Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer

por Wei, Guangyan, An, Ping, Vaid, Kahini A., Nasser, Imad, Huang, Pinzhu, Tan, Li, Zhao, Shuangshuang, Schuppan, Detlef, Popov, Yury V.
Publicado 2020

Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

por An, Ping, Wei, Lin-Lin, Zhao, Shuangshuang, Sverdlov, Deanna Y., Vaid, Kahini A., Miyamoto, Makoto, Kuramitsu, Kaori, Lai, Michelle, Popov, Yury V.
Publicado 2020

Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal

por Ikenaga, Naoki, Peng, Zhen-Wei, Vaid, Kahini A, Liu, Susan B, Yoshida, Shuhei, Sverdlov, Deanna Y, Mikels-Vigdal, Amanda, Smith, Victoria, Schuppan, Detlef, Popov, Yury V
Publicado 2017

A novel non‐bile acid FXR agonist EDP‐305 potently suppresses liver injury and fibrosis without worsening of ductular reaction

por An, Ping, Wei, Guangyan, Huang, Pinzhu, Li, Wenda, Qi, Xiaolong, Lin, Yi, Vaid, Kahini A., Wang, Jun, Zhang, Shucha, Li, Yang, Or, Yat Sun, Jiang, Li‐Juan, Popov, Yury V.
Publicado 2020

The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis

por Peng, Zhen‐Wei, Rothweiler, Sonja, Wei, Guangyan, Ikenaga, Naoki, Liu, Susan B., Sverdlov, Deanna Y., Vaid, Kahini A., Longhi, Maria Serena, Kuang, Ming, Robson, Simon C., Popov, Yury V.
Publicado 2017

Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c.Abcb4(−/−) mouse model of PFIC3

por Wei, Guangyan, Cao, Jingsong, Huang, Pinzhu, An, Ping, Badlani, Disha, Vaid, Kahini A., Zhao, Shuangshuang, Wang, David Q-H., Zhuo, Jenny, Yin, Ling, Frassetto, Andrea, Markel, Arianna, Presnyak, Vladimir, Gandham, Srujan, Hua, Serenus, Lukacs, Christine, Finn, Patrick F., Giangrande, Paloma H., Martini, Paolo G.V., Popov, Yury V.
Publicado 2020