A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria

por Svetlov, Maxim S., Cohen, Sophie, Alsuhebany, Nada, Vázquez-Laslop, Nora, Mankin, Alexander S.
Publicado 2020

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

por Orelle, Cédric, Szal, Teresa, Klepacki, Dorota, Shaw, Karen J., Vázquez-Laslop, Nora, Mankin, Alexander S.
Publicado 2013

Nascent peptide assists the ribosome in recognizing chemically distinct small molecules

por Gupta, Pulkit, Liu, Bo, Klepacki, Dorota, Gupta, Vrinda, Schulten, Klaus, Mankin, Alexander S., Vázquez-Laslop, Nora
Publicado 2016

A fully orthogonal system for protein synthesis in bacterial cells

por Aleksashin, Nikolay A., Szal, Teresa, d’Aquino, Anne E., Jewett, Michael C., Vázquez-Laslop, Nora, Mankin, Alexander S.
Publicado 2020

The context of the ribosome binding site in mRNAs defines specificity of action of kasugamycin, an inhibitor of translation initiation

por Zhang, Yan, Aleksashin, Nikolay A., Klepacki, Dorota, Anderson, Caleb, Vázquez-Laslop, Nora, Gross, Carol A., Mankin, Alexander S.
Publicado 2022

Dynamics of the context-specific translation arrest by chloramphenicol and linezolid

por Choi, Junhong, Marks, James, Zhang, Jingji, Chen, Dong-Hua, Wang, Jinfan, Vázquez-Laslop, Nora, Mankin, Alexander S., Puglisi, Joseph D.
Publicado 2019

Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria

por Mangano, Kyle, Florin, Tanja, Shao, Xinhao, Klepacki, Dorota, Chelysheva, Irina, Ignatova, Zoya, Gao, Yu, Mankin, Alexander S, Vázquez-Laslop, Nora
Publicado 2020

Discovery of Unannotated Small Open Reading Frames in Streptococcus pneumoniae D39 Involved in Quorum Sensing and Virulence Using Ribosome Profiling

por Laczkovich, Irina, Mangano, Kyle, Shao, Xinhao, Hockenberry, Adam J., Gao, Yu, Mankin, Alexander, Vázquez-Laslop, Nora, Federle, Michael J.
Publicado 2022

Assembly and functionality of the ribosome with tethered subunits

por Aleksashin, Nikolay A., Leppik, Margus, Hockenberry, Adam J., Klepacki, Dorota, Vázquez-Laslop, Nora, Jewett, Michael C., Remme, Jaanus, Mankin, Alexander S.
Publicado 2019

Context-specific action of macrolide antibiotics on the eukaryotic ribosome

por Svetlov, Maxim S., Koller, Timm O., Meydan, Sezen, Shankar, Vaishnavi, Klepacki, Dorota, Polacek, Norbert, Guydosh, Nicholas R., Vázquez-Laslop, Nora, Wilson, Daniel N., Mankin, Alexander S.
Publicado 2021

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome

por Florin, Tanja, Maracci, Cristina, Graf, Michael, Karki, Prajwal, Klepacki, Dorota, Berninghausen, Otto, Beckmann, Roland, Vázquez-Laslop, Nora, Wilson, Daniel N., Rodnina, Marina V., Mankin, Alexander S.
Publicado 2017

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

por Almutairi, Mashal M., Svetlov, Maxim S., Hansen, Douglas A., Khabibullina, Nelli F., Klepacki, Dorota, Kang, Han-Young, Sherman, David H., Vázquez-Laslop, Nora, Polikanov, Yury S., Mankin, Alexander S.
Publicado 2017

Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly

por Huang, Shijie, Aleksashin, Nikolay A., Loveland, Anna B., Klepacki, Dorota, Reier, Kaspar, Kefi, Amira, Szal, Teresa, Remme, Jaanus, Jaeger, Luc, Vázquez-Laslop, Nora, Korostelev, Andrei A., Mankin, Alexander S.
Publicado 2020

Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan

por Martínez, Allyson K., Gordon, Emily, Sengupta, Arnab, Shirole, Nitin, Klepacki, Dorota, Martinez-Garriga, Blanca, Brown, Lewis M., Benedik, Michael J., Yanofsky, Charles, Mankin, Alexander S., Vazquez-Laslop, Nora, Sachs, Matthew S., Cruz-Vera, Luis R.
Publicado 2014

Mechanism of translation inhibition by type II GNAT toxin AtaT2

por Ovchinnikov, Stepan V, Bikmetov, Dmitry, Livenskyi, Alexei, Serebryakova, Marina, Wilcox, Brendan, Mangano, Kyle, Shiriaev, Dmitrii I, Osterman, Ilya A, Sergiev, Petr V, Borukhov, Sergei, Vazquez-Laslop, Nora, Mankin, Alexander S, Severinov, Konstantin, Dubiley, Svetlana
Publicado 2020

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics

por Beckert, Bertrand, Leroy, Elodie C., Sothiselvam, Shanmugapriya, Bock, Lars V., Svetlov, Maxim S., Graf, Michael, Arenz, Stefan, Abdelshahid, Maha, Seip, Britta, Grubmüller, Helmut, Mankin, Alexander S., Innis, C. Axel, Vázquez-Laslop, Nora, Wilson, Daniel N.
Publicado 2021

Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling

por van der Stel, Anne-Xander, Gordon, Emily R., Sengupta, Arnab, Martínez, Allyson K., Klepacki, Dorota, Perry, Thomas N., Herrero del Valle, Alba, Vázquez-Laslop, Nora, Sachs, Matthew S., Cruz-Vera, Luis R., Innis, C. Axel
Publicado 2021