Quantitative Measurement of the Target-Mediated Internalization Kinetics of Biopharmaceuticals

por Vainshtein, Inna, Roskos, Lorin K., Cheng, Jackie, Sleeman, Matthew A., Wang, Bing, Liang, Meina
Publicado 2014

Multiplexing of receptor occupancy measurements for pharmacodynamic biomarker assessment of biopharmaceuticals

por Vainshtein, Inna, Schneider, Amy K., Sun, Bo, Schwickart, Martin, Roskos, Lorin K., Liang, Meina
Publicado 2015

Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody

por Cheng, Jackie, Liang, Meina, Carvalho, Miguel F., Tigue, Natalie, Faggioni, Raffaella, Roskos, Lorin K., Vainshtein, Inna
Publicado 2020

Receptor occupancy assessment by flow cytometry as a pharmacodynamic biomarker in biopharmaceutical development

por Liang, Meina, Schwickart, Martin, Schneider, Amy K., Vainshtein, Inna, Del Nagro, Christopher, Standifer, Nathan, Roskos, Lorin K.
Publicado 2015

Evaluation of assay interference and interpretation of CXCR4 receptor occupancy results in a preclinical study with MEDI3185, a fully human antibody to CXCR4

por Schwickart, Martin, Chavez, Carlos, Henderson, Simon, Vainshtein, Inna, Standifer, Nathan, DelNagro, Christopher, Mehrzai, Freshta, Schneider, Amy, Roskos, Lorin, Liang, Meina
Publicado 2015

Development and analytical performance of a new ARCHITECT automated dipeptidyl peptidase-4 immunoassay

por Hemken, Philip M., Jeanblanc, Nicolette M., Rae, Tracey, Brophy, Susan E., Datwyler, Maria J., Xu, Ying, Manetz, T. Scott, Vainshtein, Inna, Liang, Meina, Xiao, Xiaodong, Chowdhury, Partha S., Chang, Chien-ying, Streicher, Katie, Greenlees, Lydia, Ranade, Koustubh, Davis, Gerard J.
Publicado 2017

Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus

por Riggs, Jeffrey M, Hanna, Richard N, Rajan, Bhargavi, Zerrouki, Kamelia, Karnell, Jodi L, Sagar, Divya, Vainshtein, Inna, Farmer, Erika, Rosenthal, Kimberly, Morehouse, Chris, de los Reyes, Melissa, Schifferli, Kevin, Liang, Meina, Sanjuan, Miguel A, Sims, Gary P, Kolbeck, Roland
Publicado 2018