Screening for Novel Inhibitors of Amyloid Beta Aggregation and Toxicity as Potential Drugs for Alzheimer’s Disease

por Sharari, Sanaa, Vaikath, Nishant N., Tsakou, Magdalini, Ghanem, Simona S., Vekrellis, Kostas
Publicado 2023

RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies

por Poggiolini, Ilaria, Erskine, Daniel, Vaikath, Nishant N., Ponraj, Janarthanan, Mansour, Said, Morris, Christopher M., El-Agnaf, Omar M. A.
Publicado 2021

Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity

por Ghanem, Simona S., Fayed, Hend S., Zhu, Qi, Lu, Jia-Hong, Vaikath, Nishant N., Ponraj, Janarthanan, Mansour, Said, El-Agnaf, Omar M. A.
Publicado 2021

Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies

por Gupta, Vijay, Sudhakaran, Indulekha P., Islam, Zeyaul, Vaikath, Nishant N., Hmila, Issam, Lukacsovich, Tamas, Kolatkar, Prasanna R., El-Agnaf, Omar M. A.
Publicado 2020

Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease

por Majbour, Nour K., Chiasserini, Davide, Vaikath, Nishant N., Eusebi, Paolo, Tokuda, Takahiko, van de Berg, Wilma, Parnetti, Lucilla, Calabresi, Paolo, El-Agnaf , Omar M. A.
Publicado 2017

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

por Wu, Jia-Zhen, Ardah, Mustafa, Haikal, Caroline, Svanbergsson, Alexander, Diepenbroek, Meike, Vaikath, Nishant N., Li, Wen, Wang, Zhan-You, Outeiro, Tiago F., El-Agnaf, Omar M., Li, Jia-Yi
Publicado 2019

Investigating the presence of doubly phosphorylated α‐synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases

por Fayyad, Muneera, Erskine, Daniel, Majbour, Nour K., Vaikath, Nishant N., Ghanem, Simona S., Sudhakaran, Indulekha P., Abdesselem, Houari, Lamprokostopoulou, Agaristi, Vekrellis, Kostas, Morris, Christopher M., Attems, Johannes, El‐Agnaf, Omar M. A.
Publicado 2020

Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts

por Ardah, Mustafa T., Ghanem, Simona S., Abdulla, Sara A., Lv, Guohua, Emara, Mohamed M., Paleologou, Katerina E., Vaikath, Nishant N., Lu, Jia-Hong, Li, Min, Vekrellis, Konstantinos, Eliezer, David, El-Agnaf, Omar M. A.
Publicado 2020

α‐Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies

por van Steenoven, Inger, Majbour, Nour K., Vaikath, Nishant N., Berendse, Henk W., van der Flier, Wiesje M., van de Berg, Wilma D.J., Teunissen, Charlotte E., Lemstra, Afina W., El‐Agnaf, Omar M.A.
Publicado 2018

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers

por Majbour, Nour K., Aasly, Jan O., Hustad, Eldbjørg, Thomas, Mercy A., Vaikath, Nishant N., Elkum, Naser, van de Berg, Wilma D. J., Tokuda, Takahiko, Mollenhauer, Brit, Berendse, Henk W., El-Agnaf, Omar M. A.
Publicado 2020

Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity

por Gupta, Vijay, Salim, Safa, Hmila, Issam, Vaikath, Nishant N., Sudhakaran, Indulekha P., Ghanem, Simona S., Majbour, Nour K., Abdulla, Sara A., Emara, Mohamed M., Abdesselem, Houari B., Lukacsovich, Tamas, Erskine, Daniel, El-Agnaf, Omar M. A.
Publicado 2020

Novel engineered nanobodies specific for N‐terminal region of alpha‐synuclein recognize Lewy‐body pathology and inhibit in‐vitro seeded aggregation and toxicity

por Hmila, Issam, Vaikath, Nishant N., Majbour, Nour K., Erskine, Daniel, Sudhakaran, Indulekha P., Gupta, Vijay, Ghanem, Simona S., Islam, Zeyaul, Emara, Mohamed M., Abdesselem, Houari B., Kolatkar, Prasanna R., Achappa, Devaya K., Vinardell, Tatiana, El‐Agnaf, Omar M. A.
Publicado 2022

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease

por Majbour, Nour K., Vaikath, Nishant N., van Dijk, Karin D., Ardah, Mustafa T., Varghese, Shiji, Vesterager, Louise B., Montezinho, Liliana P., Poole, Stephen, Safieh-Garabedian, Bared, Tokuda, Takahiko, Teunissen, Charlotte E., Berendse, Henk W., van de Berg, Wilma D. J., El-Agnaf, Omar M. A.
Publicado 2016

Uncovering a neurological protein signature for severe COVID-19

por El-Agnaf, Omar, Bensmail, Ilham, Al-Nesf, Maryam A.Y., Flynn, James, Taylor, Mark, Majbour, Nour K., Abdi, Ilham Y., Vaikath, Nishant N., Farooq, Abdulaziz, Vemulapalli, Praveen B., Schmidt, Frank, Ouararhni, Khalid, Al-Siddiqi, Heba H., Arredouani, Abdelilah, Wijten, Patrick, Al-Maadheed, Mohammed, Mohamed-Ali, Vidya, Decock, Julie, Abdesselem, Houari B.
Publicado 2023

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

por Duffy, Megan F., Collier, Timothy J., Patterson, Joseph R., Kemp, Christopher J., Luk, Kelvin C., Tansey, Malú G., Paumier, Katrina L., Kanaan, Nicholas M., Fischer, Luke D., Polinski, Nicole K., Barth, Olivia L., Howe, Jacob W., Vaikath, Nishant N., Majbour, Nour K., El-Agnaf, Omar M. A., Sortwell, Caryl E.
Publicado 2018

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

por Duffy, Megan F., Collier, Timothy J., Patterson, Joseph R., Kemp, Christopher J., Luk, Kelvin C., Tansey, Malú G., Paumier, Katrina L., Kanaan, Nicholas M., Fischer, D. Luke, Polinski, Nicole K., Barth, Olivia L., Howe, Jacob W., Vaikath, Nishant N., Majbour, Nour K., El-Agnaf, Omar M. A., Sortwell, Caryl E.
Publicado 2018

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

por Ghanem, Simona S., Majbour, Nour K., Vaikath, Nishant N., Ardah, Mustafa T., Erskine, Daniel, Jensen, Nanna Møller, Fayyad, Muneera, Sudhakaran, Indulekha P., Vasili, Eftychia, Melachroinou, Katerina, Abdi, Ilham Y., Poggiolini, Ilaria, Santos, Patricia, Dorn, Anton, Carloni, Paolo, Vekrellis, Kostas, Attems, Johannes, McKeith, Ian, Outeiro, Tiago F., Jensen, Poul Henning, El-Agnaf, Omar M. A.
Publicado 2022

Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system

por Schmidt, Frank, Abdesselem, Houari B., Suhre, Karsten, Vaikath, Nishant N., Sohail, Muhammad U., Al-Nesf, Maryam, Bensmail, Ilham, Mashod, Fathima, Sarwath, Hina, Bernhardt, Joerg, Schaefer-Ramadan, Stephanie, Tan, Ti-Myen, Morris, Priscilla E., Schenck, Edward J., Price, David, Mohamed-Ali, Vidya, Al-Maadheed, Mohammed, Arredouani, Abdelilah, Decock, Julie, Blackburn, Jonathan M., Choi, Augustine M. K., El-Agnaf, Omar M.
Publicado 2023

Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort

por Smith, Muneerah, Abdesselem, Houari B., Mullins, Michelle, Tan, Ti-Myen, Nel, Andrew J. M., Al-Nesf, Maryam A. Y., Bensmail, Ilham, Majbour, Nour K., Vaikath, Nishant N., Naik, Adviti, Ouararhni, Khalid, Mohamed-Ali, Vidya, Al-Maadheed, Mohammed, Schell, Darien T., Baros-Steyl, Seanantha S., Anuar, Nur D., Ismail, Nur H., Morris, Priscilla E., Mamat, Raja N. R., Rosli, Nurul S. M., Anwar, Arif, Ellan, Kavithambigai, Zain, Rozainanee M., Burgers, Wendy A., Mayne, Elizabeth S., El-Agnaf, Omar M. A., Blackburn, Jonathan M.
Publicado 2021