Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses

por Tsakiridis, Evangelia E., Broadfield, Lindsay, Marcinko, Katarina, Biziotis, Olga-Demetra, Ali, Amr, Mekhaeil, Bassem, Ahmadi, Elham, Singh, Kanwaldeep, Mesci, Aruz, Zacharidis, Panayiotis G., Anagnostopoulos, Alexander E., Berg, Tobias, Muti, Paola, Steinberg, Gregory R., Tsakiridis, Theodoros
Publicado 2021

The SGLT2 inhibitor canagliflozin suppresses growth and enhances prostate cancer response to radiotherapy

por Ali, Amr, Mekhaeil, Bassem, Biziotis, Olga-Demetra, Tsakiridis, Evangelia E., Ahmadi, Elham, Wu, Jianhan, Wang, Simon, Singh, Kanwaldeep, Menjolian, Gabe, Farrell, Thomas, Mesci, Aruz, Liu, Stanley, Berg, Tobias, Bramson, Jonathan L., Steinberg, Gregory R., Tsakiridis, Theodoros
Publicado 2023

Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice

por Desjardins, Eric M., Wu, Jianhan, Lavoie, Declan C.T., Ahmadi, Elham, Townsend, Logan K., Morrow, Marisa R., Wang, Dongdong, Tsakiridis, Evangelia E., Batchuluun, Battsetseg, Fayyazi, Russta, Kwiecien, Jacek M., Tsakiridis, Theodoros, Lally, James S.V., Paré, Guillaume, Pinkosky, Stephen L., Steinberg, Gregory R.
Publicado 2023

The Pesticide Chlorpyrifos Promotes Obesity by Inhibiting Diet-Induced Thermogenesis

por Wang, Bo, Zhang, Shuman, Llanos, Andrea, Tsakiridis, Evangelia E, Desjardins, Eric M, Yabut, Julian M, Green, Alexander E, Day, Emily A, Smith, Brennan K, Lally, James S V, Raphenya, Amogelang R, Srinivasan, Krishna A, McArthur, Andrew G, Kajimura, Shingo, Patel, Jagdish Suresh, Wade, Michael Gordon, Morrison, Katherine Mary, Holloway, Alison, Steinberg, Gregory R
Publicado 2021

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

por Wang, Bo, Tsakiridis, Evangelia E., Zhang, Shuman, Llanos, Andrea, Desjardins, Eric M., Yabut, Julian M., Green, Alexander E., Day, Emily A., Smith, Brennan K., Lally, James S. V., Wu, Jianhan, Raphenya, Amogelang R., Srinivasan, Krishna A., McArthur, Andrew G., Kajimura, Shingo, Patel, Jagdish Suresh, Wade, Michael G., Morrison, Katherine M., Holloway, Alison C., Steinberg, Gregory R.
Publicado 2021

Metformin-induced reductions in tumor growth involves modulation of the gut microbiome()

por Broadfield, Lindsay A., Saigal, Amna, Szamosi, Jake C., Hammill, Joanne A., Bezverbnaya, Ksenia, Wang, Dongdong, Gautam, Jaya, Tsakiridis, Evangelia E., Di Pastena, Fiorella, McNicol, Jamie, Wu, Jianhan, Syed, Saad, Lally, James S.V., Raphenya, Amogelang R., Blouin, Marie-Jose, Pollak, Michael, Sacconi, Andrea, Blandino, Giovanni, McArthur, Andrew G., Schertzer, Jonathan D., Surette, Michael G., Collins, Stephen M., Bramson, Jonathan L., Muti, Paola, Tsakiridis, Theodoros, Steinberg, Gregory R.
Publicado 2022

GDF15 promotes weight loss by enhancing energy expenditure in muscle

por Wang, Dongdong, Townsend, Logan K., DesOrmeaux, Geneviève J., Frangos, Sara M., Batchuluun, Battsetseg, Dumont, Lauralyne, Kuhre, Rune Ehrenreich, Ahmadi, Elham, Hu, Sumei, Rebalka, Irena A., Gautam, Jaya, Jabile, Maria Joy Therese, Pileggi, Chantal A., Rehal, Sonia, Desjardins, Eric M., Tsakiridis, Evangelia E., Lally, James S. V., Juracic, Emma Sara, Tupling, A. Russell, Gerstein, Hertzel C., Paré, Guillaume, Tsakiridis, Theodoros, Harper, Mary-Ellen, Hawke, Thomas J., Speakman, John R., Blondin, Denis P., Holloway, Graham P., Jørgensen, Sebastian Beck, Steinberg, Gregory R.
Publicado 2023