Recapitulation of cell-like KRAS4b membrane dynamics on complex biomimetic membranes

por Shrestha, Rebika, Chen, De, Frank, Peter, Nissley, Dwight V., Turbyville, Thomas J.
Publicado 2021

RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention

por Van, Que N., Prakash, Priyanka, Shrestha, Rebika, Balius, Trent E., Turbyville, Thomas J., Stephen, Andrew G.
Publicado 2021

Direct Modulators of K-Ras–Membrane Interactions

por Morstein, Johannes, Shrestha, Rebika, Van, Que N., López, César A., Arora, Neha, Tonelli, Marco, Liang, Hong, Chen, De, Zhou, Yong, Hancock, John F., Stephen, Andrew G., Turbyville, Thomas J., Shokat, Kevan M.
Publicado 2023

Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells

por Desir, Snider, Wong, Phillip, Turbyville, Thomas, Chen, De, Shetty, Mihir, Clark, Christopher, Zhai, Edward, Romin, Yevgeniy, Manova-Todorova, Katia, Starr, Timothy K., Nissley, Dwight V., Steer, Clifford J., Subramanian, Subbaya, Lou, Emil
Publicado 2019

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy

por Cuevas-Navarro, Antonio, Wagner, Morgan, Van, Richard, Swain, Monalisa, Mo, Stephanie, Columbus, John, Allison, Madeline R., Cheng, Alice, Messing, Simon, Turbyville, Thomas J., Simanshu, Dhirendra K., Sale, Matthew J., McCormick, Frank, Stephen, Andrew G., Castel, Pau
Publicado 2023

Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

por Goswami, Debanjan, Chen, De, Yang, Yue, Gudla, Prabhakar R, Columbus, John, Worthy, Karen, Rigby, Megan, Wheeler, Madeline, Mukhopadhyay, Suman, Powell, Katie, Burgan, William, Wall, Vanessa, Esposito, Dominic, Simanshu, Dhirendra K, Lightstone, Felice C, Nissley, Dwight V, McCormick, Frank, Turbyville, Thomas
Publicado 2020

Machine Learning-Driven Multiscale Modeling: Bridging the Scales with a Next-Generation Simulation Infrastructure

por Ingólfsson, Helgi I., Bhatia, Harsh, Aydin, Fikret, Oppelstrup, Tomas, López, Cesar A., Stanton, Liam G., Carpenter, Timothy S., Wong, Sergio, Di Natale, Francesco, Zhang, Xiaohua, Moon, Joseph Y., Stanley, Christopher B., Chavez, Joseph R., Nguyen, Kien, Dharuman, Gautham, Burns, Violetta, Shrestha, Rebika, Goswami, Debanjan, Gulten, Gulcin, Van, Que N., Ramanathan, Arvind, Van Essen, Brian, Hengartner, Nicolas W., Stephen, Andrew G., Turbyville, Thomas, Bremer, Peer-Timo, Gnanakaran, S., Glosli, James N., Lightstone, Felice C., Nissley, Dwight V., Streitz, Frederick H.
Publicado 2023

Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins

por Ingólfsson, Helgi I., Neale, Chris, Carpenter, Timothy S., Shrestha, Rebika, López, Cesar A., Tran, Timothy H., Oppelstrup, Tomas, Bhatia, Harsh, Stanton, Liam G., Zhang, Xiaohua, Sundram, Shiv, Di Natale, Francesco, Agarwal, Animesh, Dharuman, Gautham, Kokkila Schumacher, Sara I. L., Turbyville, Thomas, Gulten, Gulcin, Van, Que N., Goswami, Debanjan, Jean-Francois, Frantz, Agamasu, Constance, Chen, De, Hettige, Jeevapani J., Travers, Timothy, Sarkar, Sumantra, Surh, Michael P., Yang, Yue, Moody, Adam, Liu, Shusen, Van Essen, Brian C., Voter, Arthur F., Ramanathan, Arvind, Hengartner, Nicolas W., Simanshu, Dhirendra K., Stephen, Andrew G., Bremer, Peer-Timo, Gnanakaran, S., Glosli, James N., Lightstone, Felice C., McCormick, Frank, Nissley, Dwight V., Streitz, Frederick H.
Publicado 2022