TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL

por Malik-Chaudhry, Harbani K., Prabhakar, Kirthana, Ugamraj, Harshad S., Boudreau, Andrew A., Buelow, Benjamin, Dang, Kevin, Davison, Laura M., Harris, Katherine E., Jorgensen, Brett, Ogana, Heather, Pham, Duy, Schellenberger, Ute, Van Schooten, Wim, Buelow, Roland, Iyer, Suhasini, Trinklein, Nathan D., Rangaswamy, Udaya S.
Publicado 2021

Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies

por Trinklein, Nathan D., Pham, Duy, Schellenberger, Ute, Buelow, Ben, Boudreau, Andrew, Choudhry, Priya, Clarke, Starlynn C., Dang, Kevin, Harris, Katherine E., Iyer, Suhasini, Jorgensen, Brett, Pratap, Payal P., Rangaswamy, Udaya S., Ugamraj, Harshad S., Vafa, Omid, Wiita, Arun P., van Schooten, Wim, Buelow, Roland, Force Aldred, Shelley
Publicado 2019

TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

por Ugamraj, Harshad S., Dang, Kevin, Ouisse, Laure-Hélène, Buelow, Benjamin, Chini, Eduardo N., Castello, Giulia, Allison, James, Clarke, Starlynn C, Davison, Laura M., Buelow, Roland, Deng, Rong, Iyer, Suhasini, Schellenberger, Ute, Manika, Sankar N., Bijpuria, Shipra, Musnier, Astrid, Poupon, Anne, Cuturi, Maria Cristina, van Schooten, Wim, Dalvi, Pranjali
Publicado 2022

Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release

por Dang, Kevin, Castello, Giulia, Clarke, Starlynn C, Li, Yuping, Balasubramani, Aarti, Boudreau, Andrew, Davison, Laura, Harris, Katherine E, Pham, Duy, Sankaran, Preethi, Ugamraj, Harshad S, Deng, Rong, Kwek, Serena, Starzinski, Alec, Iyer, Suhasini, van Schooten, Wim, Schellenberger, Ute, Sun, Wenchao, Trinklein, Nathan D, Buelow, Roland, Buelow, Ben, Fong, Lawrence, Dalvi, Pranjali
Publicado 2021

Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies

por Harris, Katherine E., Aldred, Shelley Force, Davison, Laura M., Ogana, Heather Anne N., Boudreau, Andrew, Brüggemann, Marianne, Osborn, Michael, Ma, Biao, Buelow, Benjamin, Clarke, Starlynn C., Dang, Kevin H., Iyer, Suhasini, Jorgensen, Brett, Pham, Duy T., Pratap, Payal P., Rangaswamy, Udaya S., Schellenberger, Ute, van Schooten, Wim C., Ugamraj, Harshad S., Vafa, Omid, Buelow, Roland, Trinklein, Nathan D.
Publicado 2018

Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

por Clarke, Starlynn C., Ma, Biao, Trinklein, Nathan D., Schellenberger, Ute, Osborn, Michael J., Ouisse, Laure-Hélène, Boudreau, Andrew, Davison, Laura M., Harris, Katherine E., Ugamraj, Harshad S., Balasubramani, Aarti, Dang, Kevin H., Jorgensen, Brett, Ogana, Heather Anne N., Pham, Duy T., Pratap, Payal P., Sankaran, Preethi, Anegon, Ignacio, van Schooten, Wim C., Brüggemann, Marianne, Buelow, Roland, Force Aldred, Shelley
Publicado 2019

A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer

por Avanzino, Brian C., Prabhakar, Kirthana, Dalvi, Pranjali, Hartstein, Sharon, Kehm, Hannes, Balasubramani, Aarti, Boudreau, Andrew A., Buelow, Ben, Chang, Karen, Davison, Laura M., Iyer, Suhasini, Kalwit, Vidyut, Lewis Wilson, Kristin, Malik-Chaudhry, Harbani K., Pierson, Will, Pineda, Geovanni, Rangaswamy, Udaya S., Saiganesh, Sowmya, Schellenberger, Ute, Ugamraj, Harshad S., Yabut, Rodolfovan D., Buelow, Roland, Chapman, Jocelyn, Trinklein, Nathan D., Harris, Katherine E.
Publicado 2022