Bacterial topoisomerase I as a target for discovery of antibacterial compounds

por Tse-Dinh, Yuk-Ching
Publicado 2009

The role of the Zn(II) binding domain in the mechanism of E. coli DNA topoisomerase I

por Ahumada, Adriana, Tse-Dinh, Yuk-Ching
Publicado 2002

Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage

por Narula, Gagandeep, Tse-Dinh, Yuk-Ching
Publicado 2012

Mechanism of Type IA Topoisomerases

por Dasgupta, Tumpa, Ferdous, Shomita, Tse-Dinh, Yuk-Ching
Publicado 2020

Type IA Topoisomerases as Targets for Infectious Disease Treatments

por Seddek, Ahmed, Annamalai, Thirunavukkarasu, Tse-Dinh, Yuk-Ching
Publicado 2021

Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I

por Cheng, Bokun, Sorokin, Elena P., Tse-Dinh, Yuk-Ching
Publicado 2008

Resistance to topoisomerase cleavage complex induced lethality in Escherichia coli via titration of transcription regulators PurR and FNR

por Liu, I-Fen, Aedo, Sandra, Tse-Dinh, Yuk-Ching
Publicado 2011

Discovery of novel bacterial topoisomerase I inhibitors by use of in silico docking and in vitro assays

por Sandhaus, Shayna, Chapagain, Prem P., Tse-Dinh, Yuk-Ching
Publicado 2018

Direct Observation of Topoisomerase IA Gate Dynamics

por Mills, Maria, Tse-Dinh, Yuk-Ching, Neuman, Keir C.
Publicado 2018

Analysis of DNA relaxation and cleavage activities of recombinant Mycobacterium tuberculosis DNA topoisomerase I from a new expression and purification protocol

por Annamalai, Thirunavukkarasu, Dani, Neil, Cheng, Bokun, Tse-Dinh, Yuk-Ching
Publicado 2009

Microbial Type IA Topoisomerase C-Terminal Domain Sequence Motifs, Distribution and Combination

por Diaz, Brenda, Mederos, Christopher, Tan, Kemin, Tse-Dinh, Yuk-Ching
Publicado 2022

Inhibition of Zn(II) Binding Type IA Topoisomerases by Organomercury Compounds and Hg(II)

por Cheng, Bokun, Annamalai, Thirunavukkarasu, Sandhaus, Shayna, Bansod, Priyanka, Tse-Dinh, Yuk-Ching
Publicado 2015

Deacetylation of topoisomerase I is an important physiological function of E. coli CobB

por Zhou, Qingxuan, Zhou, Yan Ning, Jin, Ding Jun, Tse-Dinh, Yuk-Ching
Publicado 2017

Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site

por Cao, Nan, Tan, Kemin, Annamalai, Thirunavukkarasu, Joachimiak, Andrzej, Tse-Dinh, Yuk-Ching
Publicado 2018

Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains

por Cao, Nan, Tan, Kemin, Zuo, Xiaobing, Annamalai, Thirunavukkarasu, Tse-Dinh, Yuk-Ching
Publicado 2020

The interaction between transport-segment DNA and topoisomerase IA—crystal structure of MtbTOP1 in complex with both G- and T-segments

por Ferdous, Shomita, Dasgupta, Tumpa, Annamalai, Thirunavukkarasu, Tan, Kemin, Tse-Dinh, Yuk-Ching
Publicado 2022

Experimental and computational investigations of Ser10 and Lys13 in the binding and cleavage of DNA substrates by Escherichia coli DNA topoisomerase I

por Strahs, Daniel, Zhu, Chang-Xi, Cheng, Bokun, Chen, Jason, Tse-Dinh, Yuk-Ching
Publicado 2006

Biochemical Basis of E. coli Topoisomerase I Relaxation Activity Reduction by Nonenzymatic Lysine Acetylation

por Zhou, Qingxuan, Gomez Hernandez, Mario E., Fernandez-Lima, Francisco, Tse-Dinh, Yuk-Ching
Publicado 2018

Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I

por Tan, Kemin, Zhou, Qingxuan, Cheng, Bokun, Zhang, Zhongtao, Joachimiak, Andrzej, Tse-Dinh, Yuk-Ching
Publicado 2015

The DNA relaxation activity and covalent complex accumulation of Mycobacterium tuberculosis topoisomerase I can be assayed in Escherichia coli: application for identification of po...

por Narula, Gagandeep, Becker, Jennifer, Cheng, Bokun, Dani, Neil, Abrenica, Maria V, Tse-Dinh, Yuk-Ching
Publicado 2010