AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation

por Caffrey, Brian, Zhu, Xing, Berezuk, Alison, Tuttle, Katharine, Chittori, Sagar, Subramaniam, Sriram
Publicado 2021

Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein

por Saville, James W., Mannar, Dhiraj, Zhu, Xing, Berezuk, Alison M., Cholak, Spencer, Tuttle, Katharine S., Vahdatihassani, Faezeh, Subramaniam, Sriram
Publicado 2023

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

por Mannar, Dhiraj, Saville, James W., Zhu, Xing, Srivastava, Shanti S., Berezuk, Alison M., Tuttle, Katharine S., Marquez, Ana Citlali, Sekirov, Inna, Subramaniam, Sriram
Publicado 2022

Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding

por Mannar, Dhiraj, Saville, James W., Zhu, Xing, Srivastava, Shanti S., Berezuk, Alison M., Zhou, Steven, Tuttle, Katharine S., Kim, Andrew, Li, Wei, Dimitrov, Dimiter S., Subramaniam, Sriram
Publicado 2021

Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies

por Zhu, Xing, Mannar, Dhiraj, Srivastava, Shanti S., Berezuk, Alison M., Demers, Jean-Philippe, Saville, James W., Leopold, Karoline, Li, Wei, Dimitrov, Dimiter S., Tuttle, Katharine S., Zhou, Steven, Chittori, Sagar, Subramaniam, Sriram
Publicado 2021

Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants

por Saville, James W., Mannar, Dhiraj, Zhu, Xing, Srivastava, Shanti S., Berezuk, Alison M., Demers, Jean-Philippe, Zhou, Steven, Tuttle, Katharine S., Sekirov, Inna, Kim, Andrew, Li, Wei, Dimitrov, Dimiter S., Subramaniam, Sriram
Publicado 2022

ORF Capture-Seq as a versatile method for targeted identification of full-length isoforms

por Sheynkman, Gloria M., Tuttle, Katharine S., Laval, Florent, Tseng, Elizabeth, Underwood, Jason G., Yu, Liang, Dong, Da, Smith, Melissa L., Sebra, Robert, Willems, Luc, Hao, Tong, Calderwood, Michael A., Hill, David E., Vidal, Marc
Publicado 2020

SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization

por Mannar, Dhiraj, Saville, James W., Sun, Zehua, Zhu, Xing, Marti, Michelle M., Srivastava, Shanti S., Berezuk, Alison M., Zhou, Steven, Tuttle, Katharine S., Sobolewski, Michele D., Kim, Andrew, Treat, Benjamin R., Da Silva Castanha, Priscila Mayrelle, Jacobs, Jana L., Barratt-Boyes, Simon M., Mellors, John W., Dimitrov, Dimiter S., Li, Wei, Subramaniam, Sriram
Publicado 2022