Cardiodynamic Interactions between Two S1P(1) Receptor Modulators in an Experimental Clinical Setting: Different Pharmacokinetic Properties as an Opportunity to Mitigate First-Dose...

por Juif, Pierre-Eric, Ufer, Mike, Dingemanse, Jasper
Publicado 2019

Clinical Pharmacology of Clazosentan, a Selective Endothelin A Receptor Antagonist for the Prevention and Treatment of aSAH-Related Cerebral Vasospasm

por Juif, Pierre-Eric, Dingemanse, Jasper, Ufer, Mike
Publicado 2021

Pharmacokinetics and Pharmacodynamics of Cenerimod, A Selective S1P(1)R Modulator, Are Not Affected by Ethnicity in Healthy Asian and White Subjects

por Juif, Pierre‐Eric, Dingemanse, Jasper, Winkle, Peter, Ufer, Mike
Publicado 2020

In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics

por Jin, Yi, Borell, Hubert, Gardin, Anne, Ufer, Mike, Huth, Felix, Camenisch, Gian
Publicado 2017

Influence of Rifampin‐Mediated Organic Anion‐Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan

por Juif, Pierre‐Eric, Voors‐Pette, Christine, Ufer, Mike, Dogterom, Peter, Dingemanse, Jasper
Publicado 2019

Effect of Rifampin‐Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel

por Schilling, Uta, Dingemanse, Jasper, Voors‐Pette, Christine, Romeijn, Christel, Dogterom, Peter, Ufer, Mike
Publicado 2020

Impact of siponimod on vaccination response in a randomized, placebo-controlled study

por Ufer, Mike, Shakeri-Nejad, Kasra, Gardin, Anne, Su, Zhenzhong, Paule, Ines, Marbury, Thomas C., Legangneux, Eric
Publicado 2017

A Pooled Analysis of Three Randomized Phase I/IIa Clinical Trials Confirms Absence of a Clinically Relevant Effect on the QTc Interval by Umibecestat

por Vormfelde, Stefan Viktor, Pezous, Nicole, Lefèvre, Gilbert, Kolly, Carine, Neumann, Ulf, Jordaan, Pierre, Ufer, Mike, Legangneux, Eric
Publicado 2020

Effect of Fluconazole Coadministration and CYP2C9 Genetic Polymorphism on Siponimod Pharmacokinetics in Healthy Subjects

por Gardin, Anne, Ufer, Mike, Legangneux, Eric, Rossato, Gianluca, Jin, Yi, Su, Zhenzhong, Pal, Parasar, Li, Wenkui, Shakeri-Nejad, Kasra
Publicado 2018

The challenges of clinical trials in fragile X syndrome

por Jacquemont, Sébastien, Berry-Kravis, Elizabeth, Hagerman, Randi, von Raison, Florian, Gasparini, Fabrizio, Apostol, George, Ufer, Mike, Des Portes, Vincent, Gomez-Mancilla, Baltazar
Publicado 2013

Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients

por Binder, Andreas, May, Denisa, Baron, Ralf, Maier, Christoph, Tölle, Thomas R., Treede, Rolf-Detlef, Berthele, Achim, Faltraco, Frank, Flor, Herta, Gierthmühlen, Janne, Haenisch, Sierk, Huge, Volker, Magerl, Walter, Maihöfner, Christian, Richter, Helmut, Rolke, Roman, Scherens, Andrea, Üçeyler, Nurcan, Ufer, Mike, Wasner, Gunnar, Zhu, Jihong, Cascorbi, Ingolf
Publicado 2011

Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y(12) receptor antagonist, in patients with chronic coronary synd...

por Storey, Robert F, Gurbel, Paul A, ten Berg, Jurrien, Bernaud, Corine, Dangas, George D, Frenoux, Jean-Marie, Gorog, Diana A, Hmissi, Abdel, Kunadian, Vijay, James, Stefan K, Tanguay, Jean-Francois, Tran, Henry, Trenk, Dietmar, Ufer, Mike, Van der Harst, Pim, Van't Hof, Arnoud W J, Angiolillo, Dominick J
Publicado 2019

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

por Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina
Publicado 2018