Increased Expression of EZH2 Is Mediated by Higher Glycolysis and mTORC1 Activation in Lupus CD4(+) T Cells

por Zheng, Xiaoqing, Tsou, Pei-Suen, Sawalha, Amr H.
Publicado 2020

Histone H2AX phosphorylation as a measure of DNA double-strand breaks and a marker of environmental stress and disease activity in lupus

por Namas, Rajaie, Renauer, Paul, Ognenovski, Mikhail, Tsou, Pei-Suen, Sawalha, Amr H
Publicado 2016

Blocking the janus-activated kinase pathway reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity by caspase-1 inhibition

por Marotte, Hubert, Tsou, Pei-Suen, Fedorova, Tatiana, Pinney, Adam J, Lewis, Benjamin, Koch, Alisa E
Publicado 2014

Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in scleroderma

por Tsou, Pei-Suen, Campbell, Phillip, Amin, M. Asif, Coit, Patrick, Miller, Shaylynn, Fox, David A., Khanna, Dinesh, Sawalha, Amr H.
Publicado 2019

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers

por Nagaraja, Vivek, Spino, Cathie, Bush, Erica, Tsou, Pei-Suen, Domsic, Robyn T., Lafyatis, Robert, Frech, Tracy, Gordon, Jessica K., Steen, Virginia D., Khanna, Dinesh
Publicado 2019

Deficiency of inhibitory TLR4 homolog RP105 exacerbates fibrosis

por Wang, Wenxia, Bale, Swarna, Yalavarthi, Bharath, Verma, Priyanka, Tsou, Pei-Suen, Calderone, Ken M., Bhattacharyya, Dibyendu, Fisher, Gary J., Varga, John, Bhattacharyya, Swati
Publicado 2022

Fucosyltransferase 1 mediates angiogenesis, cell adhesion and rheumatoid arthritis synovial tissue fibroblast proliferation

por Isozaki, Takeo, Ruth, Jeffrey H, Amin, Mohammad A, Campbell, Phillip L, Tsou, Pei-Suen, Ha, Christine M, Haines, G Kenneth, Edhayan, Gautam, Koch, Alisa E
Publicado 2014

Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis

por Rabquer, Bradley J, Tsou, Pei-Suen, Hou, Yong, Thirunavukkarasu, Eshwar, Haines, G Kenneth, Impens, Ann J, Phillips, Kristine, Kahaleh, Bashar, Seibold, James R, Koch, Alisa E
Publicado 2011

Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis

por Bale, Swarna, Verma, Priyanka, Yalavarthi, Bharath, Scarneo, Scott Arthur, Hughes, Philip, Amin, M. Asif, Tsou, Pei-Suen, Khanna, Dinesh, Haystead, Timothy A.J., Bhattacharyya, Swati, Varga, John
Publicado 2023

Activation of the thromboxane A2 receptor by 8-isoprostane inhibits the pro-angiogenic effect of vascular endothelial growth factor in scleroderma

por Tsou, Pei-Suen, Amin, M. Asif, Campbell, Phil, Zakhem, George, Balogh, Beatrix, Edhayan, Gautam, Ohara, Ray A., Schiopu, Elena, Khanna, Dinesh, Koch, Alisa E., Fox, David A.
Publicado 2015

Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis

por Palisoc, Pamela J., Vaikutis, Leah, Gurrea-Rubio, Mikel, Model, Ellen N., O’mara, Morgan M., Ory, Sarah, Vichaikul, Sirapa, Khanna, Dinesh, Tsou, Pei-Suen, Sawalha, Amr H.
Publicado 2022

Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts

por Tsou, Pei-Suen, Balogh, Beatrix, Pinney, Adam J, Zakhem, George, Lozier, Ann, Amin, M Asif, Stinson, William A, Schiopu, Elena, Khanna, Dinesh, Fox, David A, Koch, Alisa E
Publicado 2014

Senescent Cells Accumulate in Systemic Sclerosis Skin

por Shi, Bo, Tsou, Pei-Suen, Ma, Feiyang, Mariani, Michael P., Mattichak, Megan N., LeBrasseur, Nathan K., Chini, Eduardo N., Lafyatis, Robert, Khanna, Dinesh, Whitfield, Michael L., Gudjonsson, Johann E., Varga, John
Publicado 2023

A unique role for galectin-9 in angiogenesis and inflammatory arthritis

por O’Brien, Martin J., Shu, Qiang, Stinson, W.Alexander, Tsou, Pei-Suen, Ruth, Jeffrey H., Isozaki, Takeo, Campbell, Phillip L., Ohara, Ray A., Koch, Alisa E., Fox, David A., Amin, M. Asif
Publicado 2018

Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis

por Paul, Souren, Kaplan, Mark H., Khanna, Dinesh, McCourt, Preston M., Saha, Anjan K., Tsou, Pei-Suen, Anand, Mahek, Radecki, Alexander, Mourad, Mohamad, Sawalha, Amr H., Markovitz, David M., Contreras-Galindo, Rafael
Publicado 2022

Gut microbe-derived metabolite trimethylamine N-oxide activates PERK to drive fibrogenic mesenchymal differentiation

por Kim, Seok-Jo, Bale, Swarna, Verma, Priyanka, Wan, Qianqian, Ma, Feiyang, Gudjonsson, Johann E., Hazen, Stanley L., Harms, Paul W., Tsou, Pei-Suen, Khanna, Dinesh, Tsoi, Lam C., Gupta, Nilaksh, Ho, Karen J., Varga, John
Publicado 2022

Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide

por Shi, Hui, Gandhi, Alex A., Smith, Stephanie A., Wang, Qiuyu, Chiang, Diane, Yalavarthi, Srilakshmi, Ali, Ramadan A., Liu, Chao, Sule, Gautam, Tsou, Pei-Suen, Zuo, Yu, Kanthi, Yogendra, Farkash, Evan A., Lin, Jiandie D., Morrissey, James H., Knight, Jason S.
Publicado 2021

Pansclerotic morphea is characterized by IFN-γ responses priming dendritic cell fibroblast crosstalk to promote fibrosis

por Xing, Enze, Ma, Feiyang, Wasikowski, Rachael, Billi, Allison C., Gharaee-Kermani, Mehrnaz, Fox, Jennifer, Dobry, Craig, Victory, Amanda, Sarkar, Mrinal K., Xing, Xianying, Plazyo, Olesya, Chen, Henry W., Barber, Grant, Jacobe, Heidi, Tsou, Pei-Suen, Modlin, Robert L., Varga, John, Kahlenberg, J. Michelle, Tsoi, Lam C., Gudjonsson, Johann E., Khanna, Dinesh
Publicado 2023

Activation of Cytotoxic Lymphocytes Through CD6 Enhances Killing of Cancer Cells

por Gurrea-Rubio, Mikel, Wu, Qi, Amin, M. Asif, Tsou, Pei-Suen, Campbell, Phillip L., Amarista, Camila E., Ikari, Yuzo, Brodie, William D., Mattichak, Megan N., Muraoka, Sei, Randon, Peggy M., Lind, Matthew E., Ruth, Jeffrey H., Mao-Draayer, Yang, Ding, Shengli, Shen, Xiling, Cooney, Laura A., Lin, Feng, Fox, David A.
Publicado 2023

CD6 is a target for cancer immunotherapy

por Ruth, Jeffrey H., Gurrea-Rubio, Mikel, Athukorala, Kalana S., Rasmussen, Stephanie M., Weber, Daniel P., Randon, Peggy M., Gedert, Rosemary J., Lind, Matthew E., Amin, M. Asif, Campbell, Phillip L., Tsou, Pei-Suen, Mao-Draayer, Yang, Wu, Qi, Lanigan, Thomas M., Keshamouni, Venkateshwar G., Singer, Nora G., Lin, Feng, Fox, David A.
Publicado 2021