 2009

The Hypoxia-Adenosine Link during Myocardial Ischemia—Reperfusion Injury

por Ruan, Wei, Ma, Xinxin, Bang, In Hyuk, Liang, Yafen, Muehlschlegel, Jochen Daniel, Tsai, Kuang-Lei, Mills, Tingting W., Yuan, Xiaoyi, Eltzschig, Holger K.
Publicado 2022

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

por Brignole, Edward J, Tsai, Kuang-Lei, Chittuluru, Johnathan, Li, Haoran, Aye, Yimon, Penczek, Pawel A, Stubbe, JoAnne, Drennan, Catherine L, Asturias, Francisco
Publicado 2018

Structure of a Designed Protein Cage that Self-Assembles into a Highly Porous Cube

por Lai, Yen-Ting, Reading, Eamonn, Hura, Greg L., Tsai, Kuang-Lei, Laganowsky, Arthur, Asturias, Francisco J., Tainer, John A., Robinson, Carol V., Yeates, Todd O.
Publicado 2014

Structure of TFIIK for phosphorylation of CTD of RNA polymerase II

por van Eeuwen, Trevor, Li, Tao, Kim, Hee Jong, Gorbea Colón, Jose J., Parker, Mitchell I., Dunbrack, Roland L., Garcia, Benjamin A., Tsai, Kuang-Lei, Murakami, Kenji
Publicado 2021

Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module

por Li, Yi-Chuan, Chao, Ti-Chun, Kim, Hee Jong, Cholko, Timothy, Chen, Shin-Fu, Li, Guojie, Snyder, Laura, Nakanishi, Kotaro, Chang, Chia-en, Murakami, Kenji, Garcia, Benjamin A., Boyer, Thomas G., Tsai, Kuang-Lei
Publicado 2021

RNA m(6)A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability

por Xiong, Feng, Wang, Ruoyu, Lee, Joo-Hyung, Li, Shenglan, Chen, Shin-Fu, Liao, Zian, Hasani, Lana Al, Nguyen, Phuoc T., Zhu, Xiaoyu, Krakowiak, Joanna, Lee, Dung-Fang, Han, Leng, Tsai, Kuang-Lei, Liu, Ying, Li, Wenbo
Publicado 2021

Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies

por Tu, Jian, Huo, Zijun, Yu, Yao, Zhu, Dandan, Xu, An, Huang, Mo-Fan, Hu, Ruifeng, Wang, Ruoyu, Gingold, Julian A., Chen, Yi-Hung, Tsai, Kuang-Lei, Forcioli-Conti, Nicolas R., Huang, Sarah X. L., Webb, Thomas R., Su, Jie, Bazer, Danielle A., Jia, Peilin, Yustein, Jason T., Wang, Lisa L., Hung, Mien-Chie, Zhao, Zhongming, Huff, Chad D., Shen, Jingnan, Zhao, Ruiying, Lee, Dung-Fang
Publicado 2022