Integrating functional genomics to accelerate mechanistic personalized medicine

por Tyner, Jeffrey W.
Publicado 2017

In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia

por Glover, Jason M, Loriaux, Marc, Tyner, Jeffrey W, Druker, Brian J, Chang, Bill H
Publicado 2012

Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent

por Leonard, Jessica T., Raess, Philipp W., Dunlap, Jennifer, Hayes-Lattin, Brandon, Tyner, Jeffrey W., Traer, Elie
Publicado 2016

Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia

por Bandyopadhyay, Shovik, Li, Junjie, Traer, Elie, Tyner, Jeffrey W., Zhou, Amy, Oh, Stephen T., Cheng, Ji-Xin
Publicado 2017

Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia

por Watanabe-Smith, Kevin, Tognon, Cristina, Tyner, Jeffrey W., Meijerink, Jules P.P., Druker, Brian J., Agarwal, Anupriya
Publicado 2016

Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients

por Rosenberg, Mara W., Watanabe-Smith, Kevin, Tyner, Jeffrey W., Tognon, Cristina E., Druker, Brian J., Borate, Uma
Publicado 2020

Immune cell proportions correlate with clinicogenomic features and ex vivo drug responses in acute myeloid leukemia

por Romine, Kyle A., Bottomly, Daniel, Yashar, William, Long, Nicola, Viehdorfer, Matthew, McWeeney, Shannon K., Tyner, Jeffrey W.
Publicado 2023

Two myeloid leukemia cases with rare FLT3 fusions

por Zhang, Haijiao, Paliga, Aleksandra, Hobbs, Evie, Moore, Stephen, Olson, Susan, Long, Nicola, Dao, Kim-Hien T., Tyner, Jeffrey W.
Publicado 2018

A molecular case report: Functional assay of tyrosine kinase inhibitors in cells from a patient’s primary renal cell carcinoma

por Kulesz-Martin, Molly, Lagowski, James, Olson, Susan, Wortham, Aaron, West, Toni, Thomas, George, Ryan, Christopher W., Tyner, Jeffrey W.
Publicado 2013

Maintenance and Pharmacologic Targeting of ROR1 Protein Levels via UHRF1 in t(1;19) pre-B-ALL

por Chow, Marilynn, Gao, Lina, MacManiman, Jason D., Bicocca, Vincent T., Chang, Bill H., Alumkal, Joshi J., Tyner, Jeffrey W.
Publicado 2018

A genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways that mediate resistance to sorafenib in acute myeloid leukemia

por Damnernsawad, Alisa, Bottomly, Daniel, Kurtz, Stephen E., Eide, Christopher A., McWeeney, Shannon K., Tyner, Jeffrey W., Nechiporuk, Tamilla
Publicado 2020

HitWalker: variant prioritization for personalized functional cancer genomics

por Bottomly, Daniel, Wilmot, Beth, Tyner, Jeffrey W., Eide, Christopher A., Loriaux, Marc M., Druker, Brian J., McWeeney, Shannon K.
Publicado 2013

Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia

por Dao, Kim-Hien T., Solti, Magdolna B., Maxson, Julia E., Winton, Elliott F., Press, Richard D., Druker, Brian J., Tyner, Jeffrey W.
Publicado 2014

Durable Disease Control with MEK Inhibition in a Patient with NRAS-mutated Atypical Chronic Myeloid Leukemia

por Khanna, Vishesh, Pierce, Scott T, Dao, Kim-Hien T, Tognon, Cristina E, Hunt, David E, Junio, Brian, Tyner, Jeffrey W, Druker, Brian J
Publicado 2015

Ultrasensitive proteomic quantitation of cellular signaling by digitized nanoparticle-protein counting

por Jacob, Thomas, Agarwal, Anupriya, Ramunno-Johnson, Damien, O’Hare, Thomas, Gönen, Mehmet, Tyner, Jeffrey W., Druker, Brian J., Vu, Tania Q.
Publicado 2016

Growth Arrest of BCR-ABL Positive Cells with a Sequence-Specific Polyamide-Chlorambucil Conjugate

por Chou, C. James, O'Hare, Thomas, Lefebvre, Sophie, Alvarez, David, Tyner, Jeffrey W., Eide, Christopher A., Druker, Brian J., Gottesfeld, Joel M.
Publicado 2008

Belinostat and panobinostat (HDACI): in vitro and in vivo studies in thyroid cancer

por Chan, Daniel, Zheng, Yun, Tyner, Jeffrey W., Chng, Wee Joo, Chien, Wen Wen, Gery, Sigal, Leong, Geraldine, Braunstein, Glenn D., Koeffler, H. Phillip
Publicado 2013

Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine

por Bottomly, Daniel, Ryabinin, Peter A, Tyner, Jeffrey W, Chang, Bill H, Loriaux, Marc M, Druker, Brian J, McWeeney, Shannon K, Wilmot, Beth
Publicado 2013

Small molecule inhibitor screen identifies synergistic activity of the bromodomain inhibitor CPI203 and bortezomib in drug resistant myeloma

por Siegel, Matthew B., Liu, Selina Qiuying, Davare, Monika A., Spurgeon, Stephen E., Loriaux, Marc M., Druker, Brian J., Scott, Emma C., Tyner, Jeffrey W.
Publicado 2015

Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations

por Zhang, Haijiao, Schultz, Anna Reister, Luty, Samuel, Rofelty, Angela, Su, Yulong, Means, Sophie, Bottomly, Daniel, Wilmot, Beth, McWeeney, Shannon K., Tyner, Jeffrey W.
Publicado 2017