Comparative Nephrotoxicity of Cisplatin and Nedaplatin: Mechanisms and Histopathological Characteristics

por Uehara, Takeki, Yamate, Jyoji, Torii, Mikinori, Maruyama, Toshiyuki
Publicado 2011

Cap-dependent Endonuclease Inhibitor S-033188 for the Treatment of Influenza: Results from a Phase 3, Randomized, Double-Blind, Placebo- and Active-Controlled Study in Otherwise He...

por Portsmouth, Simon, Kawaguchi, Keiko, Arai, Masatsugu, Tsuchiya, Kenji, Uehara, Takeki
Publicado 2017

1645. Exploring Clinical and Antiviral Efficacy of Baloxavir Marboxil in a Phase 3, Randomized, Double-Blind, Placebo- and Active-Controlled Study of Otherwise Healthy Adults/Adole...

por Kawaguchi, Keiko, Portsmouth, Simon, Shishido, Takao, Uehara, Takeki, Hayden, Frederick
Publicado 2018

Characterization of copy number alterations in a mouse model of fibrosis‐associated hepatocellular carcinoma reveals concordance with human disease

por Chappell, Grace, Silva, Grace O., Uehara, Takeki, Pogribny, Igor P., Rusyn, Ivan
Publicado 2016

LB16. Phase 3 Trial of Baloxavir Marboxil in High-Risk Influenza Patients (CAPSTONE-2 Study)

por Ison, Michael G, Portsmouth, Simon, Yoshida, Yuki, Shishido, Takao, Hayden, Frederick, Uehara, Takeki
Publicado 2018

Combinatorial Measurement of CDKN1A/p21 and KIF20A Expression for Discrimination of DNA Damage-Induced Clastogenicity

por Sakai, Rina, Morikawa, Yuji, Kondo, Chiaki, Oka, Hiroyuki, Miyajima, Hirofumi, Kubo, Kihei, Uehara, Takeki
Publicado 2014

Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study

por Harding, Joanne, Bernasconi, Corrado, Williams, Sarah, Wildum, Steffen, Kinoshita, Masahiro, Uehara, Takeki, Hurt, Aeron C.
Publicado 2023

Baloxavir safety and clinical and virologic outcomes in influenza virus-infected pediatric patients by age group: age-based pooled analysis of two pediatric studies conducted in Ja...

por Hirotsu, Nobuo, Sakaguchi, Hiroki, Fukao, Keita, Kojima, Satoshi, Piedra, Pedro A., Tsuchiya, Kenji, Uehara, Takeki
Publicado 2023

Baloxavir Marboxil 2% Granules in Japanese Children With Influenza: An Open-label Phase 3 Study

por Yokoyama, Takato, Sakaguchi, Hiroki, Ishibashi, Toru, Shishido, Takao, Piedra, Pedro A., Sato, Chisako, Tsuchiya, Kenji, Uehara, Takeki
Publicado 2020

Baloxavir Treatment in Adolescents With Acute Influenza: Subgroup Analysis From the CAPSTONE-1 Trial

por Portsmouth, Simon, Hayden, Frederick G, Kawaguchi, Keiko, Ishibashi, Toru, Kinoshita, Masahiro, Shishido, Takao, Tsuchiya, Kenji, Uehara, Takeki
Publicado 2020

miRNA expression atlas in male rat

por Minami, Keiichi, Uehara, Takeki, Morikawa, Yuji, Omura, Ko, Kanki, Masayuki, Horinouchi, Akira, Ono, Atsushi, Yamada, Hiroshi, Ohno, Yasuo, Urushidani, Tetsuro
Publicado 2014

Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus

por Baba, Keiko, Oka, Ryoko, Shano, Shinya, Omoto, Shinya, Noshi, Takeshi, Shishido, Takao, Naito, Akira, Kawaguchi, Keiko, Ishibashi, Toru, Uehara, Takeki
Publicado 2020

A phase 2/3 study of S-217622 in participants with SARS-CoV-2 infection (Phase 3 part)

por Yotsuyanagi, Hiroshi, Ohmagari, Norio, Doi, Yohei, Imamura, Takumi, Sonoyama, Takuhiro, Ichihashi, Genki, Sanaki, Takao, Tsuge, Yuko, Uehara, Takeki, Mukae, Hiroshi
Publicado 2023

Efficacy and Safety of Ensitrelvir in Patients With Mild-to-Moderate Coronavirus Disease 2019: The Phase 2b Part of a Randomized, Placebo-Controlled, Phase 2/3 Study

por Mukae, Hiroshi, Yotsuyanagi, Hiroshi, Ohmagari, Norio, Doi, Yohei, Sakaguchi, Hiroki, Sonoyama, Takuhiro, Ichihashi, Genki, Sanaki, Takao, Baba, Keiko, Tsuge, Yuko, Uehara, Takeki
Publicado 2022

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil

por Omoto, Shinya, Speranzini, Valentina, Hashimoto, Takashi, Noshi, Takeshi, Yamaguchi, Hiroto, Kawai, Makoto, Kawaguchi, Keiko, Uehara, Takeki, Shishido, Takao, Naito, Akira, Cusack, Stephen
Publicado 2018

Baloxavir Marboxil in Japanese Pediatric Patients With Influenza: Safety and Clinical and Virologic Outcomes

por Hirotsu, Nobuo, Sakaguchi, Hiroki, Sato, Chisako, Ishibashi, Toru, Baba, Keiko, Omoto, Shinya, Shishido, Takao, Tsuchiya, Kenji, Hayden, Frederick G, Uehara, Takeki, Watanabe, Akira
Publicado 2020

A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infe...

por Mukae, Hiroshi, Yotsuyanagi, Hiroshi, Ohmagari, Norio, Doi, Yohei, Imamura, Takumi, Sonoyama, Takuhiro, Fukuhara, Takahiro, Ichihashi, Genki, Sanaki, Takao, Baba, Keiko, Takeda, Yosuke, Tsuge, Yuko, Uehara, Takeki
Publicado 2022

Mechanistic roles of microRNAs in hepatocarcinogenesis: A study of thioacetamide with multiple doses and time-points of rats

por Dweep, Harsh, Morikawa, Yuji, Gong, Binsheng, Yan, Jian, Liu, Zhichao, Chen, Tao, Bisgin, Halil, Zou, Wen, Hong, Huixiao, Shi, Tieliu, Gong, Ping, Castro, Christina, Uehara, Takeki, Wang, Yuping, Tong, Weida
Publicado 2017

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

por Lee, Leo Y, Zhou, Jie, Koszalka, Paulina, Frise, Rebecca, Farrukee, Rubaiyea, Baba, Keiko, Miah, Shahjahan, Shishido, Takao, Galiano, Monica, Hashimoto, Takashi, Omoto, Shinya, Uehara, Takeki, Mifsud, Edin J., Collinson, Neil, Kuhlbusch, Klaus, Clinch, Barry, Wildum, Steffen, Barclay, Wendy S., Hurt, Aeron C.
Publicado 2021

Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission

por Lee, Leo Yi Yang, Zhou, Jie, Frise, Rebecca, Goldhill, Daniel H., Koszalka, Paulina, Mifsud, Edin J., Baba, Kaoru, Noda, Takahiro, Ando, Yoshinori, Sato, Kenji, Yuki, Aoe-Ishikawa, Shishido, Takao, Uehara, Takeki, Wildum, Steffen, Zwanziger, Elke, Collinson, Neil, Kuhlbusch, Klaus, Clinch, Barry, Hurt, Aeron C., Barclay, Wendy S.
Publicado 2020