Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS

por Tyzack, Giulia E, Manferrari, Giulia, Newcombe, Jia, Luscombe, Nicholas M, Luisier, Raphaelle, Patani, Rickie
Publicado 2020

Automated and unbiased discrimination of ALS from control tissue at single cell resolution

por Hagemann, Cathleen, Tyzack, Giulia E., Taha, Doaa M., Devine, Helen, Greensmith, Linda, Newcombe, Jia, Patani, Rickie, Serio, Andrea, Luisier, Raphaëlle
Publicado 2021

Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis

por Petrić Howe, Marija, Crerar, Hamish, Neeves, Jacob, Harley, Jasmine, Tyzack, Giulia E., Klein, Pierre, Ramos, Andres, Patani, Rickie, Luisier, Raphaëlle
Publicado 2022

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis

por Tyzack, Giulia E, Neeves, Jacob, Crerar, Hamish, Klein, Pierre, Ziff, Oliver, Taha, Doaa M, Luisier, Raphaëlle, Luscombe, Nicholas M, Patani, Rickie
Publicado 2021

Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis

por Smethurst, Phillip, Risse, Emmanuel, Tyzack, Giulia E, Mitchell, Jamie S, Taha, Doaa M, Chen, Yun-Ru, Newcombe, Jia, Collinge, John, Sidle, Katie, Patani, Rickie
Publicado 2020

The FUS gene is dual‐coding with both proteins contributing to FUS‐mediated toxicity

por Brunet, Marie A, Jacques, Jean‐Francois, Nassari, Sonya, Tyzack, Giulia E, McGoldrick, Philip, Zinman, Lorne, Jean, Steve, Robertson, Janice, Patani, Rickie, Roucou, Xavier
Publicado 2020

Reactive astrocytes in ALS display diminished intron retention

por Ziff, Oliver J, Taha, Doaa M, Crerar, Hamish, Clarke, Benjamin E, Chakrabarti, Anob M, Kelly, Gavin, Neeves, Jacob, Tyzack, Giulia E, Luscombe, Nicholas M, Patani, Rickie
Publicado 2021

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis

por Tyzack, Giulia E, Luisier, Raphaelle, Taha, Doaa M, Neeves, Jacob, Modic, Miha, Mitchell, Jamie S, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M, Patani, Rickie
Publicado 2019

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

por Tyzack, Giulia E., Sitnikov, Sergey, Barson, Daniel, Adams-Carr, Kerala L., Lau, Nike K., Kwok, Jessica C., Zhao, Chao, Franklin, Robin J. M., Karadottir, Ragnhildur T., Fawcett, James W., Lakatos, András
Publicado 2014

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

por Luisier, Raphaelle, Tyzack, Giulia E., Hall, Claire E., Mitchell, Jamie S., Devine, Helen, Taha, Doaa M., Malik, Bilal, Meyer, Ione, Greensmith, Linda, Newcombe, Jia, Ule, Jernej, Luscombe, Nicholas M., Patani, Rickie
Publicado 2018

Delineating Astrocytic Cytokine Responses in a Human Stem Cell Model of Neural Trauma

por Thelin, Eric Peter, Hall, Claire E., Tyzack, Giulia E., Frostell, Arvid, Giorgi-Coll, Susan, Alam, Aftab, Carpenter, Keri L.H., Mitchell, Jamie, Tajsic, Tamara, Hutchinson, Peter J., Patani, Rickie, Helmy, Adel
Publicado 2020

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

por Tyzack, Giulia E., Hall, Claire E., Sibley, Christopher R., Cymes, Tomasz, Forostyak, Serhiy, Carlino, Giulia, Meyer, Ione F., Schiavo, Giampietro, Zhang, Su-Chun, Gibbons, George M., Newcombe, Jia, Patani, Rickie, Lakatos, András
Publicado 2017

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis

por Taha, Doaa M, Clarke, Benjamin E, Hall, Claire E, Tyzack, Giulia E, Ziff, Oliver J, Greensmith, Linda, Kalmar, Bernadett, Ahmed, Mhoriam, Alam, Aftab, Thelin, Eric P, Garcia, Nuria Marco, Helmy, Adel, Sibley, Christopher R, Patani, Rickie
Publicado 2022

Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength

por Kelley, Kevin W., Ben Haim, Lucile, Schirmer, Lucas, Tyzack, Giulia E., Tolman, Michaela, Miller, John G., Tsai, Hui-Hsin, Chang, Sandra M., Molofsky, Anna V., Yang, Yongjie, Patani, Rickie, Lakatos, Andras, Ullian, Erik M., Rowitch, David H.
Publicado 2018

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering

por Maffioletti, Sara Martina, Sarcar, Shilpita, Henderson, Alexander B.H., Mannhardt, Ingra, Pinton, Luca, Moyle, Louise Anne, Steele-Stallard, Heather, Cappellari, Ornella, Wells, Kim E., Ferrari, Giulia, Mitchell, Jamie S., Tyzack, Giulia E., Kotiadis, Vassilios N., Khedr, Moustafa, Ragazzi, Martina, Wang, Weixin, Duchen, Michael R., Patani, Rickie, Zammit, Peter S., Wells, Dominic J., Eschenhagen, Thomas, Tedesco, Francesco Saverio
Publicado 2018

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

por Hall, Claire E., Yao, Zhi, Choi, Minee, Tyzack, Giulia E., Serio, Andrea, Luisier, Raphaelle, Harley, Jasmine, Preza, Elisavet, Arber, Charlie, Crisp, Sarah J., Watson, P. Marc D., Kullmann, Dimitri M., Abramov, Andrey Y., Wray, Selina, Burley, Russell, Loh, Samantha H.Y., Martins, L. Miguel, Stevens, Molly M., Luscombe, Nicholas M., Sibley, Christopher R., Lakatos, Andras, Ule, Jernej, Gandhi, Sonia, Patani, Rickie
Publicado 2017