Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types

por Tomasello, Elena, Pollet, Emeline, Vu Manh, Thien-Phong, Uzé, Gilles, Dalod, Marc
Publicado 2014

Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes

por Livingstone, Mark, Sikström, Kristina, Robert, Philippe A., Uzé, Gilles, Larsson, Ola, Pellegrini, Sandra
Publicado 2015

Differential Activity of Type I Interferon Subtypes for Dendritic Cell Differentiation

por Garcin, Geneviève, Bordat, Yann, Chuchana, Paul, Monneron, Danièle, Law, Helen K. W., Piehler, Jacob, Uzé, Gilles
Publicado 2013

Interferons at age 50: past, current and future impact on biomedicine

por Borden, Ernest C., Sen, Ganes C., Uze, Gilles, Silverman, Robert H., Ransohoff, Richard M., Foster, Graham R., Stark, George R.
Publicado 2007

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

por François-Newton, Véronique, Magno de Freitas Almeida, Gabriel, Payelle-Brogard, Béatrice, Monneron, Danièle, Pichard-Garcia, Lydiane, Piehler, Jacob, Pellegrini, Sandra, Uzé, Gilles
Publicado 2011

Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE

por Cauwels, Anje, Van Lint, Sandra, Rogge, Elke, Verhee, Annick, Van Den Eeckhout, Bram, Pang, Shengru, Prinz, Marco, Kley, Niko, Uzé, Gilles, Tavernier, Jan
Publicado 2021

Specific targeting of IL-1β activity to CD8(+) T cells allows for safe use as a vaccine adjuvant

por Van Den Eeckhout, Bram, Van Hoecke, Lien, Burg, Elianne, Van Lint, Sandra, Peelman, Frank, Kley, Niko, Uzé, Gilles, Saelens, Xavier, Tavernier, Jan, Gerlo, Sarah
Publicado 2020

Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells

por Djouad, Farida, Bony, Claire, Häupl, Thomas, Uzé, Gilles, Lahlou, Najiba, Louis-Plence, Pascale, Apparailly, Florence, Canovas, François, Rème, Thierry, Sany, Jacques, Jorgensen, Christian, Noël, Danièle
Publicado 2005

Selective IL-1 activity on CD8(+) T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication

por Van Den Eeckhout, Bram, Huyghe, Leander, Van Lint, Sandra, Burg, Elianne, Plaisance, Stéphane, Peelman, Frank, Cauwels, Anje, Uzé, Gilles, Kley, Niko, Gerlo, Sarah, Tavernier, Jan
Publicado 2021

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

por Wilmes, Stephan, Beutel, Oliver, Li, Zhi, Francois-Newton, Véronique, Richter, Christian P., Janning, Dennis, Kroll, Cindy, Hanhart, Patrizia, Hötte, Katharina, You, Changjiang, Uzé, Gilles, Pellegrini, Sandra, Piehler, Jacob
Publicado 2015

Safe eradication of large established tumors using neovasculature‐targeted tumor necrosis factor‐based therapies

por Huyghe, Leander, Van Parys, Alexander, Cauwels, Anje, Van Lint, Sandra, De Munter, Stijn, Bultinck, Jennyfer, Zabeau, Lennart, Hostens, Jeroen, Goethals, An, Vanderroost, Nele, Verhee, Annick, Uzé, Gilles, Kley, Niko, Peelman, Frank, Vandekerckhove, Bart, Brouckaert, Peter, Tavernier, Jan
Publicado 2020

A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state

por Van Lint, Sandra, Van Parys, Alexander, Van Den Eeckhout, Bram, Vandamme, Niels, Plaisance, Stephane, Verhee, Annick, Catteeuw, Dominiek, Rogge, Elke, De Geest, Jennifer, Vanderroost, Nele, Roels, Jana, Saeys, Yvan, Uzé, Gilles, Kley, Niko, Cauwels, Anje, Tavernier, Jan
Publicado 2023

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

por Bastard, Paul, Hsiao, Kuang-Chih, Zhang, Qian, Choin, Jeremy, Best, Emma, Chen, Jie, Gervais, Adrian, Bizien, Lucy, Materna, Marie, Harmant, Christine, Roux, Maguelonne, Hawley, Nicola L., Weeks, Daniel E., McGarvey, Stephen T., Sandoval, Karla, Barberena-Jonas, Carmina, Quinto-Cortés, Consuelo D., Hagelberg, Erika, Mentzer, Alexander J., Robson, Kathryn, Coulibaly, Boubacar, Seeleuthner, Yoann, Bigio, Benedetta, Li, Zhi, Uzé, Gilles, Pellegrini, Sandra, Lorenzo, Lazaro, Sbihi, Zineb, Latour, Sylvain, Besnard, Marianne, Adam de Beaumais, Tiphaine, Jacqz Aigrain, Evelyne, Béziat, Vivien, Deka, Ranjan, Esera Tulifau, Litara, Viali, Satupa‘itea, Reupena, Muagututi‘a Sefuiva, Naseri, Take, McNaughton, Peter, Sarkozy, Vanessa, Peake, Jane, Blincoe, Annaliesse, Primhak, Sarah, Stables, Simon, Gibson, Kate, Woon, See-Tarn, Drake, Kylie Marie, Hill, Adrian V.S., Chan, Cheng-Yee, King, Richard, Ameratunga, Rohan, Teiti, Iotefa, Aubry, Maite, Cao-Lormeau, Van-Mai, Tangye, Stuart G., Zhang, Shen-Ying, Jouanguy, Emmanuelle, Gray, Paul, Abel, Laurent, Moreno-Estrada, Andrés, Minster, Ryan L., Quintana-Murci, Lluis, Wood, Andrew C., Casanova, Jean-Laurent
Publicado 2022