Uropathogenic Escherichia coli Infection Compromises the Blood-Testis Barrier by Disturbing mTORC1-mTORC2 Balance

por Lu, Yongning, Liu, Miao, Tursi, Nicholas J., Yan, Bin, Cao, Xiang, Che, Qi, Yang, Nianqin, Dong, Xi
Publicado 2021

Harnessing Recent Advances in Synthetic DNA and Electroporation Technologies for Rapid Vaccine Development Against COVID-19 and Other Emerging Infectious Diseases

por Xu, Ziyang, Patel, Ami, Tursi, Nicholas J., Zhu, Xizhou, Muthumani, Kar, Kulp, Daniel W., Weiner, David B.
Publicado 2020

In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme

por Bhojnagarwala, Pratik S., O’Connell, Ryan P., Park, Daniel, Liaw, Kevin, Ali, Ali R., Bordoloi, Devivasha, Cassel, Joel, Tursi, Nicholas J., Gary, Ebony, Weiner, David B.
Publicado 2022

Strategic Variants of CSP Delivered as SynDNA Vaccines Demonstrate Heterogeneity of Immunogenicity and Protection from Plasmodium Infection in a Murine Model

por Reeder, Sophia M., Bah, Mamadou A., Tursi, Nicholas J., Brooks, Rebekah C., Patel, Ami, Esquivel, Rianne, Eaton, Alison, Jhun, Hugo, Chu, Jacqueline, Kim, Kevin, Xu, Ziyang, Zavala, Fidel, Weiner, David B.
Publicado 2021

Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model

por Tursi, Nicholas J., Reeder, Sophia M., Flores-Garcia, Yevel, Bah, Mamadou A., Mathis-Torres, Shamika, Salgado-Jimenez, Berenice, Esquivel, Rianne, Xu, Ziyang, Chu, Jacqueline D., Humeau, Laurent, Patel, Ami, Zavala, Fidel, Weiner, David B.
Publicado 2022

Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model

por Reeder, Sophia M., Reuschel, Emma L., Bah, Mamadou A., Yun, Kun, Tursi, Nicholas J., Kim, Kevin Y., Chu, Jacqueline, Zaidi, Faraz I., Yilmaz, Ilknur, Hart, Robert J., Perrin, Benjamin, Xu, Ziyang, Humeau, Laurent, Weiner, David B., Aly, Ahmed S. I.
Publicado 2020

Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo

por Gary, Ebony N., Tursi, Nicholas J., Warner, Bryce, Parzych, Elizabeth M., Ali, Ali R., Frase, Drew, Moffat, Estella, Embury-Hyatt, Carissa, Smith, Trevor R.F., Broderick, Kate E., Humeau, Laurent, Kobasa, Darwyn, Patel, Ami, Kulp, Daniel W., Weiner, David B.
Publicado 2022

Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression in vivo

por Tursi, Nicholas J., Xu, Ziyang, Helble, Michaela, Walker, Susanne, Liaw, Kevin, Chokkalingam, Neethu, Kannan, Toshitha, Wu, Yuanhan, Tello-Ruiz, Edgar, Park, Daniel H., Zhu, Xizhou, Wise, Megan C., Smith, Trevor R. F., Majumdar, Sonali, Kossenkov, Andrew, Kulp, Daniel W., Weiner, David B.
Publicado 2023

Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge

por Gary, Ebony N., Tursi, Nicholas J., Warner, Bryce M., Cuismano, Gina, Connors, Jennifer, Parzych, Elizabeth M., Griffin, Bryan D., Bell, Matthew R., Ali, Ali R., Frase, Drew, Hojecki, Casey E., Canziani, Gabriela A., Chaiken, Irwin, Kannan, Toshitha, Moffat, Estella, Embury-Hyatt, Carissa, Wooton, Sarah K., Kossenkov, Andrew, Patel, Ami, Kobasa, Darwyn, Kutzler, Michele A., Haddad, Elias K., Weiner, David B.
Publicado 2023

Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer

por Xu, Ziyang, Walker, Susanne, Wise, Megan C., Chokkalingam, Neethu, Purwar, Mansi, Moore, Alan, Tello-Ruiz, Edgar, Wu, Yuanhan, Majumdar, Sonali, Konrath, Kylie M., Kulkarni, Abhijeet, Tursi, Nicholas J., Zaidi, Faraz I., Reuschel, Emma L., Patel, Ishaan, Obeirne, April, Du, Jianqiu, Schultheis, Katherine, Gites, Lauren, Smith, Trevor, Mendoza, Janess, Broderick, Kate E., Humeau, Laurent, Pallesen, Jesper, Weiner, David B., Kulp, Daniel W.
Publicado 2022

A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens

por Gary, Ebony N., Warner, Bryce M., Parzych, Elizabeth M., Griffin, Bryan D., Zhu, Xizhou, Tailor, Nikesh, Tursi, Nicholas J., Chan, Mable, Purwar, Mansi, Vendramelli, Robert, Choi, Jihae, Frost, Kathy L., Reeder, Sophia, Liaw, Kevin, Tello, Edgar, Ali, Ali R., Yun, Kun, Pei, Yanlong, Thomas, Sylvia P., Rghei, Amira D., Guilleman, Matthew M., Muthumani, Kar, Smith, Trevor, Wootton, Sarah K., Patel, Ami, Weiner, David B., Kobasa, Darwyn
Publicado 2021

Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection

por Konrath, Kylie M., Liaw, Kevin, Wu, Yuanhan, Zhu, Xizhou, Walker, Susanne N., Xu, Ziyang, Schultheis, Katherine, Chokkalingam, Neethu, Chawla, Himanshi, Du, Jianqiu, Tursi, Nicholas J., Moore, Alan, Adolf-Bryfogle, Jared, Purwar, Mansi, Reuschel, Emma L., Frase, Drew, Sullivan, Matthew, Fry, Benjamin, Maricic, Igor, Andrade, Viviane M., Iffland, Christel, Crispin, Max, Broderick, Kate E., Humeau, Laurent M.P.F., Patel, Ami, Smith, Trevor R.F., Pallesen, Jesper, Weiner, David B., Kulp, Daniel W.
Publicado 2022

DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2

por Parzych, Elizabeth M., Du, Jianqiu, Ali, Ali R., Schultheis, Katherine, Frase, Drew, Smith, Trevor R. F., Cui, Jiayan, Chokkalingam, Neethu, Tursi, Nicholas J., Andrade, Viviane M., Warner, Bryce M., Gary, Ebony N., Li, Yue, Choi, Jihae, Eisenhauer, Jillian, Maricic, Igor, Kulkarni, Abhijeet, Chu, Jacqueline D., Villafana, Gabrielle, Rosenthal, Kim, Ren, Kuishu, Francica, Joseph R., Wootton, Sarah K., Tebas, Pablo, Kobasa, Darwyn, Broderick, Kate E., Boyer, Jean D., Esser, Mark T., Pallesen, Jesper, Kulp, Dan W., Patel, Ami, Weiner, David B.
Publicado 2022

Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model

por Patel, Ami, Walters, Jewell N., Reuschel, Emma L., Schultheis, Katherine, Parzych, Elizabeth, Gary, Ebony N., Maricic, Igor, Purwar, Mansi, Eblimit, Zeena, Walker, Susanne N., Guimet, Diana, Bhojnagarwala, Pratik, Adeniji, Opeyemi S., Doan, Arthur, Xu, Ziyang, Elwood, Dustin, Reeder, Sophia M., Pessaint, Laurent, Kim, Kevin Y., Cook, Anthony, Chokkalingam, Neethu, Finneyfrock, Brad, Tello-Ruiz, Edgar, Dodson, Alan, Choi, Jihae, Generotti, Alison, Harrison, John, Tursi, Nicholas J., Andrade, Viviane M., Dia, Yaya, Zaidi, Faraz I., Andersen, Hanne, Abdel-Mohsen, Mohamed, Lewis, Mark G., Muthumani, Kar, Kim, J. Joseph, Kulp, Daniel W., Humeau, Laurent M., Ramos, Stephanie J., Smith, Trevor R.F., Weiner, David B., Broderick, Kate E.
Publicado 2021