E-WE thrombin, a protein C activator, reduces disease severity and spinal cord inflammation in relapsing-remitting murine experimental autoimmune encephalomyelitis

por Verbout, Norah G, Su, Weiping, Pham, Peter, Jordan, Kelley, Kohs, Tia CL, Tucker, Erik I, McCarty, Owen JT, Sherman, Larry S
Publicado 2023

Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI

por Puy, Cristina, Tucker, Erik I., Ivanov, Ivan S., Gailani, David, Smith, Stephanie A., Morrissey, James H., Gruber, András, McCarty, Owen J. T.
Publicado 2016

Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions

por Garland, Kathleen S., Reitsma, Stéphanie E., Shirai, Toshiaki, Zilberman-Rudenko, Jevgenia, Tucker, Erik I., Gailani, David, Gruber, András, McCarty, Owen J. T., Puy, Cristina
Publicado 2017

Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation

por Parunov, Leonid A., Liang, Yideng, Lu, Qijin, Shibeko, Alexey M., Tucker, Erik I., Lee, Timothy K., Ataullakhanov, Fazoil I., Scott, Dorothy E., Ovanesov, Mikhail V.
Publicado 2023

Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice

por Bane, Charles E., Ivanov, Ivan, Matafonov, Anton, Boyd, Kelli L., Cheng, Qiufang, Sherwood, Edward R., Tucker, Erik I., Smiley, Stephen T., McCarty, Owen J. T., Gruber, Andras, Gailani, David
Publicado 2016

Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

por Wallisch, Michael, Lorentz, Christina U., Lakshmanan, Hari H. S., Johnson, Jennifer, Carris, Marschelle R., Puy, Cristina, Gailani, David, Hinds, Monica T., McCarty, Owen J. T., Gruber, András, Tucker, Erik I.
Publicado 2020

The contact activation system as a potential therapeutic target in patients with COVID‐19

por Shatzel, Joseph J., DeLoughery, Emma P., Lorentz, Christina U., Tucker, Erik I., Aslan, Joseph E., Hinds, Monica T., Gailani, David, Weitz, Jeffrey I., McCarty, Owen J. T., Gruber, Andras
Publicado 2020

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

por Silasi, Robert, Keshari, Ravi S., Regmi, Girija, Lupu, Cristina, Georgescu, Constantin, Simmons, Joe H., Wallisch, Michael, Kohs, Tia C. L., Shatzel, Joseph J., Olson, Sven R., Lorentz, Christina U., Puy, Cristina, Tucker, Erik I., Gailani, David, Strickland, Sidney, Gruber, András, McCarty, Owen J. T., Lupu, Florea
Publicado 2021