Encorafenib Acts as a Dual-Activity Chemosensitizer through Its Inhibitory Effect on ABCC1 Transporter In Vitro and Ex Vivo

por Zhang, Yu, Vagiannis, Dimitrios, Budagaga, Youssif, Sabet, Ziba, Hanke, Ivo, Rozkoš, Tomáš, Hofman, Jakub
Publicado 2022

Talazoparib Does Not Interact with ABCB1 Transporter or Cytochrome P450s, but Modulates Multidrug Resistance Mediated by ABCC1 and ABCG2: An in Vitro and Ex Vivo Study

por Sabet, Ziba, Vagiannis, Dimitrios, Budagaga, Youssif, Zhang, Yu, Novotná, Eva, Hanke, Ivo, Rozkoš, Tomáš, Hofman, Jakub
Publicado 2022

Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme

por Vagiannis, Dimitrios, Novotna, Eva, Skarka, Adam, Kammerer, Sarah, Küpper, Jan-Heiner, Chen, Si, Guo, Lei, Staud, Frantisek, Hofman, Jakub
Publicado 2020

Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo

por Vagiannis, Dimitrios, Budagaga, Youssif, Morell, Anselm, Zhang, Yu, Novotná, Eva, Skarka, Adam, Kammerer, Sarah, Küpper, Jan-Heiner, Hanke, Ivo, Rozkoš, Tomáš, Hofman, Jakub
Publicado 2021