Opinion: PARP inhibitors in cancer—what do we still need to know?

por Wicks, Andrew J., Krastev, Dragomir B., Pettitt, Stephen J., Tutt, Andrew N. J., Lord, Christopher J.
Publicado 2022

Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B

por Akre, Monica K., Starrett, Gabriel J., Quist, Jelmar S., Temiz, Nuri A., Carpenter, Michael A., Tutt, Andrew N. J., Grigoriadis, Anita, Harris, Reuben S.
Publicado 2016

Genomic profiling and pre-clinical modelling of breast cancer leptomeningeal metastasis reveals acquisition of a lobular-like phenotype

por Fitzpatrick, Amanda, Iravani, Marjan, Mills, Adam, Vicente, David, Alaguthurai, Thanussuyah, Roxanis, Ioannis, Turner, Nicholas C., Haider, Syed, Tutt, Andrew N. J., Isacke, Clare M.
Publicado 2023

Chondroitin Sulfate Proteoglycan 4 and Its Potential As an Antibody Immunotherapy Target across Different Tumor Types

por Ilieva, Kristina M., Cheung, Anthony, Mele, Silvia, Chiaruttini, Giulia, Crescioli, Silvia, Griffin, Merope, Nakamura, Mano, Spicer, James F., Tsoka, Sophia, Lacy, Katie E., Tutt, Andrew N. J., Karagiannis, Sophia N.
Publicado 2018

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

por Hoffmann, Ricarda M., Coumbe, Ben G. T., Josephs, Debra H., Mele, Silvia, Ilieva, Kristina M., Cheung, Anthony, Tutt, Andrew N., Spicer, James F., Thurston, David E., Crescioli, Silvia, Karagiannis, Sophia N.
Publicado 2017

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

por Bajrami, Ilirjana, Walker, Callum, Krastev, Dragomir B., Weekes, Daniel, Song, Feifei, Wicks, Andrew J., Alexander, John, Haider, Syed, Brough, Rachel, Pettitt, Stephen J., Tutt, Andrew N. J., Lord, Christopher J.
Publicado 2021

Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells

por Correa, Isabel, Ilieva, Kristina M., Crescioli, Silvia, Lombardi, Sara, Figini, Mariangela, Cheung, Anthony, Spicer, James F., Tutt, Andrew N. J., Nestle, Frank O., Karagiannis, Panagiotis, Lacy, Katie E., Karagiannis, Sophia N.
Publicado 2018

Targeting folate receptor alpha for cancer treatment

por Cheung, Anthony, Bax, Heather J., Josephs, Debra H., Ilieva, Kristina M., Pellizzari, Giulia, Opzoomer, James, Bloomfield, Jacinta, Fittall, Matthew, Grigoriadis, Anita, Figini, Mariangela, Canevari, Silvana, Spicer, James F., Tutt, Andrew N., Karagiannis, Sophia N.
Publicado 2016

Engineering and stable production of recombinant IgE for cancer immunotherapy and AllergoOncology

por Crescioli, Silvia, Chiaruttini, Giulia, Mele, Silvia, Ilieva, Kristina M., Pellizzari, Giulia, Spencer, Daniel I.R., Gardner, Richard A., Lacy, Katie E., Spicer, James F., Tutt, Andrew N.J., Wagner, Gerd K., Karagiannis, Sophia N.
Publicado 2018

Assessing CSF ctDNA to Improve Diagnostic Accuracy and Therapeutic Monitoring in Breast Cancer Leptomeningeal Metastasis

por Fitzpatrick, Amanda, Iravani, Marjan, Mills, Adam, Childs, Lucy, Alaguthurai, Thanussuyah, Clifford, Angela, Garcia-Murillas, Isaac, Van Laere, Steven, Dirix, Luc, Harries, Mark, Okines, Alicia, Turner, Nicholas C., Haider, Syed, Tutt, Andrew N.J., Isacke, Clare M.
Publicado 2022

A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant

por Pettitt, Stephen J., Shao, Nan, Zatreanu, Diana, Frankum, Jessica, Bajrami, Ilirjana, Brough, Rachel, Krastev, Dragomir B., Roumeliotis, Theodoros I., Choudhary, Jyoti S., Lorenz, Sonja, Rust, Alistair, de Bono, Johann S., Yap, Timothy A., Tutt, Andrew N. J., Lord, Christopher J.
Publicado 2023

AllergoOncology: Expression platform development and functional profiling of an anti‐HER2 IgE antibody

por Ilieva, Kristina M., Fazekas‐Singer, Judit, Bax, Heather J., Crescioli, Silvia, Montero‐Morales, Laura, Mele, Silvia, Sow, Heng Sheng, Stavraka, Chara, Josephs, Debra H., Spicer, James F., Steinkellner, Herta, Jensen‐Jarolim, Erika, Tutt, Andrew N. J., Karagiannis, Sophia N.
Publicado 2019

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

por Krastev, Dragomir B., Li, Shudong, Sun, Yilun, Wicks, Andrew J., Hoslett, Gwendoline, Weekes, Daniel, Badder, Luned M., Knight, Eleanor G., Marlow, Rebecca, Pardo, Mercedes Calvo, Yu, Lu, Talele, Tanaji T., Bartek, Jiri, Choudhary, Jyoti S., Pommier, Yves, Pettitt, Stephen J., Tutt, Andrew N. J., Ramadan, Kristijan, Lord, Christopher J.
Publicado 2022

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields

por Ilieva, Kristina M., Fazekas-Singer, Judit, Achkova, Daniela Y., Dodev, Tihomir S., Mele, Silvia, Crescioli, Silvia, Bax, Heather J., Cheung, Anthony, Karagiannis, Panagiotis, Correa, Isabel, Figini, Mariangela, Marlow, Rebecca, Josephs, Debra H., Beavil, Andrew J., Maher, John, Spicer, James F., Jensen-Jarolim, Erika, Tutt, Andrew N., Karagiannis, Sophia N.
Publicado 2017

Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

por Patel, Nirmesh, Weekes, Daniel, Drosopoulos, Konstantinos, Gazinska, Patrycja, Noel, Elodie, Rashid, Mamun, Mirza, Hasan, Quist, Jelmar, Brasó-Maristany, Fara, Mathew, Sumi, Ferro, Riccardo, Pereira, Ana Mendes, Prince, Cynthia, Noor, Farzana, Francesch-Domenech, Erika, Marlow, Rebecca, de Rinaldis, Emanuele, Grigoriadis, Anita, Linardopoulos, Spiros, Marra, Pierfrancesco, Tutt, Andrew N. J.
Publicado 2018

Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer

por Corda, Gabriele, Sala, Gianluca, Lattanzio, Rossano, Iezzi, Manuela, Sallese, Michele, Fragassi, Giorgia, Lamolinara, Alessia, Mirza, Hasan, Barcaroli, Daniela, Ermler, Sibylle, Silva, Elisabete, Yasaei, Hemad, Newbold, Robert F, Vagnarelli, Paola, Mottolese, Marcella, Natali, Pier Giorgio, Perracchio, Letizia, Quist, Jelmar, Grigoriadis, Anita, Marra, Pierfrancesco, Tutt, Andrew N, Piantelli, Mauro, Iacobelli, Stefano, De Laurenzi, Vincenzo, Sala, Arturo
Publicado 2016

Robust BRCA1‐like classification of copy number profiles of samples repeated across different datasets and platforms

por Schouten, Philip C., Grigoriadis, Anita, Kuilman, Thomas, Mirza, Hasan, Watkins, Johnathan A., Cooke, Saskia A., van Dyk, Ewald, Severson, Tesa M., Rueda, Oscar M., Hoogstraat, Marlous, Verhagen, Caroline V.M., Natrajan, Rachael, Chin, Suet-Feung, Lips, Esther H., Kruizinga, Janneke, Velds, Arno, Nieuwland, Marja, Kerkhoven, Ron M., Krijgsman, Oscar, Vens, Conchita, Peeper, Daniel, Nederlof, Petra M., Caldas, Carlos, Tutt, Andrew N., Wessels, Lodewyk F., Linn, Sabine C.
Publicado 2015

Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer

por Harris, Robert J., Cheung, Anthony, Ng, Joseph C.F., Laddach, Roman, Chenoweth, Alicia M., Crescioli, Silvia, Fittall, Matthew, Dominguez-Rodriguez, Diana, Roberts, James, Levi, Dina, Liu, Fangfang, Alberts, Elena, Quist, Jelmar, Santaolalla, Aida, Pinder, Sarah E., Gillett, Cheryl, Hammar, Niklas, Irshad, Sheeba, Van Hemelrijck, Mieke, Dunn-Walters, Deborah K., Fraternali, Franca, Spicer, James F., Lacy, Katie E., Tsoka, Sophia, Grigoriadis, Anita, Tutt, Andrew N.J., Karagiannis, Sophia N.
Publicado 2021

Niraparib for Advanced Breast Cancer with Germline BRCA1 and BRCA2 Mutations: the EORTC 1307-BCG/BIG5–13/TESARO PR-30–50–10-C BRAVO Study

por Turner, Nicholas C., Balmaña, Judith, Poncet, Coralie, Goulioti, Theodora, Tryfonidis, Konstantinos, Honkoop, Aafke H., Zoppoli, Gabriele, Razis, Evangelia, Johannsson, Oskar T., Colleoni, Marco, Tutt, Andrew N., Audeh, William, Ignatiadis, Michail, Mailliez, Audrey, Trédan, Olivier, Musolino, Antonino, Vuylsteke, Peter, Juan-Fita, Maria Jose, Macpherson, Iain R.J., Kaufman, Bella, Manso, Luis, Goldstein, Lori J., Ellard, Susan L., Láng, István, Jen, Kai Yu, Adam, Virginie, Litière, Saskia, Erban, John, Cameron, David A.
Publicado 2021

TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer

por Beatson, Richard E., Parente-Pereira, Ana C., Halim, Leena, Cozzetto, Domenico, Hull, Caroline, Whilding, Lynsey M., Martinez, Olivier, Taylor, Chelsea A., Obajdin, Jana, Luu Hoang, Kim Ngan, Draper, Benjamin, Iqbal, Ayesha, Hardiman, Tom, Zabinski, Tomasz, Man, Francis, de Rosales, Rafael T.M., Xie, Jinger, Aswad, Fred, Achkova, Daniela, Joseph, Chung-Yang Ricardo, Ciprut, Sara, Adami, Antonella, Roider, Helge G., Hess-Stumpp, Holger, Győrffy, Balázs, Quist, Jelmar, Grigoriadis, Anita, Sommer, Anette, Tutt, Andrew N.J., Davies, David M., Maher, John
Publicado 2021