A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects

por Jaramillo-Martinez, Valeria, Ganapathy, Vadivel, Urbatsch, Ina L.
Publicado 2021

Drosophila INDY and Mammalian INDY: Major Differences in Transport Mechanism and Structural Features despite Mostly Similar Biological Functions

por Jaramillo-Martinez, Valeria, Sivaprakasam, Sathish, Ganapathy, Vadivel, Urbatsch, Ina L.
Publicado 2021

Replacing the eleven native tryptophans by directed evolution produces an active P-glycoprotein with site-specific, non-conservative substitutions

por Swartz, Douglas J., Singh, Anukriti, Sok, Narong, Thomas, Joshua N., Weber, Joachim, Urbatsch, Ina L.
Publicado 2020

Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance

por Swartz, Douglas J., Mok, Leo, Botta, Sri K., Singh, Anukriti, Altenberg, Guillermo A., Urbatsch, Ina L.
Publicado 2014

Asymmetry in inward- and outward-affinity constant of transport explain unidirectional lysine flux in Saccharomyces cerevisiae

por Bianchi, Frans, Klooster, Joury S. van ‘t, Ruiz, Stephanie J., Luck, Katja, Pols, Tjeerd, Urbatsch, Ina L., Poolman, Bert
Publicado 2016

Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein

por Tran, Nghi N. B., Bui, A. T. A., Jaramillo-Martinez, Valeria, Weber, Joachim, Zhang, Qinghai, Urbatsch, Ina L.
Publicado 2023

Functional analysis of a species-specific inhibitor selective for human Na(+)-coupled citrate transporter (NaCT/SLC13A5/mINDY)

por Higuchi, Kei, Kopel, Jonathan J., Sivaprakasam, Sathish, Jaramillo-Martinez, Valeria, Sutton, R. Bryan, Urbatsch, Ina L., Ganapathy, Vadivel
Publicado 2020

Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein

por Szewczyk, Paul, Tao, Houchao, McGrath, Aaron P., Villaluz, Mark, Rees, Steven D., Lee, Sung Chang, Doshi, Rupak, Urbatsch, Ina L., Zhang, Qinghai, Chang, Geoffrey
Publicado 2015

A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia pastoris

por Bai, Jiangping, Swartz, Douglas J., Protasevich, Irina I., Brouillette, Christie G., Harrell, Patina M., Hildebrandt, Ellen, Gasser, Brigitte, Mattanovich, Diethard, Ward, Andrew, Chang, Geoffrey, Urbatsch, Ina L.
Publicado 2011