Intrinsic Viral Factors Are the Dominant Determinants of the Hepatitis C Virus Response to Interferon Alpha Treatment in Chimeric Mice

por Chen, Ran, Kobewka, Michelle, Addison, William, Lachance, Gerald, Tyrrell, D. Lorne
Publicado 2016

The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections

por Egli, Adrian, Santer, Deanna M, O'Shea, Daire, Tyrrell, D Lorne, Houghton, Michael
Publicado 2014

Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on Erythropoiesis

por Saito, Suguru, Shahbaz, Shima, Sligl, Wendy, Osman, Mohammed, Tyrrell, D. Lorne, Elahi, Shokrollah
Publicado 2022

Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism

por Sarhan, Mohammed A., Abdel-Hakeem, Mohamed S., Mason, Andrew L., Tyrrell, D. Lorne, Houghton, Michael
Publicado 2017

Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles

por Shahbaz, Shima, Bozorgmehr, Najmeh, Lu, Julia, Osman, Mohammed, Sligl, Wendy, Tyrrell, D. Lorne, Elahi, Shokrollah
Publicado 2023

In Vitro Infection with Hepatitis B Virus Using Differentiated Human Serum Culture of Huh7.5-NTCP Cells without Requiring Dimethyl Sulfoxide

por Le, Connie, Sirajee, Reshma, Steenbergen, Rineke, Joyce, Michael A., Addison, William R., Tyrrell, D. Lorne
Publicado 2021

Enhanced Activation of Memory, but Not Naïve, B Cells in Chronic Hepatitis C Virus-Infected Patients with Cryoglobulinemia and Advanced Liver Fibrosis

por Santer, Deanna M., Ma, Mang M., Hockman, Darren, Landi, Abdolamir, Tyrrell, D. Lorne J., Houghton, Michael
Publicado 2013

Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2

por Shahbaz, Shima, Xu, Lai, Osman, Mohammed, Sligl, Wendy, Shields, Justin, Joyce, Michael, Tyrrell, D. Lorne, Oyegbami, Olaide, Elahi, Shokrollah
Publicado 2021

Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19

por Aminpour, Maral, Delgado, Williams Ernesto Miranda, Wacker, Soren, Noskov, Sergey, Houghton, Michael, Tyrrell, D. Lorne J., Tuszynski, Jack A.
Publicado 2021

Multiplex Assays Enable Simultaneous Detection and Identification of SARS-CoV-2 Variants of Concern in Clinical and Wastewater Samples

por Liu, Yanming, Kumblathan, Teresa, Joyce, Michael A., Tyrrell, D. Lorne, Tipples, Graham, Pang, Xiaoli, Li, Xing-Fang, Le, X. Chris
Publicado 2023

Therapeutic Efficacy of Human Hepatocyte Transplantation in a SCID/uPA Mouse Model with Inducible Liver Disease

por Douglas, Donna N., Kawahara, Toshiyasu, Sis, Banu, Bond, David, Fischer, Karl P., Tyrrell, D. Lorne J., Lewis, Jamie T., Kneteman, Norman M.
Publicado 2010

HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response

por Joyce, Michael A., Berry-Wynne, Karyn M., dos Santos, Theodore, Addison, William R., McFarlane, Nicola, Hobman, Tom, Tyrrell, D. Lorne
Publicado 2019

Hepatitis C Virus-Induced Cytoplasmic Organelles Use the Nuclear Transport Machinery to Establish an Environment Conducive to Virus Replication

por Neufeldt, Christopher J., Joyce, Michael A., Levin, Aviad, Steenbergen, Rineke H., Pang, Daniel, Shields, Justin, Tyrrell, D. Lorne J., Wozniak, Richard W.
Publicado 2013

Functional Characterization of Nuclear Localization and Export Signals in Hepatitis C Virus Proteins and Their Role in the Membranous Web

por Levin, Aviad, Neufeldt, Christopher J., Pang, Daniel, Wilson, Kristen, Loewen-Dobler, Darci, Joyce, Michael A., Wozniak, Richard W., Tyrrell, D. Lorne J
Publicado 2014

IFITM1 is a tight junction protein that inhibits hepatitis C virus entry,

por Wilkins, Courtney, Woodward, Jessica, Lau, Daryl T.‐Y., Barnes, Amy, Joyce, Michael, McFarlane, Nicola, McKeating, Jane A., Tyrrell, D. Lorne, Gale, Michael
Publicado 2013

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites

por Neufeldt, Christopher J., Joyce, Michael A., Van Buuren, Nicholas, Levin, Aviad, Kirkegaard, Karla, Gale Jr., Michael, Tyrrell, D. Lorne J., Wozniak, Richard W.
Publicado 2016

Application of functional genomics to the chimeric mouse model of HCV infection: optimization of microarray protocols and genomics analysis

por Walters, Kathie-Anne, Joyce, Michael A, Thompson, Jill C, Proll, Sean, Wallace, James, Smith, Maria W, Furlong, Jeff, Tyrrell, D Lorne, Katze, Michael G
Publicado 2006

Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection

por Duncan, Joseph K. Sampson, Xu, Danyang, Licursi, Maria, Joyce, Michael A., Saffran, Holly A., Liu, Kaiwen, Gohda, Jin, Tyrrell, D. Lorne, Kawaguchi, Yasushi, Hirasawa, Kensuke
Publicado 2023

HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice

por Joyce, Michael A., Walters, Kathie-Anne, Lamb, Sue-Ellen, Yeh, Mathew M., Zhu, Lin-Fu, Kneteman, Norman, Doyle, Jason S., Katze, Michael G., Tyrrell, D. Lorne
Publicado 2009

Interferon-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity

por Santer, Deanna M., Li, Daniel, Ghosheh, Yanal, Zahoor, Muhammad Atif, Prajapati, Dhanvi, Hansen, Bettina E., Tyrrell, D. Lorne J., Feld, Jordan J., Gehring, Adam J.
Publicado 2022