Illuminating the genome-wide activity of genome editors for safe and effective therapeutics

por Cheng, Yong, Tsai, Shengdar Q.
Publicado 2018

Easy-Prime: a machine learning–based prime editor design tool

por Li, Yichao, Chen, Jingjing, Tsai, Shengdar Q., Cheng, Yong
Publicado 2021

FLASH Assembly of TALENs Enables High-Throughput Genome Editing

por Reyon, Deepak, Tsai, Shengdar Q., Khayter, Cyd, Foden, Jennifer A., Sander, Jeffry D., Joung, J. Keith
Publicado 2012

High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets

por Kleinstiver, Benjamin P., Pattanayak, Vikram, Prew, Michelle S., Tsai, Shengdar Q., Nguyen, Nhu, Zheng, Zongli, Joung, J. Keith
Publicado 2016

CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets

por Tsai, Shengdar Q., Nguyen, Nhu T., Malagon-Lopez, Jose, Topkar, Ved V., Aryee, Martin J., Joung, J. Keith
Publicado 2017

Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity

por Guilinger, John P., Pattanayak, Vikram, Reyon, Deepak, Tsai, Shengdar Q., Sander, Jeffry D., Joung, J. Keith, Liu, David R.
Publicado 2014

Identification of SNPs and INDELS in swine transcribed sequences using short oligonucleotide microarrays

por Bischoff, Steve R, Tsai, Shengdar, Hardison, Nicholas E, York, Abby M, Freking, Brad A, Nonneman, Dan, Rohrer, Gary, Piedrahita, Jorge A
Publicado 2008

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

por Tsai, Shengdar Q., Wyvekens, Nicolas, Khayter, Cyd, Foden, Jennifer A., Thapar, Vishal, Reyon, Deepak, Goodwin, Mathew J., Aryee, Martin J., Joung, J. Keith
Publicado 2014

Differences in X-Chromosome Transcriptional Activity and Cholesterol Metabolism between Placentae from Swine Breeds from Asian and Western Origins

por Bischoff, Steve R., Tsai, Shengdar Q., Hardison, Nicholas E., Motsinger-Reif, Alison A., Freking, Bradley A., Nonneman, Dan J., Rohrer, Gary A., Piedrahita, Jorge A.
Publicado 2013

Efficient In Vivo Genome Editing Using RNA-Guided Nucleases

por Hwang, Woong Y., Fu, Yanfang, Reyon, Deepak, Maeder, Morgan L., Tsai, Shengdar Q., Sander, Jeffry D., Peterson, Randall T., Yeh, J.-R. Joanna, Joung, J. Keith
Publicado 2013

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs

por Cade, Lindsay, Reyon, Deepak, Hwang, Woong Y., Tsai, Shengdar Q., Patel, Samir, Khayter, Cyd, Joung, J. Keith, Sander, Jeffry D., Peterson, Randall T., Yeh, Jing-Ruey Joanna
Publicado 2012

Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

por Kleinstiver, Benjamin P., Tsai, Shengdar Q., Prew, Michelle S., Nguyen, Nhu T., Welch, Moira M., Lopez, Jose M., McCaw, Zachary R., Aryee, Martin J., Joung, J. Keith
Publicado 2016

Nodal patterning without Lefty inhibitory feedback is functional but fragile

por Rogers, Katherine W, Lord, Nathan D, Gagnon, James A, Pauli, Andrea, Zimmerman, Steven, Aksel, Deniz C, Reyon, Deepak, Tsai, Shengdar Q, Joung, J Keith, Schier, Alexander F
Publicado 2017

Continuous directed evolution of DNA-binding proteins to improve TALEN specificity

por Hubbard, Basil P., Badran, Ahmed H., Zuris, John A., Guilinger, John P., Davis, Kevin M., Chen, Liwei, Tsai, Shengdar Q., Sander, Jeffry D., Joung, J. Keith, Liu, David R.
Publicado 2015

GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

por Tsai, Shengdar Q., Zheng, Zongli, Nguyen, Nhu T., Liebers, Matthew, Topkar, Ved V., Thapar, Vishal, Wyvekens, Nicolas, Khayter, Cyd, Iafrate, A. John, Le, Long P., Aryee, Martin J., Joung, J. Keith
Publicado 2014

Detection of transcriptional difference of porcine imprinted genes using different microarray platforms

por Tsai, Shengdar, Mir, Bashir, Martin, Amy C, Estrada, Jose L, Bischoff, Steve R, Hsieh, Wen-ping, Cassady, Joseph P, Freking, Bradley A, Nonneman, Dan J, Rohrer, Gary A, Piedrahita, Jorge A
Publicado 2006

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

por Kleinstiver, Benjamin P., Prew, Michelle S., Tsai, Shengdar Q., Topkar, Ved, Nguyen, Nhu T., Zheng, Zongli, Gonzales, Andrew P.W., Li, Zhuyun, Peterson, Randall T., Yeh, Jing-Ruey Joanna, Aryee, Martin J., Joung, J. Keith
Publicado 2015

Targeted DNA Demethylation and Endogenous Gene Activation Using Programmable TALE-TET1 Fusions

por Maeder, Morgan L, Angstman, James F, Richardson, Marcy E, Linder, Samantha J, Cascio, Vincent M, Tsai, Shengdar Q, Ho, Quan H, Sander, Jeffry D, Reyon, Deepak, Bernstein, Bradley E, Costello, Joseph F, Wilkinson, Miles F, Joung, J Keith
Publicado 2013

Safe and efficient peripheral blood stem cell collection in patients with sickle cell disease using plerixafor

por Uchida, Naoya, Leonard, Alexis, Stroncek, David, Panch, Sandhya R., West, Kamille, Molloy, Eoghan, Hughes, Thomas E., Hauffe, Sara, Taylor, Tiffani, Fitzhugh, Courtney, Hankins, Jane S., Wilson, Megan, Sharma, Akshay, Tsai, Shengdar Q., Weiss, Mitchell J., Hsieh, Matthew, Tisdale, John F.
Publicado 2020

Base editing as a genetic treatment for spinal muscular atrophy

por Alves, Christiano R. R., Ha, Leillani L., Yaworski, Rebecca, Lazzarotto, Cicera R., Christie, Kathleen A., Reilly, Aoife, Beauvais, Ariane, Doll, Roman M., de la Cruz, Demitri, Maguire, Casey A., Swoboda, Kathryn J., Tsai, Shengdar Q., Kothary, Rashmi, Kleinstiver, Benjamin P.
Publicado 2023