Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

por Uemura, Norihito, Yagi, Hisashi, Uemura, Maiko T., Hatanaka, Yusuke, Yamakado, Hodaka, Takahashi, Ryosuke
Publicado 2018

Correction to: Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

por Uemura, Norihito, Yagi, Hisashi, Uemura, Maiko T., Hatanaka, Yusuke, Yamakado, Hodaka, Takahashi, Ryosuke
Publicado 2019

ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease

por Nakano, Masaki, Imamura, Hiromi, Sasaoka, Norio, Yamamoto, Masamichi, Uemura, Norihito, Shudo, Toshiyuki, Fuchigami, Tomohiro, Takahashi, Ryosuke, Kakizuka, Akira
Publicado 2017

Distinct biological activity of Lewy body α-Synuclein strain in mice

por Uemura, Norihito, Marotta, Nicholas, Ara, Jahan, Meymand, Emily, Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin, Trojanowski, John, Lee, Virginia
Publicado 2023

Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice

por Okuda, Shinya, Nakayama, Takeo, Uemura, Norihito, Hikawa, Rie, Ikuno, Masashi, Yamakado, Hodaka, Inoue, Haruhisa, Tachibana, Naoko, Hayashi, Yu, Takahashi, Ryosuke, Egawa, Naohiro
Publicado 2022

Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

por Nakanishi, Etsuro, Uemura, Norihito, Akiyama, Hisako, Kinoshita, Masato, Masanori, Sawamura, Taruno, Yosuke, Yamakado, Hodaka, Matsuzawa, Shu-ichi, Takeda, Shunichi, Hirabayashi, Yoshio, Takahashi, Ryosuke
Publicado 2021

Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro

por Marotta, Nicholas P., Ara, Jahan, Uemura, Norihito, Lougee, Marshall G., Meymand, Emily S., Zhang, Bin, Petersson, E. James, Trojanowski, John Q., Lee, Virginia M.-Y.
Publicado 2021

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

por Uemura, Norihito, Marotta, Nicholas P., Ara, Jahan, Meymand, Emily S., Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y.
Publicado 2023

Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein

por Uemura, Norihito, Koike, Masato, Ansai, Satoshi, Kinoshita, Masato, Ishikawa-Fujiwara, Tomoko, Matsui, Hideaki, Naruse, Kiyoshi, Sakamoto, Naoaki, Uchiyama, Yasuo, Todo, Takeshi, Takeda, Shunichi, Yamakado, Hodaka, Takahashi, Ryosuke
Publicado 2015

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

por Kaji, Seiji, Maki, Takakuni, Kinoshita, Hisanori, Uemura, Norihito, Ayaki, Takashi, Kawamoto, Yasuhiro, Furuta, Takahiro, Urushitani, Makoto, Hasegawa, Masato, Kinoshita, Yusuke, Ono, Yuichi, Mao, Xiaobo, Quach, Tran H., Iwai, Kazuhiro, Dawson, Valina L., Dawson, Ted M., Takahashi, Ryosuke
Publicado 2018

Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson’s disease

por Matsui, Hideaki, Ito, Shinji, Matsui, Hideki, Ito, Junko, Gabdulkhaev, Ramil, Hirose, Mika, Yamanaka, Tomoyuki, Koyama, Akihide, Kato, Taisuke, Tanaka, Maiko, Uemura, Norihito, Matsui, Noriko, Hirokawa, Sachiko, Yoshihama, Maki, Shimozawa, Aki, Kubo, Shin-ichiro, Iwasaki, Kenji, Hasegawa, Masato, Takahashi, Ryosuke, Hirai, Keisuke, Kakita, Akiyoshi, Onodera, Osamu
Publicado 2023