Disabling an oncogenic transcription factor by targeting of control kinases

por Vakoc, Christopher R., Kentsis, Alex
Publicado 2018

Oncogene interference through targeting of chromatin regulators

por Roe, Jae-Seok, Vakoc, Christopher R.
Publicado 2013

C/EBPα: critical at the origin of leukemic transformation

por Roe, Jae-Seok, Vakoc, Christopher R.
Publicado 2014

ACE: a probabilistic model for characterizing gene-level essentiality in CRISPR screens

por Hutton, Elizabeth R., Vakoc, Christopher R., Siepel, Adam
Publicado 2021

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

por Shi, Junwei, Wang, Eric, Milazzo, Joseph P., Wang, Zhihua, Kinney, Justin B., Vakoc, Christopher R.
Publicado 2015

In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of myeloid leukemia development in mice

por Li, Bin E., Li, Grace Y., Cai, Wenqing, Zhu, Qian, Seruggia, Davide, Fujiwara, Yuko, Vakoc, Christopher R., Orkin, Stuart H.
Publicado 2023

Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinoma

por Maia-Silva, Diogo, Schier, Allison C., Skopelitis, Damianos, Kechejian, Vahag, Alpsoy, Aktan, Liverpool, Jynelle, Taatjes, Dylan J., Vakoc, Christopher R.
Publicado 2023

Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis

por Ipsaro, Jonathan J., Shen, Chen, Arai, Eri, Xu, Yali, Kinney, Justin B., Joshua-Tor, Leemor, Vakoc, Christopher R., Shi, Junwei
Publicado 2017

TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis

por Yu, Jia-Ray, Tai, Yilin, Jin, Ying, Hammell, Molly C., Wilkinson, J. Erby, Roe, Jae-Seok, Vakoc, Christopher R., Van Aelst, Linda
Publicado 2015

p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinoma

por Hur, Stella K., Somerville, Tim D.D., Wu, Xiaoli S., Maia-Silva, Diogo, Demerdash, Osama E., Tuveson, David A., Notta, Faiyaz, Vakoc, Christopher R.
Publicado 2023

The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer

por Wang, Eric, Kawaoka, Shinpei, Roe, Jae-Seok, Shi, Junwei, Hohmann, Anja F, Xu, Yali, Bhagwat, Anand S, Suzuki, Yutaka, Kinney, Justin B, Vakoc, Christopher R
Publicado 2015

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

por Somerville, Tim D.D., Xu, Yali, Miyabayashi, Koji, Tiriac, Hervé, Cleary, Cristian R., Maia-Silva, Diogo, Milazzo, Joseph P., Tuveson, David A., Vakoc, Christopher R.
Publicado 2018

Tankyrase inhibition sensitizes cells to CDK4 blockade

por Foronda, Miguel, Tarumoto, Yusuke, Schatoff, Emma M., Leach, Benjamin I., Diaz, Bianca J., Zimmerman, Jill, Goswami, Sukanya, Shusterman, Michael, Vakoc, Christopher R., Dow, Lukas E.
Publicado 2019

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)

por Herrmann, Harald, Blatt, Katharina, Shi, Junwei, Gleixner, Karoline V., Cerny-Reiterer, Sabine, Müllauer, Leonhard, Vakoc, Christopher R., Sperr, Wolfgang R., Horny, Hans-Peter, Bradner, James E., Zuber, Johannes, Valent, Peter
Publicado 2012

Comparative optimization of combinatorial CRISPR screens

por Li, Ruitong, Klingbeil, Olaf, Monducci, Davide, Young, Michael J., Rodriguez, Diego J., Bayyat, Zaid, Dempster, Joshua M., Kesar, Devishi, Yang, Xiaoping, Zamanighomi, Mahdi, Vakoc, Christopher R., Ito, Takahiro, Sellers, William R.
Publicado 2022

The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

por Chou, Hsiang-Chen, Bhalla, Kuhulika, Demerdesh, Osama EL, Klingbeil, Olaf, Hanington, Kaarina, Aganezov, Sergey, Andrews, Peter, Alsudani, Habeeb, Chang, Kenneth, Vakoc, Christopher R, Schatz, Michael C, McCombie, W Richard, Stillman, Bruce
Publicado 2021

RIOK1 kinase activity is required for cell survival irrespective of MTAP status

por Hörmann, Alexandra, Hopfgartner, Barbara, Köcher, Thomas, Corcokovic, Maja, Krammer, Teresa, Reiser, Christoph, Bader, Gerd, Shi, Junwei, Ehrenhöfer, Katharina, Wöhrle, Simon, Schweifer, Norbert, Vakoc, Christopher R., Kraut, Norbert, Pearson, Mark, Petronczki, Mark, Neumüller, Ralph A.
Publicado 2018

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

por Takao, Sumiko, Forbes, Lauren, Uni, Masahiro, Cheng, Shuyuan, Pineda, Jose Mario Bello, Tarumoto, Yusuke, Cifani, Paolo, Minuesa, Gerard, Chen, Celine, Kharas, Michael G, Bradley, Robert K, Vakoc, Christopher R, Koche, Richard P, Kentsis, Alex
Publicado 2021

Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition

por Hohmann, Anja F., Martin, Laetitia J., Minder, Jessica, Roe, Jae-Seok, Shi, Junwei, Steurer, Steffen, Bader, Gerd, McConnell, Darryl, Pearson, Mark, Gerstberger, Thomas, Gottschamel, Teresa, Thompson, Diane, Suzuki, Yutaka, Koegl, Manfred, Vakoc, Christopher R.
Publicado 2016

Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage

por Gryder, Berkley E., Wachtel, Marco, Chang, Kenneth, El Demerdash, Osama, Aboreden, Nicholas G., Mohammed, Wardah, Ewert, Winston, Pomella, Silvia, Rota, Rossella, Wei, Jun S., Song, Young, Stanton, Benjamin Z., Schäfer, Beat, Vakoc, Christopher R., Khan, Javed
Publicado 2020