TREM2 and microglia exosomes: a potential highway for pathological tau

por Jain, Nimansha, Ulrich, Jason D.
Publicado 2022

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

por Jain, Nimansha, Lewis, Caroline A., Ulrich, Jason D., Holtzman, David M.
Publicado 2022

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

por Mahan, Thomas E., Wang, Chao, Bao, Xin, Choudhury, Ankit, Ulrich, Jason D., Holtzman, David M.
Publicado 2022

APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading

por Wang, Chanung, Nambiar, Aishwarya, Strickland, Michael R., Lee, Choonghee, Parhizkar, Samira, Moore, Alec C., Musiek, Erik S., Ulrich, Jason D., Holtzman, David M.
Publicado 2023

Activated microglia mitigate Aβ-associated tau seeding and spreading

por Gratuze, Maud, Chen, Yun, Parhizkar, Samira, Jain, Nimansha, Strickland, Michael R., Serrano, Javier Remolina, Colonna, Marco, Ulrich, Jason D., Holtzman, David M.
Publicado 2021

Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal

por Kang, Silvia S, Kurti, Aishe, Baker, Kelsey E, Liu, Chia-Chen, Colonna, Marco, Ulrich, Jason D, Holtzman, David M, Bu, Guojun, Fryer, John D
Publicado 2018

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

por Ulrich, Jason D, Finn, Mary Beth, Wang, Yaming, Shen, Alice, Mahan, Thomas E, Jiang, Hong, Stewart, Floy R, Piccio, Laura, Colonna, Marco, Holtzman, David M
Publicado 2014

Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration

por Drieu, Antoine, Du, Siling, Kipnis, Michal, Bosch, Megan E, Herz, Jasmin, Lee, Choonghee, Jiang, Hong, Manis, Melissa, Ulrich, Jason D, Kipnis, Jonathan, Holtzman, David M, Gratuze, Maud
Publicado 2023

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

por Leyns, Cheryl E. G., Ulrich, Jason D., Finn, Mary B., Stewart, Floy R., Koscal, Lauren J., Remolina Serrano, Javier, Robinson, Grace O., Anderson, Elise, Colonna, Marco, Holtzman, David M.
Publicado 2017

TREM2 function impedes tau seeding in neuritic plaques

por Leyns, Cheryl E.G., Gratuze, Maud, Narasimhan, Sneha, Jain, Nimansha, Koscal, Lauren J., Jiang, Hong, Manis, Melissa, Colonna, Marco, Lee, Virginia M.Y., Ulrich, Jason D., Holtzman, David M.
Publicado 2019

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

por Ulrich, Jason D, Burchett, Jack M, Restivo, Jessica L, Schuler, Dorothy R, Verghese, Philip B, Mahan, Thomas E, Landreth, Gary E, Castellano, Joseph M, Jiang, Hong, Cirrito, John R, Holtzman, David M
Publicado 2013

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

por Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E
Publicado 2018

TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model

por Wang, Yaming, Cella, Marina, Mallinson, Kaitlin, Ulrich, Jason D., Young, Katherine L., Robinette, Michelle L., Gifillian, Susan, Krishnan, Gokul M., Sudhakar, Shwetha, Zinselmeyer, Bernd H., Holtzman, David M., Cirrito, John R., Colonna, Marco
Publicado 2015

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

por Huynh, Tien-Phat V., Wang, Chao, Tran, Ainsley C., Tabor, G. Travis, Mahan, Thomas E., Francis, Caroline M., Finn, Mary Beth, Spellman, Rebecca, Manis, Melissa, Tanzi, Rudolph E., Ulrich, Jason D., Holtzman, David M.
Publicado 2019

ApoE facilitates the microglial response to amyloid plaque pathology

por Ulrich, Jason D., Ulland, Tyler K., Mahan, Thomas E., Nyström, Sofie, Nilsson, K. Peter, Song, Wilbur M., Zhou, Yingyue, Reinartz, Mariska, Choi, Seulah, Jiang, Hong, Stewart, Floy R., Anderson, Elise, Wang, Yaming, Colonna, Marco, Holtzman, David M.
Publicado 2018

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

por Wang, Yaming, Ulland, Tyler K., Ulrich, Jason D., Song, Wilbur, Tzaferis, John A., Hole, Justin T., Yuan, Peng, Mahan, Thomas E., Shi, Yang, Gilfillan, Susan, Cella, Marina, Grutzendler, Jaime, DeMattos, Ronald B., Cirrito, John R., Holtzman, David M., Colonna, Marco
Publicado 2016

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma

por Sun, Rui, Han, Rowland, McCornack, Colin, Khan, Saad, Tabor, G. Travis, Chen, Yun, Hou, Jinchao, Jiang, Haowu, Schoch, Kathleen M., Mao, Diane D., Cleary, Ryan, Yang, Alicia, Liu, Qin, Luo, Jingqin, Petti, Allegra, Miller, Timothy M., Ulrich, Jason D., Holtzman, David M., Kim, Albert H.
Publicado 2023

Neuronal VCP loss of function recapitulates FTLD-TDP pathology

por Wani, Abubakar, Zhu, Jiang, Ulrich, Jason D., Eteleeb, Abdallah, Sauerbeck, Andrew D., Reitz, Sydney J., Arhzaouy, Khalid, Ikenaga, Chiseko, Yuede, Carla M., Pittman, Sara K., Wang, Feng, Li, Shan, Benitez, Bruno A., Cruchaga, Carlos, Kummer, Terrance T., Harari, Oscar, Chou, Tsui-Fen, Schröder, Rolf, Clemen, Christoph S., Weihl, Conrad C.
Publicado 2021

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and - independent cellular responses in Alzheimer’s disease

por Zhou, Yingyue, Song, Wilbur M., Andhey, Prabhakar S., Swain, Amanda, Levy, Tyler, Miller, Kelly R., Poliani, Pietro L., Cominelli, Manuela, Grover, Shikha, Gilfillan, Susan, Cella, Marina, Ulland, Tyler K., Zaitsev, Konstantin, Miyashita, Akinori, Ikeuchi, Takeshi, Sainouchi, Makoto, Kakita, Akiyoshi, Bennett, David A., Schneider, Julie A., Nichols, Michael R., Beausoleil, Sean A., Ulrich, Jason, Holtzman, David M., Artyomov, Maxim N., Colonna, Marco
Publicado 2020