A Pipeline for Drug Target Identification and Validation

por Manchado, Eusebio, Huang, Chun-Hao, Tasdemir, Nilgun, Tschaharganeh, Darjus F., Wilkinson, John E., Lowe, Scott W.
Publicado 2017

Inducible in vivo genome editing with CRISPR/Cas9

por Dow, Lukas E, Fisher, Jonathan, O'Rourke, Kevin P, Muley, Ashlesha, Kastenhuber, Edward R, Livshits, Geulah, Tschaharganeh, Darjus F, Socci, Nicholas D, Lowe, Scott W
Publicado 2015

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

por Huang, Chun-Hao, Lujambio, Amaia, Zuber, Johannes, Tschaharganeh, Darjus F., Doran, Michael G., Evans, Michael J., Kitzing, Thomas, Zhu, Nan, de Stanchina, Elisa, Sawyers, Charles L., Armstrong, Scott A., Lewis, Jason S., Sherr, Charles J., Lowe, Scott W.
Publicado 2014

Detection of Marker-Free Precision Genome Editing and Genetic Variation through the Capture of Genomic Signatures

por Billon, Pierre, Nambiar, Tarun S., Hayward, Samuel B., Zafra, Maria P., Schatoff, Emma M., Oshima, Koichi, Dunbar, Andrew, Breinig, Marco, Park, Young C., Ryu, Han S., Tschaharganeh, Darjus F., Levine, Ross L., Baer, Richard, Ferrando, Adolfo, Dow, Lukas E., Ciccia, Alberto
Publicado 2020

Prediction of ultra-potent shRNAs with a sequential classification algorithm

por Pelossof, Raphael, Fairchild, Lauren, Huang, Chun-Hao, Widmer, Christian, Sreedharan, Vipin T., Sinha, Nishi, Lai, Dan-Yu, Guan, Yuanzhe, Premsrirut, Prem K., Tschaharganeh, Darjus F., Hoffmann, Thomas, Thapar, Vishal, Xiang, Qing, Garippa, Ralph J., Rätsch, Gunnar, Zuber, Johannes, Lowe, Scott W., Leslie, Christina S., Fellmann, Christof
Publicado 2017

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

por Zhu, Changyu, Soto-Feliciano, Yadira M, Morris, John P, Huang, Chun-Hao, Koche, Richard P, Ho, Yu-jui, Banito, Ana, Chen, Chun-Wei, Shroff, Aditya, Tian, Sha, Livshits, Geulah, Chen, Chi-Chao, Fennell, Myles, Armstrong, Scott A, Allis, C David, Tschaharganeh, Darjus F, Lowe, Scott W
Publicado 2023

Optimized base editors enable efficient editing in cells, organoids and mice

por Zafra, Maria Paz, Schatoff, Emma M, Katti, Alyna, Foronda, Miguel, Breinig, Marco, Schweitzer, Anabel Y., Simon, Amber, Han, Teng, Goswami, Sukanya, Montgomery, Emma, Thibado, Jordana, Kastenhuber, Edward R, Sánchez-Rivera, Francisco J., Shi, Junwei, Vakoc, Christopher R, Lowe, Scott W, Tschaharganeh, Darjus F., Dow, Lukas E
Publicado 2018

Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer

por Revia, Steffie, Seretny, Agnieszka, Wendler, Lena, Banito, Ana, Eckert, Christoph, Breuer, Kersten, Mayakonda, Anand, Lutsik, Pavlo, Evert, Matthias, Ribback, Silvia, Gallage, Suchira, Chikh Bakri, Ismaiel, Breuhahn, Kai, Schirmacher, Peter, Heinrich, Stefan, Gaida, Matthias M, Heikenwälder, Mathias, Calvisi, Diego F, Plass, Christoph, Lowe, Scott W, Tschaharganeh, Darjus F
Publicado 2022

Quantitative Self-Assembly Prediction Yields Targeted Nanomedicines

por Shamay, Yosi, Shah, Janki, Işık, Mehtap, Mizrachi, Aviram, Leibold, Josef, Tschaharganeh, Darjus F., Roxbury, Daniel, Budhathoki-Uprety, Januka, Nawaly, Karla, Sugarman, James L., Baut, Emily, Neiman, Michelle R., Dacek, Megan, Ganesh, Kripa S., Johnson, Darren C., Sridharan, Ramya, Chu, Karen L., Rajasekhar, Vinagolu K., Lowe, Scott W., Chodera, John D., Heller, Daniel A.
Publicado 2018

A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets

por Li, Xiang, Huang, Chun-Hao, Sánchez-Rivera, Francisco J., Kennedy, Margaret C., Tschaharganeh, Darjus F., Morris, John P., Montinaro, Antonella, O'Rourke, Kevin P., Banito, Ana, Wilkinson, John E., Chen, Chi-Chao, Ho, Yu-Jui, Dow, Lukas E., Tian, Sha, Luan, Wei, de Stanchina, Elisa, Zhang, Tinghu, Gray, Nathanael S., Walczak, Henning, Lowe, Scott W.
Publicado 2022