Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches

por Iyer, Sangeetha, Mast, Joshua D., Tsang, Hillary, Rodriguez, Tamy P., DiPrimio, Nina, Prangley, Madeleine, Sam, Feba S., Parton, Zachary, Perlstein, Ethan O.
Publicado 2019

Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG

por Iyer, Sangeetha, Sam, Feba S., DiPrimio, Nina, Preston, Graeme, Verheijen, Jan, Murthy, Kausalya, Parton, Zachary, Tsang, Hillary, Lao, Jessica, Morava, Eva, Perlstein, Ethan O.
Publicado 2019

Reproducible image-based profiling with Pycytominer

por Serrano, Erik, Chandrasekaran, Srinivas Niranj, Bunten, Dave, Brewer, Kenneth I., Tomkinson, Jenna, Kern, Roshan, Bornholdt, Michael, Fleming, Stephen, Pei, Ruifan, Arevalo, John, Tsang, Hillary, Rubinetti, Vincent, Tromans-Coia, Callum, Becker, Tim, Weisbart, Erin, Bunne, Charlotte, Kalinin, Alexandr A., Senft, Rebecca, Taylor, Stephen J., Jamali, Nasim, Adeboye, Adeniyi, Abbasi, Hamdah Shafqat, Goodman, Allen, Caicedo, Juan C., Carpenter, Anne E., Cimini, Beth A., Singh, Shantanu, Way, Gregory P.
Publicado 2023