Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate

por Park, Jaeok, Lin, Yih-Shyan, Tsantrizos, Youla S., Berghuis, Albert M.
Publicado 2014

Human isoprenoid synthase enzymes as therapeutic targets

por Park, Jaeok, Matralis, Alexios N., Berghuis, Albert M., Tsantrizos, Youla S.
Publicado 2014

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

por Park, Jaeok, Zielinski, Michal, Magder, Alexandr, Tsantrizos, Youla S., Berghuis, Albert M.
Publicado 2017

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s a...

por Park, Jaeok, Lin, Yih-Shyan, De Schutter, Joris W, Tsantrizos, Youla S, Berghuis, Albert M
Publicado 2012

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase

por Park, Jaeok, Rodionov, Dmitry, De Schutter, Joris W., Lin, Yih-Shyan, Tsantrizos, Youla S., Berghuis, Albert M.
Publicado 2017