A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining

por Pawelczak, Katherine S., Turchi, John J.
Publicado 2008

Chemotherapy induced DNA damage response: Convergence of drugs and pathways

por Woods, Derek, Turchi, John J.
Publicado 2013

The mechanistic role of cardiac glycosides in DNA damage response and repair signaling

por Ainembabazi, Diana, Zhang, Youwei, Turchi, John J.
Publicado 2023

Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit

por Woods, Derek S., Sears, Catherine R., Turchi, John J.
Publicado 2015

Differential activation of DNA-PK based on DNA strand orientation and sequence bias

por Pawelczak, Katherine S., Andrews, Brooke J., Turchi, John J.
Publicado 2005

Molecular analysis of Ku redox regulation

por Bennett, Sara M, Neher, Tracy M, Shatilla, Andrea, Turchi, John J
Publicado 2009

Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinase-like kinases

por Turchi, John J., Pawelczak, Katherine S., Weinfeld, Michael, McHugh, Peter J.
Publicado 2022

Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response

por Ainembabazi, Diana, Geng, Xinran, Gavande, Navnath S., Turchi, John J., Zhang, Youwei
Publicado 2022

OB-Folds and Genome Maintenance: Targeting Protein–DNA Interactions for Cancer Therapy

por Par, Sui, Vaides, Sofia, VanderVere-Carozza, Pamela S., Pawelczak, Katherine S., Stewart, Jason, Turchi, John J.
Publicado 2021

Targeting the OB-Folds of Replication Protein A with Small Molecules

por Anciano Granadillo, Victor J., Earley, Jennifer N., Shuck, Sarah C., Georgiadis, Millie M., Fitch, Richard W., Turchi, John J.
Publicado 2010

Ku–DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks

por Mendoza-Munoz, Pamela L, Gavande, Navnath S, VanderVere-Carozza, Pamela S, Pawelczak, Katherine S, Dynlacht, Joseph R, Garrett, Joy E, Turchi, John J
Publicado 2023

Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair

por Kelm, Jeremy M., Samarbakhsh, Amirreza, Pillai, Athira, VanderVere-Carozza, Pamela S., Aruri, Hariprasad, Pandey, Deepti S., Pawelczak, Katherine S., Turchi, John J., Gavande, Navnath S.
Publicado 2022

In Vivo Targeting Replication Protein A for Cancer Therapy

por VanderVere-Carozza, Pamela S., Gavande, Navnath S., Jalal, Shadia I., Pollok, Karen E., Ekinci, Elmira, Heyza, Joshua, Patrick, Steve M., Masters, Andi, Turchi, John J., Pawelczak, Katherine S.
Publicado 2022

Characterization and initial demonstration of in vivo efficacy of a novel heat-activated metalloenediyne anti-cancer agent

por Garrett, Joy, Metzger, Erin, Dewhirst, Mark W., Pollok, Karen E., Turchi, John J., Le Poole, Isabelle C., Couch, Kira, Lew, Logan, Sinn, Anthony, Zaleski, Jeffrey M., Dynlacht, Joseph R.
Publicado 2022

Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction

por Gavande, Navnath S, VanderVere-Carozza, Pamela S, Pawelczak, Katherine S, Mendoza-Munoz, Pamela, Vernon, Tyler L, Hanakahi, Leslyn A, Summerlin, Matthew, Dynlacht, Joseph R, Farmer, Annabelle H, Sears, Catherine R, Nasrallah, Nawar Al, Garrett, Joy, Turchi, John J
Publicado 2020

ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe

por Heyza, Joshua R, Ekinci, Elmira, Lindquist, Jacob, Lei, Wen, Yunker, Christopher, Vinothkumar, Vilvanathan, Rowbotham, Rachelle, Polin, Lisa, Snider, Natalie G, Van Buren, Eric, Watza, Donovan, Back, Jessica B, Chen, Wei, Mamdani, Hirva, Schwartz, Ann G, Turchi, John J, Bepler, Gerold, Patrick, Steve M
Publicado 2023