Transcription preinitiation complex structure and dynamics provide insight into genetic diseases

por Yan, Chunli, Dodd, Thomas, He, Yuan, Tainer, John A., Tsutakawa, Susan E., Ivanov, Ivaylo
Publicado 2019

Structural basis for recognition of 5′-phosphotyrosine adducts by TDP2

por Shi, Ke, Kurahashi, Kayo, Gao, Rui, Tsutakawa, Susan E, Tainer, John A, Pommier, Yves, Aihara, Hideki
Publicado 2012

Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases

por Yu, Jina, Yan, Chunli, Dodd, Thomas, Tsai, Chi-Lin, Tainer, John A., Tsutakawa, Susan E., Ivanov, Ivaylo
Publicado 2023

The BARD1 C-Terminal Domain Structure and Interactions with Polyadenylation Factor CstF-50

por Edwards, Ross A., Lee, Megan S., Tsutakawa, Susan E., Williams, R. Scott, Tainer, John A., Glover, J. N. Mark
Publicado 2008

Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication

por Tsutakawa, Susan E., Bacolla, Albino, Katsonis, Panagiotis, Bralić, Amer, Hamdan, Samir M., Lichtarge, Olivier, Tainer, John A., Tsai, Chi-Lin
Publicado 2021

A new structural framework for integrating replication protein A into DNA processing machinery

por Brosey, Chris A., Yan, Chunli, Tsutakawa, Susan E., Heller, William T., Rambo, Robert P., Tainer, John A., Ivanov, Ivaylo, Chazin, Walter J.
Publicado 2013

Exploring the repeat protein universe through computational protein design

por Brunette, TJ, Parmeggiani, Fabio, Huang, Po-Ssu, Bhabha, Gira, Ekiert, Damian C., Tsutakawa, Susan E., Hura, Greg L., Tainer, John A., Baker, David
Publicado 2015

Strengthening of enterococcal biofilms by Esp

por Spiegelman, Lindsey, Bahn-Suh, Adrian, Montaño, Elizabeth T., Zhang, Ling, Hura, Greg L., Patras, Kathryn A., Kumar, Amit, Tezcan, F. Akif, Nizet, Victor, Tsutakawa, Susan E., Ghosh, Partho
Publicado 2022

Dissection of DNA double-strand break repair using novel single-molecule forceps

por Wang, Jing L., Duboc, Camille, Wu, Qian, Ochi, Takashi, Liang, Shikang, Tsutakawa, Susan E., Lees-Miller, Susan P., Nadal, Marc, Tainer, John A., Blundell, Tom L., Strick, Terence R.
Publicado 2018

Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease

por Lees-Miller, James P., Cobban, Alexander, Katsonis, Panagiotis, Bacolla, Albino, Tsutakawa, Susan E., Hammel, Michal, Meek, Katheryn, Anderson, Dave W., Lichtarge, Olivier, Tainer, John A., Lees-Miller, Susan P.
Publicado 2020

A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair

por Bralić, Amer, Tehseen, Muhammad, Sobhy, Mohamed A, Tsai, Chi-Lin, Alhudhali, Lubna, Yi, Gang, Yu, Jina, Yan, Chunli, Ivanov, Ivaylo, Tsutakawa, Susan E, Tainer, John A, Hamdan, Samir M
Publicado 2022

Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1

por Rashid, Fahad, Harris, Paul D, Zaher, Manal S, Sobhy, Mohamed A, Joudeh, Luay I, Yan, Chunli, Piwonski, Hubert, Tsutakawa, Susan E, Ivanov, Ivaylo, Tainer, John A, Habuchi, Satoshi, Hamdan, Samir M
Publicado 2017

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

por Stingele, Julian, Bellelli, Roberto, Alte, Ferdinand, Hewitt, Graeme, Sarek, Grzegorz, Maslen, Sarah L., Tsutakawa, Susan E., Borg, Annabel, Kjær, Svend, Tainer, John A., Skehel, J. Mark, Groll, Michael, Boulton, Simon J.
Publicado 2016

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

por Moiani, Davide, Link, Todd M., Brosey, Chris A., Katsonis, Panagiotis, Lichtarge, Olivier, Kim, Youngchang, Joachimiak, Andrzej, Ma, Zhijun, Kim, In-Kwon, Ahmed, Zamal, Jones, Darin E., Tsutakawa, Susan E., Tainer, John A.
Publicado 2021

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication

por Wilamowski, Mateusz, Hammel, Michal, Leite, Wellington, Zhang, Qiu, Kim, Youngchang, Weiss, Kevin L., Jedrzejczak, Robert, Rosenberg, Daniel J., Fan, Yichong, Wower, Jacek, Bierma, Jan C., Sarker, Altaf H., Tsutakawa, Susan E., Pingali, Sai Venkatesh, O’Neill, Hugh M., Joachimiak, Andrzej, Hura, Greg L.
Publicado 2021

Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

por Hura, Greg L., Menon, Angeli L., Hammel, Michal, Rambo, Robert P., Poole, Farris L., Tsutakawa, Susan E., Jenney, Francis E., Classen, Scott, Frankel, Kenneth A., Hopkins, Robert C., Yang, Sung-jae, Scott, Joseph W., Dillard, Bret D., Adams, Michael W. W., Tainer, John A.
Publicado 2009

Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations

por Tsutakawa, Susan E., Sarker, Altaf H., Ng, Clifford, Arvai, Andrew S., Shin, David S., Shih, Brian, Jiang, Shuai, Thwin, Aye C., Tsai, Miaw-Sheue, Willcox, Alexandra, Her, Mai Zong, Trego, Kelly S., Raetz, Alan G., Rosenberg, Daniel, Bacolla, Albino, Hammel, Michal, Griffith, Jack D., Cooper, Priscilla K., Tainer, John A.
Publicado 2020

Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

por Tsutakawa, Susan E., Thompson, Mark J., Arvai, Andrew S., Neil, Alexander J., Shaw, Steven J., Algasaier, Sana I., Kim, Jane C., Finger, L. David, Jardine, Emma, Gotham, Victoria J.B., Sarker, Altaf H., Her, Mai Z., Rashid, Fahad, Hamdan, Samir M., Mirkin, Sergei M., Grasby, Jane A., Tainer, John A.
Publicado 2017

Corrigendum: Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

por Tsutakawa, Susan E., Thompson, Mark J., Arvai, Andrew S., Neil, Alexander J., Shaw, Steven J., Algasaier, Sana I., Kim, Jane C., Finger, L. David, Jardine, Emma, Gotham, Victoria J. B., Sarker, Altaf H., Her, Mai Z., Rashid, Fahad, Hamdan, Samir M., Mirkin, Sergei M., Grasby, Jane A., Tainer, John A.
Publicado 2017

Target highlights in CASP14: Analysis of models by structure providers

por Alexander, Leila T., Lepore, Rosalba, Kryshtafovych, Andriy, Adamopoulos, Athanassios, Alahuhta, Markus, Arvin, Ann M., Bomble, Yannick J., Böttcher, Bettina, Breyton, Cécile, Chiarini, Valerio, Chinnam, Naga babu, Chiu, Wah, Fidelis, Krzysztof, Grinter, Rhys, Gupta, Gagan D., Hartmann, Marcus D., Hayes, Christopher S., Heidebrecht, Tatjana, Ilari, Andrea, Joachimiak, Andrzej, Kim, Youngchang, Linares, Romain, Lovering, Andrew L., Lunin, Vladimir V., Lupas, Andrei N., Makbul, Cihan, Michalska, Karolina, Moult, John, Mukherjee, Prasun K., Nutt, William (Sam), Oliver, Stefan L., Perrakis, Anastassis, Stols, Lucy, Tainer, John A., Topf, Maya, Tsutakawa, Susan E., Valdivia‐Delgado, Mauricio, Schwede, Torsten
Publicado 2021