Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF

por Tunnicliffe, Richard B., Hautbergue, Guillaume M., Wilson, Stuart A., Kalra, Priti, Golovanov, Alexander P.
Publicado 2014

Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF

por Tunnicliffe, Richard B., Tian, Xiaochen, Storer, Joanna, Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Publicado 2018

Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition

por Tunnicliffe, Richard B, Levy, Colin, Ruiz Nivia, Hilda D, Sandri-Goldin, Rozanne M, Golovanov, Alexander P
Publicado 2019

The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer

por Tunnicliffe, Richard B., Schacht, Mitchell, Levy, Colin, Jowitt, Thomas A., Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Publicado 2015

The ICP27 Homology Domain of the Human Cytomegalovirus Protein UL69 Adopts a Dimer-of-Dimers Structure

por Tunnicliffe, Richard B., Collins, Richard F., Ruiz Nivia, Hilda D., Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Publicado 2018

Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold

por Zalar, Matja, Indrakumar, Sowmya, Levy, Colin W., Tunnicliffe, Richard B., Peters, Günther H. J., Golovanov, Alexander P.
Publicado 2019

Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57

por Tunnicliffe, Richard B., Hautbergue, Guillaume M., Kalra, Priti, Jackson, Brian R., Whitehouse, Adrian, Wilson, Stuart A., Golovanov, Alexander P.
Publicado 2011

Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27

por Tunnicliffe, Richard B., Hu, William K., Wu, Michele Y., Levy, Colin, Mould, A. Paul, McKenzie, Edward A., Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Publicado 2019

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

por Tunnicliffe, Richard B., Lockhart-Cairns, Michael P., Levy, Colin, Mould, A. Paul, Jowitt, Thomas A., Sito, Hilary, Baldock, Clair, Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Publicado 2017

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway

por Troilo, Helen, Barrett, Anne L., Zuk, Alexandra V., Lockhart-Cairns, Michael P., Wohl, Alexander P., Bayley, Christopher P., Dajani, Rana, Tunnicliffe, Richard B., Green, Lewis, Jowitt, Thomas A., Sengle, Gerhard, Baldock, Clair
Publicado 2016

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening app...

por Frederickson, Martyn, Selvam, Irwin R., Evangelopoulos, Dimitrios, McLean, Kirsty J., Katariya, Mona M., Tunnicliffe, Richard B., Campbell, Bethany, Kavanagh, Madeline E., Charoensutthivarakul, Sitthivut, Blankley, Richard T., Levy, Colin W., de Carvalho, Luiz Pedro S., Leys, David, Munro, Andrew W., Coyne, Anthony G., Abell, Chris
Publicado 2022