Identification of Guide-Intrinsic Determinants of Cas9 Specificity

por Huston, Nicholas C., Tycko, Josh, Tillotson, Eric L., Wilson, Christopher J., Myer, Vic E., Jayaram, Hariharan, Steinberg, Barrett E.
Publicado 2019

Modeling the efficacy of CRISPR gene drive for snail immunity on schistosomiasis control

por Grewelle, Richard E., Perez-Saez, Javier, Tycko, Josh, Namigai, Erica K. O., Rickards, Chloe G., De Leo, Giulio A.
Publicado 2022

Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells

por Tycko, Josh, Barrera, Luis A., Huston, Nicholas C., Friedland, Ari E., Wu, Xuebing, Gootenberg, Jonathan S., Abudayyeh, Omar O., Myer, Vic E., Wilson, Christopher J., Hsu, Patrick D.
Publicado 2018

Publisher Correction: Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells

por Tycko, Josh, Barrera, Luis A., Huston, Nicholas C., Friedland, Ari E., Wu, Xuebing, Gootenberg, Jonathan S., Abudayyeh, Omar O., Myer, Vic E., Wilson, Christopher J., Hsu, Patrick D.
Publicado 2018

Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome

por Durrant, Matthew G., Fanton, Alison, Tycko, Josh, Hinks, Michaela, Chandrasekaran, Sita S., Perry, Nicholas T., Schaepe, Julia, Du, Peter P., Lotfy, Peter, Bassik, Michael C., Bintu, Lacramioara, Bhatt, Ami S., Hsu, Patrick D.
Publicado 2022

CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping

por Marinov, Georgi K., Kim, Samuel H., Bagdatli, S. Tansu, Higashino, Soon Il, Trevino, Alexandro E., Tycko, Josh, Wu, Tong, Bintu, Lacramioara, Bassik, Michael C., He, Chuan, Kundaje, Anshul, Greenleaf, William J.
Publicado 2023

Gene drives for schistosomiasis transmission control

por Maier, Theresa, Wheeler, Nicolas James, Namigai, Erica K. O., Tycko, Josh, Grewelle, Richard Ernest, Woldeamanuel, Yimtubezinash, Klohe, Katharina, Perez-Saez, Javier, Sokolow, Susanne H., De Leo, Giulio A., Yoshino, Timothy P., Zamanian, Mostafa, Reinhard-Rupp, Jutta
Publicado 2019

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

por Tycko, Josh, Wainberg, Michael, Marinov, Georgi K., Ursu, Oana, Hess, Gaelen T., Ego, Braeden K., Aradhana, Li, Amy, Truong, Alisa, Trevino, Alexandro E., Spees, Kaitlyn, Yao, David, Kaplow, Irene M., Greenside, Peyton G., Morgens, David W., Phanstiel, Douglas H., Snyder, Michael P., Bintu, Lacramioara, Greenleaf, William J., Kundaje, Anshul, Bassik, Michael C.
Publicado 2019