The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells

por Limaye, Vidya, Vadas, Mathew A., Pitson, Stuart M., Gamble, Jennifer R.
Publicado 2009

Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies

por Lichtenstein, Ilana, Charleston, Michael A, Caetano, Tiberio S, Gamble, Jennifer R, Vadas, Mathew A
Publicado 2013

The aging endothelium

por Ting, Ka Ka, Coleman, Paul, Zhao, Yang, Vadas, Mathew A, Gamble, Jennifer R
Publicado 2021

Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells

por Coleman, Paul R., Chang, Garry, Hutas, Gabor, Grimshaw, Matthew, Vadas, Mathew A., Gamble, Jennifer R.
Publicado 2013

The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b

por Li, Jia, Zhao, Yang, Lu, Ying, Ritchie, William, Grau, Georges, Vadas, Mathew A, Gamble, Jennifer R
Publicado 2016

Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells

por Limaye, Vidya, Xia, Pu, Hahn, Chris, Smith, Malcolm, Vadas, Mathew A., Pitson, Stuart M., Gamble, Jennifer R.
Publicado 2009

YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment

por Coleman, Paul R., Lay, Angelina J., Ting, Ka Ka, Zhao, Yang, Li, Jia, Jarrah, Sorour, Vadas, Mathew A., Gamble, Jennifer R.
Publicado 2020

Caveolae control the anti-inflammatory phenotype of senescent endothelial cells

por Powter, Elizabeth E, Coleman, Paul R, Tran, Mai H, Lay, Angelina J, Bertolino, Patrick, Parton, Robert G, Vadas, Mathew A, Gamble, Jennifer R
Publicado 2015

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1

por Sukocheva, Olga, Wadham, Carol, Holmes, Andrew, Albanese, Nathaniel, Verrier, Emily, Feng, Feng, Bernal, Alex, Derian, Claudia K., Ullrich, Axel, Vadas, Mathew A., Xia, Pu
Publicado 2006

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

por Pitson, Stuart M., Xia, Pu, Leclercq, Tamara M., Moretti, Paul A.B., Zebol, Julia R., Lynn, Helen E., Wattenberg, Binks W., Vadas, Mathew A.
Publicado 2005

ARHGAP18: A Flow‐Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis

por Lay, Angelina J., Coleman, Paul R., Formaz‐Preston, Ann, Ting, Ka Ka, Roediger, Ben, Weninger, Wolfgang, Schwartz, Martin A., Vadas, Mathew A., Gamble, Jennifer R.
Publicado 2019

Identification of circulating sphingosine kinase-related metabolites for prediction of type 2 diabetes

por Chen, Qi, Wang, Wei, Xia, Ming-Feng, Lu, You-li, Bian, Hua, Yu, Chen, Li, Xiao-Ying, Vadas, Mathew A., Gao, Xin, Lin, Huan-Dong, Xia, Pu
Publicado 2021

Novel miRNA-based drug CD5-2 reduces liver tumor growth in diethylnitrosamine-treated mice by normalizing tumor vasculature and altering immune infiltrate

por Liu, Ken, Chen, Jinbiao, Zhao, Yang, Boland, Jade, Ting, Ka Ka, Lockwood, Glen, McKenzie, Catriona, Kench, James, Vadas, Mathew A., Gamble, Jennifer R., McCaughan, Geoffrey W.
Publicado 2023

Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice

por Chen, Jinbiao, Qi, Yanfei, Zhao, Yang, Kaczorowski, Dominik, Couttas, Timothy A., Coleman, Paul R., Don, Anthony S., Bertolino, Patrick, Gamble, Jennifer R., Vadas, Mathew A., Xia, Pu, McCaughan, Geoffrey W.
Publicado 2018

Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice

por Li, Jia, Zhao, Yang, Choi, Jaesung, Ting, Ka Ka, Coleman, Paul, Chen, Jinbiao, Cogger, Victoria C., Wan, Li, Shi, Zhongsong, Moller, Thorleif, Zheng, Xiangjian, Vadas, Mathew A., Gamble, Jennifer R.
Publicado 2020

Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models

por Ting, Ka Ka, Coleman, Paul, Kim, Hani Jieun, Zhao, Yang, Mulangala, Jocelyne, Cheng, Ngan Ching, Li, Wan, Gunatilake, Dilini, Johnstone, Daniel M., Loo, Lipin, Neely, G. Gregory, Yang, Pengyi, Götz, Jürgen, Vadas, Mathew A., Gamble, Jennifer R.
Publicado 2023

The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells

por Lovelace, Michael D., Powter, Elizabeth E., Coleman, Paul R., Zhao, Yang, Parker, Amelia, Chang, Garry H., Lay, Angelina J., Hunter, Julie, McGrath, Aaron P., Jormakka, Mika, Bertolino, Patrick, McCaughan, Geoffrey, Kavallaris, Maria, Vadas, Mathew A., Gamble, Jennifer R.
Publicado 2017

Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7

por Chen, Jinbiao, Zhao, Yang, Zhang, Fan, Li, Jia, Boland, Jade A., Cheng, Ngan Ching, Liu, Ken, Tiffen, Jessamy C., Bertolino, Patrick, Bowen, David G., Krueger, Andreas, Lisowski, Leszek, Alexander, Ian E., Vadas, Mathew A., El-Omar, Emad, Gamble, Jennifer R., McCaughan, Geoffrey W.
Publicado 2022

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2

por Aji, Gulibositan, Huang, Yu, Ng, Mei Li, Wang, Wei, Lan, Tian, Li, Min, Li, Yufei, Chen, Qi, Li, Rui, Yan, Sishan, Tran, Collin, Burchfield, James G., Couttas, Timothy A., Chen, Jinbiao, Chung, Long Hoa, Liu, Da, Wadham, Carol, Hogg, Philip J., Gao, Xin, Vadas, Mathew A., Gamble, Jennifer R., Don, Anthony S., Xia, Pu, Qi, Yanfei
Publicado 2020