Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells

por YAMAMOTO, TETSUSHI, UEMURA, KENTARO, MORIYAMA, KAHO, MITAMURA, KUNIKO, TAGA, ATSUSHI
Publicado 2015

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

por Sasaki, Michihito, Uemura, Kentaro, Sato, Akihiko, Toba, Shinsuke, Sanaki, Takao, Maenaka, Katsumi, Hall, William W., Orba, Yasuko, Sawa, Hirofumi
Publicado 2021

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein

por Kishimoto, Mai, Uemura, Kentaro, Sanaki, Takao, Sato, Akihiko, Hall, William W., Kariwa, Hiroaki, Orba, Yasuko, Sawa, Hirofumi, Sasaki, Michihito
Publicado 2021

MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2

por Uemura, Kentaro, Sasaki, Michihito, Sanaki, Takao, Toba, Shinsuke, Takahashi, Yoshimasa, Orba, Yasuko, Hall, William W., Maenaka, Katsumi, Sawa, Hirofumi, Sato, Akihiko
Publicado 2021

Host Serine Proteases TMPRSS2 and TMPRSS11D Mediate Proteolytic Activation and Trypsin-Independent Infection in Group A Rotaviruses

por Sasaki, Michihito, Itakura, Yukari, Kishimoto, Mai, Tabata, Koshiro, Uemura, Kentaro, Ito, Naoto, Sugiyama, Makoto, Wastika, Christida E., Orba, Yasuko, Sawa, Hirofumi
Publicado 2021

Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells

por Sasaki, Michihito, Kishimoto, Mai, Itakura, Yukari, Tabata, Koshiro, Intaruck, Kittiya, Uemura, Kentaro, Toba, Shinsuke, Sanaki, Takao, Sato, Akihiko, Hall, William W., Orba, Yasuko, Sawa, Hirofumi
Publicado 2021

Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9

por Kurihara, Takeshi, Fukuhara, Takasuke, Ono, Chikako, Yamamoto, Satomi, Uemura, Kentaro, Okamoto, Toru, Sugiyama, Masaya, Motooka, Daisuke, Nakamura, Shota, Ikawa, Masato, Mizokami, Masashi, Maehara, Yoshihiko, Matsuura, Yoshiharu
Publicado 2017

SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity

por Sasaki, Michihito, Toba, Shinsuke, Itakura, Yukari, Chambaro, Herman M., Kishimoto, Mai, Tabata, Koshiro, Intaruck, Kittiya, Uemura, Kentaro, Sanaki, Takao, Sato, Akihiko, Hall, William W., Orba, Yasuko, Sawa, Hirofumi
Publicado 2021

Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus

por Yamamoto, Satomi, Fukuhara, Takasuke, Ono, Chikako, Uemura, Kentaro, Kawachi, Yukako, Shiokawa, Mai, Mori, Hiroyuki, Wada, Masami, Shima, Ryoichi, Okamoto, Toru, Hiraga, Nobuhiko, Suzuki, Ryosuke, Chayama, Kazuaki, Wakita, Takaji, Matsuura, Yoshiharu
Publicado 2016

Host-derived apolipoproteins play comparable roles with viral secretory proteins E(rns) and NS1 in the infectious particle formation of Flaviviridae

por Fukuhara, Takasuke, Tamura, Tomokazu, Ono, Chikako, Shiokawa, Mai, Mori, Hiroyuki, Uemura, Kentaro, Yamamoto, Satomi, Kurihara, Takeshi, Okamoto, Toru, Suzuki, Ryosuke, Yoshii, Kentaro, Kurosu, Takeshi, Igarashi, Manabu, Aoki, Hiroshi, Sakoda, Yoshihiro, Matsuura, Yoshiharu
Publicado 2017

5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2

por Uemura, Kentaro, Nobori, Haruaki, Sato, Akihiko, Sanaki, Takao, Toba, Shinsuke, Sasaki, Michihito, Murai, Akiho, Saito-Tarashima, Noriko, Minakawa, Noriaki, Orba, Yasuko, Kariwa, Hiroaki, Hall, William W., Sawa, Hirofumi, Matsuda, Akira, Maenaka, Katsumi
Publicado 2021

Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation

por Dianty, Rahmi, Hirano, Junki, Anzai, Itsuki, Kanai, Yuta, Hayashi, Tsuyoshi, Morimoto, Masae, Kataoka-Nakamura, Chikako, Kobayashi, Sakura, Uemura, Kentaro, Ono, Chikako, Watanabe, Tokiko, Kobayashi, Takeshi, Murakami, Kosuke, Kikuchi, Kenji, Hotta, Kunimoto, Yoshikawa, Toshikazu, Taguwa, Shuhei, Matsuura, Yoshiharu
Publicado 2023

An African tick flavivirus forming an independent clade exhibits unique exoribonuclease-resistant RNA structures in the genomic 3′-untranslated region

por Harima, Hayato, Orba, Yasuko, Torii, Shiho, Qiu, Yongjin, Kajihara, Masahiro, Eto, Yoshiki, Matsuta, Naoya, Hang’ombe, Bernard M., Eshita, Yuki, Uemura, Kentaro, Matsuno, Keita, Sasaki, Michihito, Yoshii, Kentaro, Nakao, Ryo, Hall, William W., Takada, Ayato, Abe, Takashi, Wolfinger, Michael T., Simuunza, Martin, Sawa, Hirofumi
Publicado 2021

2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses

por Uemura, Kentaro, Nobori, Haruaki, Sato, Akihiko, Toba, Shinsuke, Kusakabe, Shinji, Sasaki, Michihito, Tabata, Koshiro, Matsuno, Keita, Maeda, Naoyoshi, Ito, Shiori, Tanaka, Mayu, Anraku, Yuki, Kita, Shunsuke, Ishii , Mayumi, Kanamitsu, Kayoko, Orba, Yasuko, Matsuura, Yoshiharu, Hall, William W., Sawa, Hirofumi, Kida, Hiroshi, Matsuda, Akira, Maenaka, Katsumi
Publicado 2023

Characterization of miR-122-independent propagation of HCV

por Ono, Chikako, Fukuhara, Takasuke, Motooka, Daisuke, Nakamura, Shota, Okuzaki, Daisuke, Yamamoto, Satomi, Tamura, Tomokazu, Mori, Hiroyuki, Sato, Asuka, Uemura, Kentaro, Fauzyah, Yuzy, Kurihara, Takeshi, Suda, Takahiro, Nishio, Akira, Hmwe, Su Su, Okamoto, Toru, Tatsumi, Tomohide, Takehara, Tetsuo, Chayama, Kazuaki, Wakita, Takaji, Koike, Kazuhiko, Matsuura, Yoshiharu
Publicado 2017

S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters

por Sasaki, Michihito, Tabata, Koshiro, Kishimoto, Mai, Itakura, Yukari, Kobayashi, Hiroko, Ariizumi, Takuma, Uemura, Kentaro, Toba, Shinsuke, Kusakabe, Shinji, Maruyama, Yuki, Iida, Shun, Nakajima, Noriko, Suzuki, Tadaki, Yoshida, Shinpei, Nobori, Haruaki, Sanaki, Takao, Kato, Teruhisa, Shishido, Takao, Hall, William W., Orba, Yasuko, Sato, Akihiko, Sawa, Hirofumi
Publicado 2022

Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

por Unoh, Yuto, Uehara, Shota, Nakahara, Kenji, Nobori, Haruaki, Yamatsu, Yukiko, Yamamoto, Shiho, Maruyama, Yuki, Taoda, Yoshiyuki, Kasamatsu, Koji, Suto, Takahiro, Kouki, Kensuke, Nakahashi, Atsufumi, Kawashima, Sho, Sanaki, Takao, Toba, Shinsuke, Uemura, Kentaro, Mizutare, Tohru, Ando, Shigeru, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Sato, Akihiko, Sato, Takafumi, Kato, Teruhisa, Tachibana, Yuki
Publicado 2022

Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses

por Toba, Shinsuke, Sato, Akihiko, Kawai, Makoto, Taoda, Yoshiyuki, Unoh, Yuto, Kusakabe, Shinji, Nobori, Haruaki, Uehara, Shota, Uemura, Kentaro, Taniguchi, Keiichi, Kobayashi, Masanori, Noshi, Takeshi, Yoshida, Ryu, Naito, Akira, Shishido, Takao, Maruyama, Junki, Paessler, Slobodan, Carr, Michael J., Hall, William W., Yoshimatsu, Kumiko, Arikawa, Jiro, Matsuno, Keita, Sakoda, Yoshihiro, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Kida, Hiroshi
Publicado 2022