Human stem cell aging: do mitochondrial DNA mutations have a causal role?

por Baines, Holly L, Turnbull, Douglass M, Greaves, Laura C
Publicado 2014

Endocrine disorders in mitochondrial disease()

por Schaefer, Andrew M., Walker, Mark, Turnbull, Douglass M., Taylor, Robert W.
Publicado 2013

Impaired mitochondrial function abolishes gamma oscillations in the hippocampus through an effect on fast-spiking interneurons

por Whittaker, Roger G., Turnbull, Douglass M., Whittington, Miles A., Cunningham, Mark O.
Publicado 2011

The Challenges of Mitochondrial Replacement

por Chinnery, Patrick F., Craven, Lyndsey, Mitalipov, Shoukhrat, Stewart, James B., Herbert, Mary, Turnbull, Douglass M.
Publicado 2014

Assessing mitochondrial heteroplasmy using next generation sequencing: A note of caution

por Santibanez-Koref, Mauro, Griffin, Helen, Turnbull, Douglass M., Chinnery, Patrick F., Herbert, Mary, Hudson, Gavin
Publicado 2019

Concise Reviews: Assisted Reproductive Technologies to Prevent Transmission of Mitochondrial DNA Disease

por Richardson, Jessica, Irving, Laura, Hyslop, Louise A, Choudhary, Meenakshi, Murdoch, Alison, Turnbull, Douglass M, Herbert, Mary
Publicado 2015

Habitual Physical Activity in Mitochondrial Disease

por Apabhai, Shehnaz, Gorman, Grainne S., Sutton, Laura, Elson, Joanna L., Plötz, Thomas, Turnbull, Douglass M., Trenell, Michael I.
Publicado 2011

Cardiac involvement in mitochondrial DNA disease: clinical spectrum, diagnosis, and management

por Bates, Matthew G. D., Bourke, John P., Giordano, Carla, d'Amati, Giulia, Turnbull, Douglass M., Taylor, Robert W.
Publicado 2012

Perceived fatigue is highly prevalent and debilitating in patients with mitochondrial disease

por Gorman, Gráinne S., Elson, Joanna L., Newman, Jane, Payne, Brendan, McFarland, Robert, Newton, Julia L., Turnbull, Douglass M.
Publicado 2015

Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity

por Stoll, Elizabeth A., Makin, Rebecca, Sweet, Ian R., Trevelyan, Andrew J., Miwa, Satomi, Horner, Philip J., Turnbull, Douglass M.
Publicado 2015

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

por Lin, Hua, Patel, Shaan, Affleck, Valerie S., Wilson, Ian, Turnbull, Douglass M., Joshi, Abhijit R., Maxwell, Ross, Stoll, Elizabeth A.
Publicado 2017

Naked mole-rats maintain healthy skeletal muscle and Complex IV mitochondrial enzyme function into old age

por Stoll, Elizabeth A, Karapavlovic, Nevena, Rosa, Hannah, Woodmass, Michael, Rygiel, Karolina, White, Kathryn, Turnbull, Douglass M, Faulkes, Chris G
Publicado 2016

Distal weakness with respiratory insufficiency caused by the m.8344A > G “MERRF” mutation

por Blakely, Emma L., Alston, Charlotte L., Lecky, Bryan, Chakrabarti, Biswajit, Falkous, Gavin, Turnbull, Douglass M., Taylor, Robert W., Gorman, Grainne S.
Publicado 2014

Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle

por Picard, Martin, Gentil, Benoit J., McManus, Meagan J., White, Kathryn, St. Louis, Kyle, Gartside, Sarah E., Wallace, Douglas C., Turnbull, Douglass M.
Publicado 2013

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

por Baines, Holly L., Stewart, James B., Stamp, Craig, Zupanic, Anze, Kirkwood, Thomas B.L., Larsson, Nils-Göran, Turnbull, Douglass M., Greaves, Laura C.
Publicado 2014

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations

por Abramov, Andrey Y., Smulders-Srinivasan, Tora K., Kirby, Denise M., Acin-Perez, Rebeca, Enriquez, José Antonio, Lightowlers, Robert N., Duchen, Michael R., Turnbull, Douglass M.
Publicado 2010

The m.3291T>C mt-tRNA(Leu(UUR)) mutation is definitely pathogenic and causes multisystem mitochondrial disease

por Yarham, John W., Blakely, Emma L., Alston, Charlotte L., Roberts, Mark E., Ealing, John, Pal, Piyali, Turnbull, Douglass M., McFarland, Robert, Taylor, Robert W.
Publicado 2013

Discrete gait characteristics are associated with m.3243A>G and m.8344A>G variants of mitochondrial disease and its pathological consequences

por Galna, Brook, Newman, Jane, Jakovljevic, Djordje G., Bates, Matthew G., Schaefer, Andrew M., McFarland, Robert, Turnbull, Douglass M., Trenell, Michael I., Gorman, Gráinne S., Rochester, Lynn
Publicado 2013

Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants

por Pye, Deborah, Kyriakouli, Dimitra S., Taylor, Geoffrey A., Johnson, Riem, Elstner, Matthias, Meunier, Brigitte, Chrzanowska-Lightowlers, Zofia M. A., Taylor, Robert W., Turnbull, Douglass M., Lightowlers, Robert N.
Publicado 2006

Cardiomyopathy is common in patients with the mitochondrial DNA m.3243A>G mutation and correlates with mutation load

por Hollingsworth, Kieren G., Gorman, Grainne S., Trenell, Michael I., McFarland, Robert, Taylor, Robert W., Turnbull, Douglass M., MacGowan, Guy A., Blamire, Andrew M., Chinnery, Patrick F.
Publicado 2012