Allele-Specific Transcriptional Activity at Type 2 Diabetes–Associated Single Nucleotide Polymorphisms in Regions of Pancreatic Islet Open Chromatin at the JAZF1 Locus

por Fogarty, Marie P., Panhuis, Tami M., Vadlamudi, Swarooparani, Buchkovich, Martin L., Mohlke, Karen L.
Publicado 2013

Identification of a Regulatory Variant That Binds FOXA1 and FOXA2 at the CDC123/CAMK1D Type 2 Diabetes GWAS Locus

por Fogarty, Marie P., Cannon, Maren E., Vadlamudi, Swarooparani, Gaulton, Kyle J., Mohlke, Karen L.
Publicado 2014

Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci

por Perrin, Hannah J., Currin, Kevin W., Vadlamudi, Swarooparani, Pandey, Gautam K., Ng, Kenneth K., Wabitsch, Martin, Laakso, Markku, Love, Michael I., Mohlke, Karen L.
Publicado 2021

Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits

por Orchard, Peter, Manickam, Nandini, Ventresca, Christa, Vadlamudi, Swarooparani, Varshney, Arushi, Rai, Vivek, Kaplan, Jeremy, Lalancette, Claudia, Mohlke, Karen L., Gallagher, Katherine, Burant, Charles F., Parker, Stephen C.J.
Publicado 2021

Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits

por Cannon, Maren E., Currin, Kevin W., Young, Kristin L., Perrin, Hannah J., Vadlamudi, Swarooparani, Safi, Alexias, Song, Lingyun, Wu, Ying, Wabitsch, Martin, Laakso, Markku, Crawford, Gregory E., Mohlke, Karen L.
Publicado 2019

Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey

por Spracklen, Cassandra N., Shi, Jinxiu, Vadlamudi, Swarooparani, Wu, Ying, Zou, Meng, Raulerson, Chelsea K., Davis, James P., Zeynalzadeh, Monica, Jackson, Kayla, Yuan, Wentao, Wang, Haifeng, Shou, Weihua, Wang, Ying, Luo, Jingchun, Lange, Leslie A., Lange, Ethan M., Popkin, Barry M., Gordon-Larsen, Penny, Du, Shufa, Huang, Wei, Mohlke, Karen L.
Publicado 2018

Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits

por Brotman, Sarah M., Oravilahti, Anniina, Rosen, Jonathan D., Alvarez, Marcus, Heinonen, Sini, van der Kolk, Birgitta W., Fernandes Silva, Lilian, Perrin, Hannah J., Vadlamudi, Swarooparani, Pylant, Cortney, Deochand, Sonia, Basta, Patricia V., Valone, Jordan M., Narain, Morgan N., Stringham, Heather M., Boehnke, Michael, Kuusisto, Johanna, Love, Michael I., Pietiläinen, Kirsi H., Pajukanta, Päivi, Laakso, Markku, Mohlke, Karen L.
Publicado 2023

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences

por Spracklen, Cassandra N., Iyengar, Apoorva K., Vadlamudi, Swarooparani, Raulerson, Chelsea K., Jackson, Anne U., Brotman, Sarah M., Wu, Ying, Cannon, Maren E., Davis, James P., Crain, Aaron T., Currin, Kevin W., Perrin, Hannah J., Narisu, Narisu, Stringham, Heather M., Fuchsberger, Christian, Locke, Adam E., Welch, Ryan P., Kuusisto, Johanna K., Pajukanta, Päivi, Scott, Laura J., Li, Yun, Collins, Francis S., Boehnke, Michael, Laakso, Markku, Mohlke, Karen L.
Publicado 2020

The genetic regulatory signature of type 2 diabetes in human skeletal muscle

por Scott, Laura J., Erdos, Michael R., Huyghe, Jeroen R., Welch, Ryan P., Beck, Andrew T., Wolford, Brooke N., Chines, Peter S., Didion, John P., Narisu, Narisu, Stringham, Heather M., Taylor, D. Leland, Jackson, Anne U., Vadlamudi, Swarooparani, Bonnycastle, Lori L., Kinnunen, Leena, Saramies, Jouko, Sundvall, Jouko, Albanus, Ricardo D'Oliveira, Kiseleva, Anna, Hensley, John, Crawford, Gregory E., Jiang, Hui, Wen, Xiaoquan, Watanabe, Richard M., Lakka, Timo A., Mohlke, Karen L., Laakso, Markku, Tuomilehto, Jaakko, Koistinen, Heikki A., Boehnke, Michael, Collins, Francis S., Parker, Stephen C. J.
Publicado 2016

Adipose tissue eQTL meta-analysis reveals the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits

por Brotman, Sarah M., El-Sayed Moustafa, Julia S., Guan, Li, Broadaway, K. Alaine, Wang, Dongmeng, Jackson, Anne U., Welch, Ryan, Currin, Kevin W., Tomlinson, Max, Vadlamudi, Swarooparani, Stringham, Heather M., Roberts, Amy L., Lakka, Timo A., Oravilahti, Anniina, Silva, Lilian Fernandes, Narisu, Narisu, Erdos, Michael R., Yan, Tingfen, Bonnycastle, Lori L., Raulerson, Chelsea K., Raza, Yasrab, Yan, Xinyu, Parker, Stephen C.J., Kuusisto, Johanna, Pajukanta, Päivi, Tuomilehto, Jaakko, Collins, Francis S., Boehnke, Michael, Love, Michael I., Koistinen, Heikki A., Laakso, Markku, Mohlke, Karen L., Small, Kerrin S., Scott, Laura J.
Publicado 2023

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

por Viñuela, Ana, Varshney, Arushi, van de Bunt, Martijn, Prasad, Rashmi B., Asplund, Olof, Bennett, Amanda, Boehnke, Michael, Brown, Andrew A., Erdos, Michael R., Fadista, João, Hansson, Ola, Hatem, Gad, Howald, Cédric, Iyengar, Apoorva K., Johnson, Paul, Krus, Ulrika, MacDonald, Patrick E., Mahajan, Anubha, Manning Fox, Jocelyn E., Narisu, Narisu, Nylander, Vibe, Orchard, Peter, Oskolkov, Nikolay, Panousis, Nikolaos I., Payne, Anthony, Stitzel, Michael L., Vadlamudi, Swarooparani, Welch, Ryan, Collins, Francis S., Mohlke, Karen L., Gloyn, Anna L., Scott, Laura J., Dermitzakis, Emmanouil T., Groop, Leif, Parker, Stephen C. J., McCarthy, Mark I.
Publicado 2020

Genome-wide association study and functional characterisation identifies candidate genes for insulin-stimulated glucose uptake

por Williamson, Alice, Norris, Dougall M, Yin, Xianyong, Broadaway, K. Alaine, Moxley, Anne H, Vadlamudi, Swarooparani, Wilson, Emma P, Jackson, Anne U, Ahuja, Vasudha, Andersen, Mette K, Arzumanyan, Zorayr, Bonnycastle, Lori L, Bornstein, Stefan R, Bretschneider, Maxi P., Buchanan, Thomas A, Chang, Yi-Cheng, Chuang, Lee-Ming, Chung, Ren-Hua, Clausen, Tine D, Damm, Peter, Delgado, Graciela E, de Mello, Vanessa D, Dupuis, Josée, Dwivedi, Om P, Erdos, Michael R, Silva, Lilian Fernandes, Frayling, Timothy M, Gieger, Christian, Goodarzi, Mark O, Guo, Xiuqing, Gustafsson, Stefan, Hakaste, Liisa, Hammar, Ulf, Hatem, Gad, Herrmann, Sandra, Højlund, Kurt, Horn, Katrin, Hsueh, Willa A, Hung, Yi-Jen, Hwu, Chii-Min, Jonsson, Anna, Kårhus, Line L, Kleber, Marcus E, Kovacs, Peter, Lakka, Timo A, Lauzon, Marie, Lee, I-Te, Lindgren, Cecilia M, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Luan, Jian'an, Aly, Dina Mansour, Mathiesen, Elisabeth, Moissl, Angela P, Morris, Andrew P, Narisu, Narisu, Perakakis, Nikolaos, Peters, Annette, Prasad, Rashmi B, Rodionov, Roman N, Roll, Kathryn, Rundsten, Carsten F, Sarnowski, Chloé, Savonen, Kai, Scholz, Markus, Sharma, Sapna, Stinson, Sara E, Suleman, Sufyan, Tan, Jingyi, Taylor, Kent D, Uusitupa, Matti, Vistisen, Dorte, Witte, Daniel R, Walther, Romy, Wu, Peitao, Xiang, Anny H, Zethelius, Björn, Ahlqvist, Emma, Bergman, Richard N, Chen, Yii-Der Ida, Collins, Francis S, Fall, Tove, Florez, Jose C, Fritsche, Andreas, Grallert, Harald, Groop, Leif, Hansen, Torben, Koistinen, Heikki A, Komulainen, Pirjo, Laakso, Markku, Lind, Lars, Loeffler, Markus, März, Winfried, Meigs, James B, Raffel, Leslie J, Rauramaa, Rainer, Rotter, Jerome I, Schwarz, Peter E. H., Stumvoll, Michael, Sundström, Johan, Tönjes, Anke, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Wagner, Robert, Barroso, Inês, Walker, Mark, Grarup, Niels, Boehnke, Michael, Wareham, Nicholas J, Mohlke, Karen L, Wheeler, Eleanor, O’Rahilly, Stephen, Fazakerley, Daniel J, Langenberg, Claudia
Publicado 2023