Microsecond molecular dynamics suggest that a non-synonymous mutation, frequently observed in patients with mild symptoms in Tokyo, alters dynamics of the SARS-CoV-2 main protea...

por Kuroda, Daisuke, Tsumoto, Kouhei
Publicado 2021

Addition of arginine hydrochloride and proline to the culture medium enhances recombinant protein expression in Brevibacillus choshinensis: The case of RBD of SARS-CoV-2 spike prot...

por Matsunaga, Ryo, Tsumoto, Kouhei
Publicado 2022

Raman Spectroscopic Analysis of Highly-Concentrated Antibodies under the Acid-Treated Conditions

por Sato, Yusui, Nagatoishi, Satoru, Noguchi, Shintaro, Tsumoto, Kouhei
Publicado 2023

Effects of Syringe Material and Silicone Oil Lubrication on the Stability of Pharmaceutical Proteins

por Krayukhina, Elena, Tsumoto, Kouhei, Uchiyama, Susumu, Fukui, Kiichi
Publicado 2015

Differential Effects of IFN-β on the Survival and Growth of Human Vascular Smooth Muscle and Endothelial Cells

por Sano, Emiko, Tashiro, Shinya, Tsumoto, Kouhei, Ueda, Takuya
Publicado 2015

Rapid Heme Transfer Reactions between NEAr Transporter Domains of Staphylococcus aureus: A Theoretical Study Using QM/MM and MD Simulations

por Moriwaki, Yoshitaka, Terada, Tohru, Tsumoto, Kouhei, Shimizu, Kentaro
Publicado 2015

Revealing the peptide presenting process of human leukocyte antigen through the analysis of fluctuation

por Yanaka, Saeko, Ueno, Takamasa, Tsumoto, Kouhei, Sugase, Kenji
Publicado 2015

Elucidation of potential sites for antibody engineering by fluctuation editing

por Yanaka, Saeko, Moriwaki, Yoshitaka, Tsumoto, Kouhei, Sugase, Kenji
Publicado 2017

Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition

por Takahashi, Tomoya, Nagatoishi, Satoru, Kuroda, Daisuke, Tsumoto, Kouhei
Publicado 2018

Discovery of chemical probes that suppress Wnt/β‐catenin signaling through high‐throughput screening

por Yamaguchi, Kiyoshi, Nagatoishi, Satoru, Tsumoto, Kouhei, Furukawa, Yoichi
Publicado 2020

Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design

por Akiba, Hiroki, Satoh, Reiko, Nagata, Satoshi, Tsumoto, Kouhei
Publicado 2019

Quantitative Laser Diffraction Method for the Assessment of Protein Subvisible Particles

por Totoki, Shinichiro, Yamamoto, Gaku, Tsumoto, Kouhei, Uchiyama, Susumu, Fukui, Kiichi
Publicado 2015

Improvement of antibody affinity by introduction of basic amino acid residues into the framework region

por Fukunaga, Atsushi, Maeta, Shingo, Reema, Bajaj, Nakakido, Makoto, Tsumoto, Kouhei
Publicado 2018

Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain V(H)H antibodies

por Ikeuchi, Emina, Kuroda, Daisuke, Nakakido, Makoto, Murakami, Akikazu, Tsumoto, Kouhei
Publicado 2021

Development of a high-throughput method to screen novel antiviral materials

por Nakakido, Makoto, Tanaka, Naoki, Shimojo, Ayako, Miyamae, Nobuhiro, Tsumoto, Kouhei
Publicado 2022

Conformational features and interaction mechanisms of V(H)H antibodies with β‐hairpin CDR3: A case of Nb8‐HigB2 interaction

por Yamamoto, Koichi, Nagatoishi, Satoru, Matsunaga, Ryo, Nakakido, Makoto, Kuroda, Daisuke, Tsumoto, Kouhei
Publicado 2023

PRDM14 directly interacts with heat shock proteins HSP90α and glucose‐regulated protein 78

por Moriya, Chiharu, Taniguchi, Hiroaki, Nagatoishi, Satoru, Igarashi, Hisayoshi, Tsumoto, Kouhei, Imai, Kohzoh
Publicado 2017

Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysis

por Chiba, Shuntaro, Tanabe, Aki, Nakakido, Makoto, Okuno, Yasushi, Tsumoto, Kouhei, Ohta, Masateru
Publicado 2020

Author Correction: Structure-based design and discovery of novel anti-tissue factor antibodies with cooperative double-point mutations, using interaction analysis

por Chiba, Shuntaro, Tanabe, Aki, Nakakido, Makoto, Okuno, Yasushi, Tsumoto, Kouhei, Ohta, Masateru
Publicado 2021

Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing

por Akiba, Hiroki, Ise, Tomoko, Nagata, Satoshi, Kamada, Haruhiko, Ohno, Hiroaki, Tsumoto, Kouhei
Publicado 2021