Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways

por Karvonen, Hanna, Barker, Harlan, Kaleva, Laura, Niininen, Wilhelmiina, Ungureanu, Daniela
Publicado 2019

Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1

por Grönholm, Juha, Vanhatupa, Sari, Ungureanu, Daniela, Väliaho, Jouni, Laitinen, Tuomo, Valjakka, Jarkko, Silvennoinen, Olli
Publicado 2012

Analysis of Jak2 Catalytic Function by Peptide Microarrays: The Role of the JH2 Domain and V617F Mutation

por Sanz, Arturo, Ungureanu, Daniela, Pekkala, Tuija, Ruijtenbeek, Rob, Touw, Ivo P., Hilhorst, Riet, Silvennoinen, Olli
Publicado 2011

Crystal structures of the Jak2 pseudokinase domain and the pathogenic mutant V617F

por Bandaranayake, Rajintha M., Ungureanu, Daniela, Shan, Yibing, Shaw, David E., Silvennoinen, Olli, Hubbard, Stevan R.
Publicado 2012

Evaluating Targeted Therapies in Ovarian Cancer Metabolism: Novel Role for PCSK9 and Second Generation mTOR Inhibitors

por Jacome Sanz, Dafne, Raivola, Juuli, Karvonen, Hanna, Arjama, Mariliina, Barker, Harlan, Murumägi, Astrid, Ungureanu, Daniela
Publicado 2021

New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome

por Raivola, Juuli, Dini, Alice, Salokas, Kari, Karvonen, Hanna, Niininen, Wilhelmiina, Piki, Emilia, Varjosalo, Markku, Ungureanu, Daniela
Publicado 2022

STRN-ALK rearranged pediatric malignant peritoneal mesothelioma – Functional testing of 527 cancer drugs in patient-derived cancer cells

por Murumägi, Astrid, Ungureanu, Daniela, Arjama, Mariliina, Bützow, Ralf, Lohi, Jouko, Sariola, Hannu, Kanerva, Jukka, Koskenvuo, Minna, Kallioniemi, Olli
Publicado 2021

High-throughput ex vivo drug testing identifies potential drugs and drug combinations for NRAS-positive malignant melanoma

por Kohtamäki, Laura, Arjama, Mariliina, Mäkelä, Siru, Ianevski, Philipp, Välimäki, Katja, Juteau, Susanna, Ilmonen, Suvi, Ungureanu, Daniela, Kallioniemi, Olli, Murumägi, Astrid, Hernberg, Micaela
Publicado 2021

ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity

por Piki, Emilia, Dini, Alice, Raivola, Juuli, Salokas, Kari, Zhang, Kaiyang, Varjosalo, Markku, Pellinen, Teijo, Välimäki, Katja, Veskimäe, Kristina Tabor, Staff, Synnöve, Hautaniemi, Sampsa, Murumägi, Astrid, Ungureanu, Daniela
Publicado 2023

Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness

por Karvonen, Hanna, Arjama, Mariliina, Kaleva, Laura, Niininen, Wilhelmiina, Barker, Harlan, Koivisto-Korander, Riitta, Tapper, Johanna, Pakarinen, Päivi, Lassus, Heini, Loukovaara, Mikko, Bützow, Ralf, Kallioniemi, Olli, Murumägi, Astrid, Ungureanu, Daniela
Publicado 2020

Multiomics characterization implicates PTK7 in ovarian cancer EMT and cell plasticity and offers strategies for therapeutic intervention

por Raivola, Juuli, Dini, Alice, Karvonen, Hanna, Piki, Emilia, Salokas, Kari, Niininen, Wilhelmiina, Kaleva, Laura, Zhang, Kaiyang, Arjama, Mariliina, Gudoityte, Greta, Seashore-Ludlow, Brinton, Varjosalo, Markku, Kallioniemi, Olli, Hautaniemi, Sampsa, Murumägi, Astrid, Ungureanu, Daniela
Publicado 2022

Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma

por Murumägi, Astrid, Ungureanu, Daniela, Khan, Suleiman, Arjama, Mariliina, Välimäki, Katja, Ianevski, Aleksandr, Ianevski, Philipp, Bergström, Rebecka, Dini, Alice, Kanerva, Anna, Koivisto-Korander, Riitta, Tapper, Johanna, Lassus, Heini, Loukovaara, Mikko, Mägi, Andrus, Hirasawa, Akira, Aoki, Daisuke, Pietiäinen, Vilja, Pellinen, Teijo, Bützow, Ralf, Aittokallio, Tero, Kallioniemi, Olli
Publicado 2022