Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?

por Calvier, Elisa A. M., Krekels, Elke H. J., Välitalo, Pyry A. J., Rostami-Hodjegan, Amin, Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A. J.
Publicado 2016

The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models

por Goulooze, Sebastiaan C., Völler, Swantje, Välitalo, Pyry A. J., Calvier, Elisa A. M., Aarons, Leon, Krekels, Elke H. J., Knibbe, Catherijne A. J.
Publicado 2018

Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans

por Aulin, Linda B. S., Valitalo, Pyry A., Rizk, Matthew L., Visser, Sandra A. G., Rao, Gauri, van der Graaf, Piet H., van Hasselt, J. G. Coen
Publicado 2018

Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide

por de Hoogd, Sjoerd, Välitalo, Pyry A. J., Dahan, Albert, van Kralingen, Simone, Coughtrie, Michael M. W., van Dongen, Eric P. A., van Ramshorst, Bert, Knibbe, Catherijne A. J.
Publicado 2017

Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

por van Rongen, Anne, Välitalo, Pyry A. J., Peeters, Mariska Y. M., Boerma, Djamila, Huisman, Fokko W., van Ramshorst, Bert, van Dongen, Eric P. A., van den Anker, Johannes N., Knibbe, Catherijne A. J.
Publicado 2016

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments

por Calvier, Elisa A. M., Krekels, Elke H. J., Yu, Huixin, Välitalo, Pyry A. J., Johnson, Trevor N., Rostami‐Hodjegan, Amin, Tibboel, Dick, van der Graaf, Piet H., Danhof, Meindert, Knibbe, Catherijne A. J.
Publicado 2018

Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults

por van Rongen, Anne, Brill, Margreke J. E., Vaughns, Janelle D., Välitalo, Pyry A. J., van Dongen, Eric P. A., van Ramshorst, Bert, Barrett, Jeffrey S., van den Anker, Johannes N., Knibbe, Catherijne A. J.
Publicado 2017

Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model

por Yamamoto, Yumi, Välitalo, Pyry A., Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Beukers, Margot W., van den Berg, Dirk‐Jan, Hartman, Robin, Wong, Yin Cheong, Danhof, Meindert, van Hasselt, John G. C., de Lange, Elizabeth C. M.
Publicado 2017

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

por Yamamoto, Yumi, Välitalo, Pyry A., van den Berg, Dirk-Jan, Hartman, Robin, van den Brink, Willem, Wong, Yin Cheong, Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Bakshi, Suruchi, Aranzana-Climent, Vincent, Marchand, Sandrine, Dahyot-Fizelier, Claire, Couet, William, Danhof, Meindert, van Hasselt, Johan G. C., de Lange, Elizabeth C. M.
Publicado 2016